Protein Alignment Blm and blm

DIOPT Version :10

• Sequence 1: NP_524319.2
• Gene: Blm / 41366
• FlyBaseID: FBgn0002906
• Length: 1487
• Species: Drosophila melanogaster
• Sequence 2: XP_012813863.2
• Gene: blm / 100124311
• XenbaseID: XB-GENE-982561
• Length: 1368
• Species: Xenopus tropicalis
• Alignment Length: 1590
• Identity: 483/1590 - (30%)
• Similarity: 723/1590 - (45%)
• Gaps: 359/1590 - (22%)

  Fly     9 RKQLTLSSFIGLDGN-SQSQPKSRAASVRSK--PPAVYNPIFLDASSS------------DDETT 58
            :|||.|.|..|.... |..:|||...:.:.|  |....:..|::...:            :|..|
 Frog    10 QKQLELFSAKGTANKLSLQKPKSSVFTFKKKCSPNGSLSTGFVEVKQNVALKDKNVNVKQNDVQT 74

  Fly    59 EI-----SSQSN--NG--TIATKKSSRDPRTAKLKKHTYLDLSVSPLAKLSAKKYAR--DSPKKP 112
            .:     |::.|  ||  |....||::.|:|..:|.|.:::        .||.|:.|  ||..|.
 Frog    75 NLTVLPKSAERNKINGFFTPVYTKSTQLPQTVAVKDHVHIN--------DSANKHPRVEDSASKK 131

  Fly   113 TSLDLSVSPLAELLAKKSDRDSPKKPVQNENSYTYRGLSESPVENKSIGDTLRKPPQKERKTSIV 177
            |.::.|...:.. |.:..|.|.             ...|.||  .||....::..||..:.||.|
 Frog   132 TGINTSFGSVTS-LEEWDDLDD-------------FDTSVSP--PKSQAGKIKITPQNCKNTSPV 180

  Fly   178 WLSDSPEKKVTQNERKILDSPLQRFSFEDFPNKENGNRHHLLTLPDSPPPPQPV--KKP-EKTMW 239
                              .|.:|..|                  |..|...:.:  ||| |....
 Frog   181 ------------------SSKIQCLS------------------PKGPTIEKQMCAKKPYENNEI 209

  Fly   240 QNETKTI---QDKDSPANPLVSNNLASIS-TLLDSSRAPNTYKGSSRNLFEDSPEKSGSGEQGY- 299
            .:|.:.:   |..:.|...||.  |.|:. |.|.|:.     |.:.||:     :.||:.:..:
 Frog   210 ASEPQKLVHAQTAEMPDKSLVC--LGSVEHTNLGSAE-----KDTCRNI-----DYSGTDDIEHD 262

  Fly   300 --KLGSAK-ENE-------IPTKPATASLERNSVTSSPSP----AAPLKPRYSVAFD----NSLA 346
              .|..|. |||       ||..|:..||      |||..    .|..|.:.|...|    .:.|
 Frog   263 QETLSQALIENEDDCEPDFIPPSPSDESL------SSPPVLRVIGAQRKHKVSSVTDVNDCENTA 321

  Fly   347 DYLKDLAQNDNFSIDPNKQNTETLKSTLGFFRNTYVELMEKYCSLIDQIPAMHFNEIA-GFQPNT 410
            |:|:  :|..:.|:|      ..:.|.|       :.:|.:.|.|:|:||....:.:: |..
 Frog   322 DHLQ--SQCVSSSLD------SKVPSHL-------LSVMLEICDLVDKIPISELHVLSCGMD--- 368

  Fly   411 FLKLKVMRQKFKARTQLVQNSLDKKESQLKAEQEALEKEEIEMQAEQAQQTVLSSSSPEKSRPIM 475
                  :::|...|.:|:.|:                             :||.||..:.|
 Frog   369 ------LKKKRDMRKRLLLNN-----------------------------SVLRSSPADSS---- 394

