Protein Alignment Blm and RecQ4

DIOPT Version :10

• Sequence 1: NP_524319.2
• Gene: Blm / 41366
• FlyBaseID: FBgn0002906
• Length: 1487
• Species: Drosophila melanogaster
• Sequence 2: XP_061519287.1
• Gene: RecQ4 / 1276585
• VectorBaseID: AGAMI1_001615
• Length: 1669
• Species: Anopheles gambiae
• Alignment Length: 1554
• Identity: 345/1554 - (22%)
• Similarity: 550/1554 - (35%)
• Gaps: 477/1554 - (30%)

  Fly    22 GNSQSQPKSRAASVRSKPPAVYNPIFLDASSSDDETTEISSQSNNGTIATKKSSRDPRTAKLKKH 86
            |.:...|::.||:.|.   .|.|..:..|..||.:....:|:..:   |||.|......|| |:.
Mosquito   322 GTAVVSPQATAAAARI---GVQNTAYDAAIHSDSDGVVENSEDES---ATKTSPGMLHIAK-KRK 379

  Fly    87 TYLDLSVSPLAKLSAKKYARDSPKKPTSLDLSVSPLAELLAKKSDRDSPKKPVQN-ENSYTYRGL 150
            .:..::.||:.::.||:      .||:....:|.|:.   :|..:...|:...:. |...|.:|.
Mosquito   380 IFTSINRSPVERVEAKQ------PKPSIETNNVLPVE---SKDVENQDPRGVAEEAEQGATPKGA 435

  Fly   151 SESPVENK-SIGDTLRKPPQKERKTSIVWLSDSPEKKVTQ-NERKIL---DSPL---------QR 201
            .:..|:.: |....:.|...::.||.:|     |..:.:: |.||:.   :.||         ..
Mosquito   436 PKKRVQKRVSKAKQVAKKMVEKAKTVVV-----PRARSSRTNARKVATYKEVPLADGVQDEMEHE 495

  Fly   202 FSFEDFPN----KENGNRHHLLTLP--------DSPPPPQPVKKPEKTMWQNETKTIQDKDSPA- 253
            ||.:|...    ||...|.....||        |....|:|...|.|.:.:..:.|...:..|.
Mosquito   496 FSADDEDKDPDYKEQLERESRGLLPADGDDPESDQEEEPKPKSAPAKRVSRARSATGVPRKQPTK 560

  Fly   254 --------NPLVSNNLASISTLLDSSRAPNTYKGSSRNLFEDSPEKSGSGE----QGY--KLGSA 304
                    :..||..|:..|:...|.|.....|.:.|.:..|..|:....|    |.|  :.|.|
Mosquito   561 VKRSTTRKSTTVSPKLSPGSSKPTSQRGRKAKKITKRKMDVDGEEEEAIPEAEQPQEYVPEFGLA 625

  Fly   305 KENEIP----------TKPATASLERNSVTSSPSPAAPLKPRYSVAFDNSLADYLKDLAQ---ND 356
            :...||          ||.|.:.:...:.:::..|::..|.|.:||.........|.:|.   |:
Mosquito   626 RLKSIPRLDINELVRDTKLADSFILGVAGSAAEGPSSNGKTRTTVAGSTKETALRKKMAAGKLNE 690

  Fly   357 NF-SIDPNKQNTETLKSTLGFFRNTYVELMEKYCSLIDQIPAMHFNEIAGFQPNTFLKLKVMRQK 420
            || .||..|:.....|.|:.:.|....:...|..:.:.. |.|......|.....|.........
Mosquito   691 NFVRIDIRKKVFVKGKKTINYSRYKKSQWKAKKAAALTG-PEMDMRGCDGGTLTCFQCGGTGHMA 754

  Fly   421 FKARTQLVQNSLDKKESQLKAEQEALEK------EEIEMQAEQAQQTVLSSSSPEKSRPIM-PLP 478
            |:.:..|       ::..|..:.:.:|:      ||.|..| .::...:.|:..|:..|:. |:.
Mosquito   755 FQCKKPL-------EDKLLPYDADTIEESSFPTLEEAEAMA-NSRTLAVHSNRIERLPPVANPVW 811

  Fly   479 KVQEIKDEKIPNRNQLIHDLCGEPDNFSPPSSPRDTQLIPKRQQLINDLCGEPDDFSPPSKQNDP 543
            |.||  .|.:|...|:     |||....|.:.|
Mosquito   812 KEQE--QEDLPAEEQV-----GEPGKEEPSTLP-------------------------------- 837

  Fly   544 HLLRKCEELVHDLCEEPDDYLAQSMMLDGDLEEEQLNGPTQGTTTSGMDDDEDDLEGLLAEIEDE 608
                                                              .||||:..:.:..||
Mosquito   838 --------------------------------------------------VEDDLDEPMEQESDE 852

  Fly   609 HQKMQGRRSEFNGYSYKELEAVKVKEKHKETPINISLDDDGFPEYDEAMFEQMHSQAAANKSRVS 673
            |                          |:||                   ||   .|||::
Mosquito   853 H--------------------------HQET-------------------EQ---SAAASQ---- 865

  Fly   674 SAGPSTSKSVVPTK--QTSALHSQKLSGNFHANV------HNDGITGEFDGQKFEHSTRLMHGLS 730
            .|.|:.....:|.:  :.|.|....:||.|...|      ..|........:.|| :.|:
Mosquito   866 PAAPAYIGHKIPEEFLKQSGLLEVTVSGGFKGTVEPLYQQRGDCTLPPTPPEVFE-ALRM----- 924

