DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blm and Wrn

DIOPT Version :9

Sequence 1:	NP_524319.2	Gene:	Blm / 41366	FlyBaseID:	FBgn0002906	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	XP_006253318.1	Gene:	Wrn / 290805	RGDID:	1564788	Length:	1400	Species:	Rattus norvegicus

Alignment Length:	1079	Identity:	301/1079 - (27%)
Similarity:	465/1079 - (43%)	Gaps:	212/1079 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 VMRQKFKARTQLVQ-NSLDKKESQLKAEQEALEKEEIEMQAEQAQQTVLSSSSPEKSRPIMPLPK 479
            ::.||.:.....|| .:|:|.|..|..|.    |:::...:|:.:.  |::..|...|.:..|.:
  Rat   216 IIYQKLENLGDAVQVFALNKAEESLPMEM----KKQLNSISEEMRD--LANHFPVTCRNLETLQR 274

  Fly   480 VQEIKDEKIPNRNQLIHDLCGEPD---NFSPP------SSPRDTQLIPKRQQLINDLCGEPDDFS 535
            |..|.:....|...|...:|...|   ...|.      ||.....:..|.:|:     ||...|
  Rat   275 VPMILENISENLCSLRKVICASTDTGTKLEPGGGSHLLSSEGSAAVGEKEKQM-----GEHRTF- 333

  Fly   536 PPSKQN--DPHLLRKCEELVHDLCEEPDDYLAQSMMLDGDLEEEQLNGPTQGTTTSGMDDDEDDL 598
            |..|:.  ||.|    :.||..  |..|.:..|.....|..|:|             |:|
  Rat   334 PKIKEEAWDPEL----DSLVKH--EAVDVFRKQVKQEKGGFEDE-------------MED----- 374

  Fly   599 EGLLAEIEDEHQKMQGRRSEFNGYSYKELEAVKVKEKHK----ETPINISLDDDG-----FPEYD 654
             .||.|:.:....|    ...:.|..::||....:|||.    :...::|.|||.     ..|.|
  Rat   375 -SLLREVMERTCLM----PSISEYDLQDLEQQAKEEKHNAISHQFSEHLSPDDDEKDSSYIIESD 434

  Fly   655 EAM-FEQMHSQAAANKSRVSSAGPSTSKSVVPTKQTSALHSQKLSGNFHANV---HNDGITGEFD 715
            |.: .|.:.|....|    |..|..|             ||:.|......|:   ..||     |
  Rat   435 EDLEMEMLKSLENLN----SDVGEPT-------------HSKWLETGGSVNLPPEEEDG-----D 477

  Fly   716 GQK-FEH------------STRLMHGLSYSFGLKSFRPNQLQVINATL-LGNDCFVLMPTGGGKS 766
            |:: ||.            :.:.::.|...||..||:|.|.:||::.| ...|..|:|.||.|||
  Rat   478 GKEAFEEEQEEEDHLLPEPNAKQINCLKTYFGHCSFKPVQWKVIHSVLEERRDNVVVMATGYGKS 542

  Fly   767 LCYQLPAILTEGVTIVISPLKSLIFDQINKLASLDICAKSLSGEQK---MADV-MAIYRDLESQP 827
            ||:|.|.:.|..:.||||||.||:.||:.:|...:|.|..|...|.   :.|: :..||
  Rat   543 LCFQYPPVYTGKIGIVISPLISLMEDQVLQLEMSNIPACLLGSAQPKNILGDIKLGRYR------ 601

  Fly   828 PMVKLLYVTPEKISSSARFQDTLDTLNSNNYISRFVIDEAHCVSQWGHDFRPDYKKLGVLKKRFP 892
                ::|:|||..|.:.   |.|..|:||..|:...:|||||:|:||||||..::.||.||...|
  Rat   602 ----IIYITPEFCSGNL---DLLQQLDSNIGITLIAVDEAHCISEWGHDFRSSFRTLGSLKTALP 659

  Fly   893 NVPTIALTATATPRVRLDILAQLNLKNCKWFLSSFNRSNLRYRVLPKKGVSTLDDISRYI---RS 954
            .||.|||:|||:..:|.||:..||||:.....:.|:|.||...|..|.| :.|.|:..::   .|
  Rat   660 LVPVIALSATASSSIREDIIRCLNLKDPHITCTGFDRPNLYLEVERKTG-NILQDLKPFLVRKTS 723

