DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blm and wrn-1

DIOPT Version :9

Sequence 1:	NP_524319.2	Gene:	Blm / 41366	FlyBaseID:	FBgn0002906	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_495324.2	Gene:	wrn-1 / 174081	WormBaseID:	WBGene00006944	Length:	1056	Species:	Caenorhabditis elegans

Alignment Length:	1045	Identity:	279/1045 - (26%)
Similarity:	444/1045 - (42%)	Gaps:	198/1045 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   485 DEKIPNRNQLIHDLCGEPDNFSPPSSPRDTQLIPKRQQLINDLCGEPDDFSPPSKQNDPHLLRKC 549
            |:.:|:...      |..:...|.:.|.|...:|:.:.       |.|...|....|      |.
Worm     5 DDDLPSTRP------GSVNEELPETEPEDNDELPETEP-------ESDSDKPTVTSN------KT 50

  Fly   550 EELVHDL-CEEPDDYLAQSMMLDGDL--EEEQLNGPTQGTTTSGMDDDE--DDLEGLLAEIEDEH 609
            |..|.|. .:..||::.........:  :.::....|..:.:|..||.:  ||.|.:.|  .||.
Worm    51 ENQVADEDYDSFDDFVPSQTHTASKIPVKNKRAKKCTVESDSSSSDDSDQGDDCEFIPA--CDET 113

  Fly   610 QKMQGRRSEFNGYSYKELEAVKVKEKHKETPINISLDDDGFPEYDEAMFEQMHSQAAANKSRVSS 674
            |::...:   .||:.:...:||.|           .||    .:|:.:.|:..|:.:.:....|.
Worm   114 QEVPKIK---RGYTLRTRASVKNK-----------CDD----SWDDGIDEEDVSKRSEDTLNDSF 160

  Fly   675 AGPSTSKSVVPTKQTSALHSQKL-SGNFHANVHNDGITGEFDGQKFEHST----RLMHGLSYSFG 734
            ..|....||:..:.|.....|.| .|.|..: .|.....|....|:...|    ..::.|:..||
Worm   161 VDPEFMDSVLDNQLTIKGKKQFLDDGEFFTD-RNVPQIDEATKMKWASMTSPPQEALNALNEFFG 224

  Fly   735 LKSFRPNQLQVINATLLGNDCFVLMPTGGGKSLCYQLPAILTEGVTIVISPLKSLIFDQINKLAS 799
            .|.||..|..|:...|.|.|.||||.||.|||:|||||::|...:|:|:|||.||:.||:..|.|
Worm   225 HKGFREKQWDVVRNVLGGKDQFVLMSTGYGKSVCYQLPSLLLNSMTVVVSPLISLMNDQVTTLVS 289

  Fly   800 LDICAKSLSGEQKMADVMAIYRDLESQPPMVKLLYVTPEKISSSARFQDTLDTLNS-NNYISRFV 863
            ..|.|..|.|.....:    :..:.:....::.:|::||.::|    |..|:.|.| ..:||...
Worm   290 KGIDAVKLDGHSTQIE----WDQVANNMHRIRFIYMSPEMVTS----QKGLELLTSCRKHISLLA 346

  Fly   864 IDEAHCVSQWGHDFRPDYKKLGVLKKR--FPNVPTIALTATATPRVRLDILAQLNLKNCKWFLSS 926
            |||||||||||||||..|:.|..::.|  ..|:|.||||||||.|||.|::|.|.|:......:|
Worm   347 IDEAHCVSQWGHDFRNSYRHLAEIRNRSDLCNIPMIALTATATVRVRDDVIANLRLRKPLITTTS 411

  Fly   927 FNRSNLRYRVLPKKGVSTLDDISRYIRS---KPQHFSG--IIYCLSRKECDETSKKMCKDGVRAV 986
            |:|.||...|...|.::  :|:..::::   |.:||.|  ||||.:::..|:.:..:.:.|||:.
Worm   412 FDRKNLYISVHSSKDMA--EDLGLFMKTDEVKGRHFGGPTIIYCQTKQMVDDVNCVLRRIGVRSA 474

