DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mgr and VBP1

DIOPT Version :9

Sequence 1:	NP_650067.1	Gene:	mgr / 41365	FlyBaseID:	FBgn0264694	Length:	194	Species:	Drosophila melanogaster
Sequence 2:	NP_001290472.1	Gene:	VBP1 / 7411	HGNCID:	12662	Length:	233	Species:	Homo sapiens

Alignment Length:	197	Identity:	100/197 - (50%)
Similarity:	141/197 - (71%)	Gaps:	7/197 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTGIMDSVEMPKLP--ENQKTFAGIPEAVFLEEIDTFMSQPENENCEKVLQRLDEQHGKYRFMAC 63
            |..:.||....::.  ..::...|||||||:|::|:||.||.||..:.||::||||:.||:||..
Human    37 MAAVKDSCGKGEMATGNGRRLHLGIPEAVFVEDVDSFMKQPGNETADTVLKKLDEQYQKYKFMEL 101

  Fly    64 NLEARRRKLKSQIPDLERSLEMVNVLRKEDE---ERETQFLLSDQVFIKTLVPPTKTVYLWLGAS 125
            ||..::|:||.|||:::::||::..::|:.|   ..||:|||:|.::.|..||||..|.|||||:
Human   102 NLAQKKRRLKGQIPEIKQTLEILKYMQKKKESTNSMETRFLLADNLYCKASVPPTDKVCLWLGAN 166

  Fly   126 VMLEYPLDEAEALLNQNITSAVGNLKSVEHDQDFLRDQITTTEVNMARVYNWGVKKRQA--ATKT 188
            |||||.:|||:|||.:|:::|..||.|:|.|.||||||.|||||||||||||.||:|..  :||.
Human   167 VMLEYDIDEAQALLEKNLSTATKNLDSLEEDLDFLRDQFTTTEVNMARVYNWDVKRRNKDDSTKN 231

  Fly   189 TA 190
            .|
Human   232 KA 233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mgr	NP_650067.1	Prefoldin	58..175	CDD:281054	65/119 (55%)
VBP1	NP_001290472.1	Prefoldin	96..216	CDD:397237	65/119 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160164
Domainoid	1	1.000	144	1.000	Domainoid score	I4631
eggNOG	1	0.900	-	-		E1_KOG3313
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2531
Inparanoid	1	1.050	198	1.000	Inparanoid score	I3808
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53938
OrthoDB	1	1.010	-	-		D1567796at2759
OrthoFinder	1	1.000	-	-		FOG0005083
OrthoInspector	1	1.000	-	-		oto88303
orthoMCL	1	0.900	-	-		OOG6_102595
Panther	1	1.100	-	-	LDO	PTHR12409
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R906
SonicParanoid	1	1.000	-	-		X3603
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800