  Fly   476 PLPKVQEIKDEKIPNRNQLIHDLCGEPDNFSPPSSPRDTQ--------LIPKRQQLINDLCGEPD 532
                  .:.....|::|.       |.|    .|:|:|.:        .|.|..:|:.|..|
 Frog   395 ------TVSLTSCPSQNM-------EFD----VSAPKDAESFSGSSVNKIFKFNKLVADEFG--- 439

  Fly   533 DFSPPSKQNDPHLLRKCEELVHDLCEEPDDYLAQSMMLDGD-------------LEEEQLNGPTQ 584
                 :|.||     :..:...:..|:.::..:.|:...||             |...|.|.|..
 Frog   440 -----TKGND-----RASDFAPNFREKMENKTSFSLQAGGDSVMEDSFSFQSNVLSTSQFNTPQN 494

  Fly   585 GTTTSG----------MDD-DEDDLEGLLAEIEDEHQKMQGRRSEFNGYSYKELEAVKVKEKHKE 638
            ....|.          :|| |..||:                 .:.:.:..::.:     ::..:
 Frog   495 EKPVSSSTCARPISQPIDDMDNPDLD-----------------FDIDNFDIEDFD-----DQLMD 537

  Fly   639 TPINISLDDDGFPEYD---EAMFEQMHSQAAANKSRVS--SAGPSTSKSVVPTKQTSALHSQKLS 698
            :|....:.....|:|.   |..|:      :.:|.:|:  :.|..|:..:    ..|.|..|
 Frog   538 SPAAPPVSSKNAPQYPTICETQFD------SGSKEKVTRHNVGDKTNTEL----SDSLLKPQ--- 589

  Fly   699 GNFHANVHNDGITGEFDGQKFEHSTRLMHGLSYSFGLKSFRPNQLQVINATLLGNDCFVLMPTGG 763
                  :.|..:. .|....|.||..:|......|||..||.|||:.|||.|||.|||:||||||
 Frog   590 ------IVNPALE-RFKSFNFPHSKEMMKIFHKKFGLHRFRTNQLEAINACLLGEDCFILMPTGG 647

  Fly   764 GKSLCYQLPAILTEGVTIVISPLKSLIFDQINKLASLDICAKSLSGEQKMADVMAIYRDLESQPP 828
            |||||||||..::.|||||||||:|||.||:.||.||||.|..|:|::..|:..:||..|..:.|
 Frog   648 GKSLCYQLPGCVSPGVTIVISPLRSLIVDQVQKLTSLDIPATYLTGDKTDAEAASIYLQLSKKDP 712

  Fly   829 MVKLLYVTPEKISSSARFQDTLDTLNSNNYISRFVIDEAHCVSQWGHDFRPDYKKLGVLKKRFPN 893
            ::|||||||||:.:|.|...|::.|.....::||||||||||||||||||||||:|.:|:::|.:
 Frog   713 IIKLLYVTPEKVCASTRLISTMENLYERQLLARFVIDEAHCVSQWGHDFRPDYKRLNMLRQKFQS 777

  Fly   894 VPTIALTATATPRVRLDILAQLNLKNCKWFLSSFNRSNLRYRVLPKKGVSTLDDISRYIRSKPQH 958
            ||.:||||||.|||:.|||.||.:...:.|..||||.||:|.|||||......|...:|:....:
 Frog   778 VPMMALTATANPRVQKDILNQLKMTKPQIFTMSFNRDNLKYDVLPKKPKRVALDCVEWIKKYHPN 842

  Fly   959 FSGIIYCLSRKECDETSKKMCKDGVRAVSYHAGLTDTDRESRQKDWLT-GKMRVICATVAFGMGI 1022
            .|||||||||.|||..:..:.|.|:.|::|||||.|::|:..|..|:. ...:|||||:||||||
 Frog   843 DSGIIYCLSRHECDTMADTLQKGGLAALAYHAGLADSNRDYVQHKWINQDDCQVICATIAFGMGI 907

