Protein Alignment Blm and Recql5

DIOPT Version :10

• Sequence 1: NP_524319.2
• Gene: Blm / 41366
• FlyBaseID: FBgn0002906
• Length: 1487
• Species: Drosophila melanogaster
• Sequence 2: XP_006532421.1
• Gene: Recql5 / 170472
• MGIID: 2156841
• Length: 983
• Species: Mus musculus
• Alignment Length: 862
• Identity: 270/862 - (31%)
• Similarity: 393/862 - (45%)
• Gaps: 171/862 - (19%)

  Fly   719 FEHSTRLMHGLSYSFGLKSFR-PNQLQVINATLLG-NDCFVLMPTGGGKSLCYQLPAILTEGVTI 781
            |:...|:...|...||..||: |.|.....|.:.| .|.||.||||.||||||||||:|..|:||
Mouse    11 FDRERRVRSTLKKVFGFDSFKTPLQESATMAVVKGAEDVFVCMPTGAGKSLCYQLPALLASGITI 75

  Fly   782 VISPLKSLIFDQINKLASLDICAKSLSGEQKMADVMAIYRDLESQPPMVKLLYVTPEKISSSARF 846
            |:|||.:||.||::.|.:|.:...||:.:..:.:...:..|||...|..||||:||| :::||.|
Mouse    76 VVSPLIALIQDQVDHLLALKVQVSSLNSKLSVQERKELLSDLERDKPRTKLLYITPE-MAASASF 139

  Fly   847 QDTLDTLNSNNYISRFVIDEAHCVSQWGHDFRPDYKKLGVLKKRFPNVPTIALTATATPRVRLDI 911
            |.||::|.|.|.:|..|:|||||||||||||||||.:||.|:.|..:.|.:||||||||:|:.|:
Mouse   140 QPTLNSLVSRNLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLAHAPCVALTATATPQVQEDV 204

  Fly   912 LAQLNLKNCKWFLSSFN----RSNLRYRV-----LPKKGVSTLDDISRYIRSKPQHFS----GII 963
            .|.|:||..   ::||.    |:||.|.|     :|....:..|...:.:..|.::.|    ||:
Mouse   205 FAALHLKQP---VASFKTPCFRANLFYDVQFKELIPDVYGNLRDFCLKALGQKAENGSSSGCGIV 266

  Fly   964 YCLSRKECDETSKKMCKDGVRAVSYHAGLTDTDRESRQKDWLTGKMRVICATVAFGMGIDKPDVR 1028
            ||.:|:.|::.:.::...||.|.:|||||..:||...|.:|:..|:.||.||::||||:||.:||
Mouse   267 YCRTREACEQLAIELSSRGVNAKAYHAGLKASDRTQVQNEWMEEKVPVIVATISFGMGVDKANVR 331

  Fly  1029 FVLHYSLPKSIEGYYQEAGRAGRDGDVADCILYYNYSD----MLRIKKML----------DSDKA 1079
            ||.|:::.||:.|||||:|||||||..:.|.|||:.:|    ...|:|.|          .||||
Mouse   332 FVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIRKELAKLQEKRGNKPSDKA 396

  Fly  1080 --LQYNVKKIHVDNLYRIVGYCENLTDCRRAQQLDYFGEHFTSEQCLENRETACDNCINKRAY-K 1141
              |.::.          :|.:||.: .||.|....|||:  ....|.:    .||.|.|..|. |
Mouse   397 TLLAFDA----------LVTFCEEV-GCRHAAIAKYFGD--APPACAK----GCDYCQNPAAITK 444

  Fly  1142 AVDALEHARKAARAVKDLCSGRSR---FTLLHIADVLKGSKIKKIIDFNHHKTPHHGVLKDWDKN 1203
            .:||||.:...::.    |.|.|:   |.    .::.:|.: :....|:.:.....| ..|..::
Mouse   445 KLDALERSSSWSKT----CIGPSQGNGFD----PELYEGGR-RGYGGFSRYDEGSGG-SGDEGRD 499

  Fly  1204 DVHRLLRKMVIDGFLREDLIFTNDFPQAYLYLGNNISKLMEGTPNFEFAVTKNAKEAK------- 1261
            :.|:           ||..:|..  .|..|..|.. .|:.|.||..|....:.|...|
Mouse   500 EAHK-----------REWNLFYQ--KQMSLRKGKE-PKIEEFTPPDEDCPLREASSRKIPKLTVK 550

  Fly  1262 -----------AAVGSVSDGATSSTADGQSGMREIHERCYTDLLDLCRTIASQRNVTMASIMNIQ 1315
                       |.:.:.....::..||.|:...|:....:             ||..|.::....
Mouse   551 AREHCLRLLEEALISNHQAAGSTHGADLQAKAVELEHETF-------------RNAKMVNLYKAS 602

  Fly  1316 ALKSMAE----------------------TLPITEKDMCSIP---HVTKANFDKYGA-------- 1347
            .||.:||                      ....:|.....||   ||......:.||
Mouse   603 VLKKVAEIHKASKDGQLYDMESGTKSCGAAAEFSEPSDYDIPPTSHVYSLKPKRVGAGFSKGPCS 667

  Fly  1348 --KLLEITSNYASEKLLMQAVLDEEEEQAAAKQRPSTSGWNNESVDWDMAVASQGNANTSGASGF 1410
              ...|:.....|:|...:|:|:..:|         ..||..:..|.|.:....|....:..|..
Mouse   668 FQTATELLGKSHSQKQAPEAMLEGGQE---------PPGWVCDLQDEDRSKPHPGYQEKALGSSV 723

  Fly  1411 NSFRAGKRKKI-------YKSGASKRYKTSTTSPAARKTTSARGRGGRAGAKRAESSASSASGWK 1468
            |.......||.       .|:.|||:.:...|  ||||.:.   ...|...:|.||....||..:
Mouse   724 NCGDPSPEKKTKGSSQGSAKARASKKQQLLAT--AARKDSQ---NITRFLCQRTESPPLPASVPR 783

  Fly  1469 SKKTGNSFGFDLMPLPG 1485
            |:....|.|    .:||
Mouse   784 SEDASPSCG----DVPG 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Blm	NP_524319.2	RecQ	733..1217	CDD:440280	200/518 (39%)
		HRDC	1283..1357	CDD:470625	16/108 (15%)
Recql5	XP_006532421.1	RecQ	13..450	CDD:440280	191/457 (42%)
		RecQ5	627..818	CDD:399738	42/188 (22%)