  Fly   955 KPQHFSG--IIYCLSRKECDETSKKMCKDGVRAVSYHAGLTDTDRESRQKDWLTGKMRVICATVA 1017
            ....|.|  ||||.|||..::.:.::.|..|...:||||:..::|:.....:|..:::.:.||:|
  Rat   724 SAWEFEGPTIIYCPSRKVTEQVTVELGKLNVACQAYHAGMKISERKDIHHRFLRDEIQCVVATIA 788

  Fly  1018 FGMGIDKPDVRFVLHYSLPKSIEGYYQEAGRAGRDGDVADCILYYNYSDMLRIKKMLDSDKALQY 1082
            |||||:|.|:|.|:||..||.:|.||||.|||||||..:.|.|.:..:|....:..|     ::.
  Rat   789 FGMGINKADIRKVIHYGAPKEMESYYQEIGRAGRDGLQSSCHLLWAPADFNTTRNRL-----IEI 848

  Fly  1083 NVKKIHVDNLYRIVGYCENL--TDCRRAQQLDYFGEHFTSEQCLE--NRETACDNCINKRAYKAV 1143
            :.:|..:..|..:|...:.|  :.|||...|.:|.:....:..|.  ..|..||||..:
  Rat   849 HNEKFRLHKLKMMVKMEKYLHSSRCRRQIILSHFEDKRLQKASLAVMGTEKCCDNCRPR------ 907

  Fly  1144 DALEH---ARKAARAVKDLCSGRSRFTLLHIADV-------------LKGSKIKKIID-FNHHKT 1191
              |.|   |..:....:|.  |...|.||...|:             |:||..:::.: :::|:.
  Rat   908 --LNHCSSANNSEDTAQDF--GPQAFQLLSAVDILQEKFGIKIPILFLRGSNSQRLPEKYHNHRL 968

  Fly  1192 PHHGVLKD----WDKNDVHRLLRKMVIDGFLREDLIFTNDF-------PQAYLYLGNNISKLMEG 1245
              .|..|:    |.|...|.|    :.:|||.| :...|.|       .:...:||..|   ::.
  Rat   969 --FGAGKEQAESWWKALSHHL----IAEGFLVE-VPKQNKFIKTCSLTKKGRKWLGEAI---LQS 1023

  Fly  1246 TPNFEFAVTKNAKEAKAAVGSVSDGATSST--------ADGQSGMREIHERCYTDLLDLCRTIAS 1302
            .|:......:.|...||.:.| |:..:|.|        ..|.|..:...|..|:|.:.  ...:|
  Rat  1024 PPSLVLQADEEAFSRKALLSS-SNPVSSETKPHSSNQKPTGSSTQQSNLEGAYSDKVP--EKFSS 1085

  Fly  1303 QRNVTMASIMNIQALKSMAETLPI---TEKDMCSIPHVTKANFDKYGAKLLEITSNYASEKLLMQ 1364
            ..|:...|::......|.:...|:   .|.|..::.:          |:|:|....:|:|..:..
  Rat  1086 GSNIPKKSVVMQSPGTSYSSWEPVISAQEVDTRTVLY----------ARLVEARQKHANEVDVPP 1140

  Fly  1365 AVLDEEEEQA-AAKQRPSTSGWNNESVDWDMAVASQGNA 1402
            |||...:... .||.||:|.. |.:.:|.    .|:|.|
  Rat  1141 AVLATNKVLLDMAKMRPTTVE-NVKQIDG----VSEGKA 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blm	NP_524319.2	RQC	1140..1253	CDD:286470	29/140 (21%)
		HRDC	1286..1352	CDD:278967	12/68 (18%)
		RecQ	729..1359	CDD:223588	210/682 (31%)
		DEAD	739..908	CDD:278688	72/173 (42%)
		HELICc	931..1061	CDD:238034	54/134 (40%)
		RecQ_Zn_bind	1066..1134	CDD:292742	15/71 (21%)
Wrn	XP_006253318.1	RNaseD_like	55..223	CDD:176650	2/6 (33%)
		recQ_fam	502..975	CDD:129701	173/503 (34%)
		DEAD	515..676	CDD:278688	72/173 (42%)
		HELICc	<730..832	CDD:238034	45/101 (45%)
		RecQ_Zn_bind	837..904	CDD:292742	15/71 (21%)
		RQC	923..1016	CDD:214936	22/101 (22%)
		HRDC	1118..1194	CDD:128635	18/72 (25%)
		HTH_40	1226..1316	CDD:291179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820