  Fly  1023 DKPDVRFVLHYSLPKSIEGYYQEAGRAGRDGDVADCILYYNYSDMLRIKKMLDSDKALQYNVKKI 1087
            ||||||:|:|.|||||:||||||:|||||||:::.|:|:|:|||:.||::::..:|....:.|:.
 Frog   908 DKPDVRYVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYSYSDVTRIRRLIQMEKDGNSHTKQT 972

  Fly  1088 HVDNLYRIVGYCENLTDCRRAQQLDYFGE-HFTSEQCLENRETACDNCINKRAYKAVDALEHARK 1151
            |.:|||.:|.||||:.:|||.|.|.|||| :|....|.||...:||||:.::.:|:.:..:..|.
 Frog   973 HFNNLYSMVHYCENVVECRRMQLLAYFGENNFNPNFCKENTRVSCDNCLGRKEFKSRNVTDDVRN 1037

  Fly  1152 AARAVKDLCS-----GR---SRFTLLHIADVLKGSKIKKIIDFNHHKTPHHGVLKDWDKNDVHRL 1208
            ..|.|::.||     ||   ||.||..:.|:..|||..||      :|...|....:.:::..||
 Frog  1038 IVRFVQENCSSARGKGRSNSSRLTLNMMVDIFLGSKSAKI------QTGLFGKGAAYSRHNAERL 1096

  Fly  1209 LRKMVIDGFLREDLIFT-NDFPQAYLYLGNNISKLMEGTPNFEFAVTKNAKEAKAAVGSVSDGAT 1272
            .||:|:|..|.|:|..| ||...||:..|.....::.|....||..|:||...:....||    .
 Frog  1097 FRKLVLDRILDEELYITANDQAVAYVKTGERAQAVLNGFLTVEFQDTENASSLRKQKASV----V 1157

  Fly  1273 SSTADGQSGMREIHERCYTDLLDLCRTIASQRNVTMASIMNIQALKSMAETLPITEKDMCSIPHV 1337
            ::|    |...|:.::|..:|.:||:.:.....|...:|.|...::.:||:|......:..|..|
 Frog  1158 ANT----SQREEMVKKCQAELTELCKRLGKIFGVHYFNIFNTATIRRIAESLSPEPDVLLQIDGV 1218

  Fly  1338 TKANFDKYGAKLLEITSNYASEKLLMQAVLDEEEEQAAAKQRPSTS-------GWNNESVDWDMA 1395
            |:...:||||:|:::...|:...|.::.:..:....|....|...|       |...|...:...
 Frog  1219 TEDKLEKYGAELIDVLQKYSEWTLPVEDIHQKSSGPANFSARRYDSDDDDDDDGERGEKSSYFST 1283

  Fly  1396 VASQG----NANTSGASGFNSFRAGKRKKIYKSGASKRYKTSTTSPAARKTTSARGRGGRAGAKR 1456
            .:::|    ||.|        ||..|::|....|.....|.:|.|.:...:|
 Frog  1284 KSNKGTKRKNAPT--------FRKSKKRKTGGDGQQSHPKNATGSFSRNNST------------- 1327

  Fly  1457 AESSASSASGWKSKKTG--NSFGFDLMPLP 1484
            |::|:|..||   .|||  ...||...|||
 Frog  1328 AKTSSSYYSG---SKTGADKRPGFMAPPLP 1354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Blm	NP_524319.2	RecQ	733..1217	CDD:440280	252/493 (51%)
		HRDC	1283..1357	CDD:470625	19/73 (26%)
blm	XP_012813863.2	BLM_N	1..336	CDD:465064	95/411 (23%)
		BDHCT	341..380	CDD:462356	10/54 (19%)
		recQ_fam	611..1094	CDD:129701	246/488 (50%)
		HRDC	1165..1243	CDD:128635	20/77 (26%)