  Fly   987 SYHAGLTDTDRESRQKDWLTGKMRVICATVAFGMGIDKPDVRFVLHYSLPKSIEGYYQEAGRAGR 1051
            .||||||...||....|::..|:..|.|||||||||||||||.|:||..|.:||.||||.|||||
Worm   475 HYHAGLTKNQREKAHTDFMRDKITTIVATVAFGMGIDKPDVRNVIHYGCPNNIESYYQEIGRAGR 539

  Fly  1052 DGDVADCILYYNYSDMLRIK-KMLDSDKALQYNVKKIHVDNLYRIVGYCE---NLTDCRRAQQLD 1112
            ||..:.|.:::...|:..|| |:.:|.:      |:..|:||..::...|   ....|||.|.|.
Worm   540 DGSPSICRVFWAPKDLNTIKFKLRNSQQ------KEEVVENLTMMLRQLELVLTTVGCRRYQLLK 598

  Fly  1113 YFGEHFTSEQCLENRETACDNCI------NKRAYKAVDALEHARKAARAVKDLCSGRSRFTLLHI 1171
            :|...:.....::  ...||.|.      ...:...||....::...:.:.::.:|::  .:...
Worm   599 HFDPSYAKPPTMQ--ADCCDRCTEMLNGNQDSSSSIVDVTTESKWLFQVINEMYNGKT--GIGKP 659

  Fly  1172 ADVLKGS-----KIK-----KIIDFNHHKTPHHGVLKDWDKNDVHRLLRKMVIDGFLRE------ 1220
            .:.|:||     :||     |:.....|      :...|.|    .|...:.|.|:|.|
Worm   660 IEFLRGSSKEDWRIKTTSQQKLFGIGKH------IPDKWWK----ALAASLRIAGYLGEVRLMQM 714

  Fly  1221 ---DLIFTNDFPQAYLYLGNNISKLMEGTPNFEFAVTKNAKEAKAAVGSVSDGATSSTADGQS-- 1280
               ..|..::..:.:|..|..:.  ::.||     :....|:.|||..:| .||:.|.:...|
Worm   715 KFGSCITLSELGERWLLTGKEMK--IDATP-----ILLQGKKEKAAPSTV-PGASRSQSTKSSTE 771

  Fly  1281 --------------------------------GMREIHERCYTDLLDLCRTIASQRNVTMASIMN 1313
                                            |:.|..::..:.|.|:...||:...|....|::
Worm   772 IPTKILGANKIREYEPANENEQLMNLKKQEVTGLPEKIDQLRSRLDDIRVGIANMHEVAPFQIVS 836

  Fly  1314 IQALKSMAETLPITEKDMCSIPHVTKANFDKYGAKLLEITSNYASEKLLMQAVLDEEEEQAAAKQ 1378
            ...|...|...|.:..::..|..::.....:||.:.::....::.|
Worm   837 NTVLDCFANLRPTSASNLEMIDGMSAQQKSRYGKRFVDCVVQFSKE------------------- 882

  Fly  1379 RPSTSGWNNESVDWDMAVASQGNANTSGASGFNSFRAGKRKKIYKSGASKRYKTSTTS-PAARKT 1442
                           ..:|:..|||........|    |.:|:......:.|.....| ..|::.
Worm   883 ---------------TGIATNVNANDMIPPELIS----KMQKVLSDAVRRVYTEHLISRSTAKEV 928

  Fly  1443 TSARG 1447
            .:|||
Worm   929 ATARG 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blm	NP_524319.2	RQC	1140..1253	CDD:286470	22/131 (17%)
		HRDC	1286..1352	CDD:278967	12/65 (18%)
		RecQ	729..1359	CDD:223588	214/700 (31%)
		DEAD	739..908	CDD:278688	75/171 (44%)
		HELICc	931..1061	CDD:238034	61/134 (46%)
		RecQ_Zn_bind	1066..1134	CDD:292742	18/71 (25%)
wrn-1	NP_495324.2	RecQ	213..882	CDD:223588	214/706 (30%)
		DEAD	232..394	CDD:278688	75/169 (44%)
		HELICc	441..549	CDD:238034	56/107 (52%)
		RecQ_Zn_bind	554..618	CDD:292742	18/71 (25%)
		RQC	632..730	CDD:286470	18/109 (17%)
		HRDC	806..886	CDD:128635	14/113 (12%)
		HTH_40	924..1002	CDD:291179	4/10 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445763at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820