DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blm and Recql5

DIOPT Version :9

Sequence 1:	NP_524319.2	Gene:	Blm / 41366	FlyBaseID:	FBgn0002906	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_001099323.1	Gene:	Recql5 / 287834	RGDID:	1310823	Length:	973	Species:	Rattus norvegicus

Alignment Length:	836	Identity:	267/836 - (31%)
Similarity:	396/836 - (47%)	Gaps:	172/836 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   719 FEHSTRLMHGLSYSFGLKSFR-PNQLQVINATLLGN-DCFVLMPTGGGKSLCYQLPAILTEGVTI 781
            |:...|:...|...||..||: |.|...|.|.:.|: |.||.||||.||||||||||:|.:|:||
  Rat    10 FDRERRVRSTLKKVFGFDSFKTPLQESAIMAVVKGDKDVFVCMPTGAGKSLCYQLPAVLAKGITI 74

  Fly   782 VISPLKSLIFDQINKLASLDICAKSLSGEQKMADVMAIYRDLESQPPMVKLLYVTPEKISSSARF 846
            |:|||.:||.||::.|.:|.:...||:.:..:.:...:..|||...|..||||:||| :::||.|
  Rat    75 VVSPLIALIQDQVDHLLALKVQVSSLNSKLSVQERKELLSDLERDKPRTKLLYITPE-MAASASF 138

  Fly   847 QDTLDTLNSNNYISRFVIDEAHCVSQWGHDFRPDYKKLGVLKKRFPNVPTIALTATATPRVRLDI 911
            |.||::|.|.|.:|..|:|||||||||||||||||.:||.|:.|..:.|.:||||||||:|:.|:
  Rat   139 QPTLNSLLSRNLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLAHAPCVALTATATPQVQEDV 203

  Fly   912 LAQLNLKNCKWFLSSFN----RSNLRYRV-----LPKKGVSTLDDISRYIRSKPQHFS----GII 963
            .|.|:||..   ::||.    |:||.|.|     :|....:..|...:.:..|..:.|    ||:
  Rat   204 FAALHLKQP---VASFKTPCFRANLFYDVQFKELIPDVYGNLRDFCLKALGQKADNGSSSGCGIV 265

  Fly   964 YCLSRKECDETSKKMCKDGVRAVSYHAGLTDTDRESRQKDWLTGKMRVICATVAFGMGIDKPDVR 1028
            ||.:|:.|::.:.::...||.|.:|||||..::|...|.:|:..|:.||.||::||||:||.:||
  Rat   266 YCRTREACEQLAIELSSRGVNAKAYHAGLKASERTQVQNEWMEEKVPVIVATISFGMGVDKANVR 330

  Fly  1029 FVLHYSLPKSIEGYYQEAGRAGRDGDVADCILYYNYSD----MLRIKKML----------DSDKA 1079
            ||.|:::.||:.|||||:|||||||..:.|.|||:.:|    ...|:|.|          .||||
  Rat   331 FVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIRKELAKLQEKRGNKPSDKA 395

  Fly  1080 --LQYNVKKIHVDNLYRIVGYCENLTDCRRAQQLDYFGEHFTSEQCLENRETACDNCINKRAY-K 1141
              |.::.          :|.:||.: .||.|....|||:  ....|.:    .||.|.:..|. |
  Rat   396 TLLAFDA----------LVTFCEEV-GCRHAAIAKYFGD--APPACAK----GCDCCQSPAAIRK 443

  Fly  1142 AVDALEHARKAARAVKDLCSGRSR---FTLLHIADVLKGSKIKKIIDFNHHKTPHHGVLKDWDKN 1203
            .:|||||:....:.    |.|.|:   |.    .::.:|.: :....|:.:.....| ..|..::
  Rat   444 KLDALEHSSSWGKT----CIGPSQGDGFD----PELYEGGR-RGYGGFSRYDEGSGG-SGDEGRD 498

  Fly  1204 DVHRLLRKMVIDGFLREDLIFTNDFPQAYLYLGNNISKLMEGTPNFEFAVTKNAKEAK------- 1261
            :.|:           ||..:|..  .|..|..|.. :|..|.||..|....::|...|
  Rat   499 EAHK-----------REWNLFYQ--RQMSLRKGKE-AKPEEFTPPGEDCPLRDASSRKIPKLTVK 549

  Fly  1262 ----------AAVGSVSDGATSS-TADGQSGMREIHERCYTDLLDLCRTIASQRNVTMASIM--- 1312
                      .|:.|....|.|: .||.|:...|:....:..        |...|:..||::
  Rat   550 AREHCLRLLEEALNSNHQAAGSTHGADLQAKAVELEHETFRS--------AKMVNLYKASVLKKV 606

  Fly  1313 -----------------NIQALKSMAETLPITEKDMCSIPHVTKANFDKYGA----------KLL 1350
                             :.::..::||.|..::.|:....|:......:.||          ...
  Rat   607 AEIHKASKDGQLYDMESSTKSCGAIAELLEPSDYDIPPTSHLYSLKPKRVGAGFSKGPCPFQTAT 671

  Fly  1351 EITSNYASEKLLMQAVLDEEEEQAAAKQRPSTSGWNNESVDWDM----------AVASQGNA--- 1402
            |:.....:|||..:|.|:.|:|         .|||..:..|.|.          |..|:.|.
  Rat   672 ELLGKSQTEKLAPEAALESEQE---------PSGWVCDPQDGDRSKPCLGYQEEAPGSRTNCGDP 727

  Fly  1403 ----NTSGAS-GFNSFRAGKRKKIYKSGASK---------RYKTSTTSPAARKTTS 1444
                .|.|:| |....||.||:::..:.|.|         |.:|....|||...:|
  Rat   728 SPEKRTKGSSQGSAKARASKRQQLLATAARKDSQSITRFLRQRTECPPPAASVPSS 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blm	NP_524319.2	RQC	1140..1253	CDD:286470	26/116 (22%)
		HRDC	1286..1352	CDD:278967	11/95 (12%)
		RecQ	729..1359	CDD:223588	234/712 (33%)
		DEAD	739..908	CDD:278688	90/170 (53%)
		HELICc	931..1061	CDD:238034	56/138 (41%)
		RecQ_Zn_bind	1066..1134	CDD:292742	21/83 (25%)
Recql5	NP_001099323.1	DEXDc	22..229	CDD:214692	106/210 (50%)
		DEAD	31..201	CDD:278688	91/170 (54%)
		DEAH box	157..160		2/2 (100%)
		HELICc	258..363	CDD:238034	49/104 (47%)
		RecQ_Zn_bind	368..435	CDD:292742	21/83 (25%)
		Interaction with POLR2A. /evidence=ECO:0000250	491..621		28/152 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..538		6/20 (30%)
		RecQ5	626..816	CDD:284397	39/167 (23%)
		Interaction with RAD51. /evidence=ECO:0000250	653..726		18/81 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	679..795		31/114 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..884
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820