  Fly   731 YSFGLKSFRPNQLQVINATLLGNDCFVLMPTGGGKSLCYQLPAIL----TEGVTIVISPLKSLIF 791
              ||.:|||..|.:.:...|.|....|.:.||.||||||||||.|    ...:|:|||||.||:.
Mosquito   925 --FGHQSFRHGQERAVMRVLCGLSTLVTLSTGAGKSLCYQLPAYLYRKNRSCITLVISPLVSLME 987

  Fly   792 DQINKLASLDICAKSLSGEQ--KMADVMAIYRDLES-QPPMVKLLYVTPEKISSSARFQDTLDTL 853
            ||::.:... :.|..|...|  |:.|     |.::: ....|.:|.::||.:.|..:.......|
Mosquito   988 DQVHGMPDF-LNAHCLHTNQTPKVRD-----RTMQAIAAGEVDVLLISPEAVVSGEKSTGFGSLL 1046

  Fly   854 NSNNYISRFVIDEAHCVSQWGHDFRPDYKKL-GVLKKRFPNVPTIALTATATPRVRLDILAQLNL 917
            .....|:...||||||||||.|:|||.|..: .|||::......:.||||||.:.|..|::.|.:
Mosquito  1047 RQLPPIAFACIDEAHCVSQWSHNFRPSYLMICKVLKEKLGVKTILGLTATATVQTRQSIVSHLAI 1111

  Fly   918 KN-CKWFLSSF--------------NRSNLRYRVLPKKGVSTLDDISRYIRSKPQHFSGIIYCLS 967
            .: .:..:|..              ||......:|..:..|:|..|             |:||..
Mosquito  1112 PDGVQGIISDIPLPDNLLLTVSRDANRDVALVELLQSERFSSLQSI-------------IVYCTR 1163

  Fly   968 RKECDE--TSKKMC-KDGVRAVS----------------YHAGLTDTDRESRQKDWLTGKMRVIC 1013
            |.:|:.  |..:.| :|..||.:                ||||:..:.|.:.|..:::|::|::.
Mosquito  1164 RDDCERVATFIRTCFQDAARAAAAANAHKRKRLNYVAEPYHAGMPASRRRTIQNAFMSGELRIVV 1228

  Fly  1014 ATVAFGMGIDKPDVRFVLHYSLPKSIEGYYQEAGRAGRDGDVADC----------------ILYY 1062
            ||:||||||:|.|:|.::||::||:.|.|.||.|||||||.::.|                .:|.
Mosquito  1229 ATIAFGMGINKADIRAIIHYNMPKNFESYVQEVGRAGRDGLLSHCHLFLDGKGTDRNELRRFIYA 1293

  Fly  1063 NYSDMLRIKKML--------------DSDKALQYN-----VKKIHVDNLYRIVGYCENLTDC--- 1105
            |..|...|:|:|              :.|.||:..     |..|..|:.:..:...:..|..
Mosquito  1294 NSIDRHVIRKLLQKIFVPCACAKILTNKDLALELREELKAVNGIDWDDDFEELSTADGRTQADGG 1358

  Fly  1106 -------------------RRAQQLDYFGEHFTSEQC-LENRE-----------TACDNCINKRA 1139
                               ...||||...|:.|:..| ||..|           |.|    ...:
Mosquito  1359 GGGTRKRLCPGHEICFSIEATVQQLDIPEENITTFLCYLELDEQRYIQALSPAYTMC----KVMS 1419

  Fly  1140 YKAVDALEHARKAA------------RAVKDLCSGRSRFTLLHIADVLKGSKIKKIIDFNHHKTP 1192
            |..|..|..|.|..            |.:....|....|.::.:|..:
Mosquito  1420 YGGVRPLRQAAKECPPLAMAFALDLKRGISHATSTAIEFPVIDVASAI----------------- 1467

  Fly  1193 HHGVLKDWDKNDVHRLLRKMVIDGFLREDLIFTNDFPQAYLYLGNNISKLMEGTPNFE---FAVT 1254
                  .||...|...|:          :|.:|.         .||:.|....:..|.   |.|
Mosquito  1468 ------GWDSGVVKYQLK----------NLEWTT---------VNNVRKRSPLSVTFTELGFRV- 1506

  Fly  1255 KNAKEAKAAVGSVSDGATSSTADGQSGMREIHERCYTDLLDLCRTIASQRNVTMASIMNI-QALK 1318
                   .|.|.::|.......||      ::||           :..|....:|.:..| .||.
Mosquito  1507 -------RAPGDLTDEELDHALDG------LYER-----------VTHQERTQLAQLQYISDALN 1547

  Fly  1319 SMA-ETL-PITEKDMCSIPHVTKANFDKYGAKLLE-ITSNYASEKL-LMQAVLDEEEEQ 1373
            |:. .|: |::..|..:.|.      ||....:.| .|::.:.|:: ::....|..:||
Mosquito  1548 SVCFNTIGPVSRADCPTGPS------DKLKTIVREYFTTDISKEQIEIVPEPDDTTDEQ 1600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Blm	NP_524319.2	RecQ	733..1217	CDD:440280	162/606 (27%)
		HRDC	1283..1357	CDD:470625	16/77 (21%)
RecQ4	XP_061519287.1	None