Protein Alignment pros and Prox2

DIOPT Version :10

• Sequence 1: NP_001247045.1
• Gene: pros / 41363
• FlyBaseID: FBgn0004595
• Length: 1835
• Species: Drosophila melanogaster
• Sequence 2: NP_780407.1
• Gene: Prox2 / 73422
• MGIID: 1920672
• Length: 593
• Species: Mus musculus
• Alignment Length: 754
• Identity: 206/754 - (27%)
• Similarity: 288/754 - (38%)
• Gaps: 257/754 - (34%)

  Fly  1167 LFSKQADSVTAAAEQLNKDLLLASQILDRKSPRTKVADRPQ--NGPTPATQSGNNGSLLLAN--- 1226
            |...|:.:.|..||:...|        ..:||.|..|.|..  :|..|::      ||..|:
Mouse     8 LLPPQSRTCTHLAEETCMD--------QERSPATAEAGRDSFPSGQLPSS------SLTEADWFW 58

  Fly  1227 ------SQMPSQTTASG------SSAQQQQQQNAQQQHQGSQQQQQQNVVQQQ------------ 1267
                  .:...:|...|      ||...:.:::.:...:|.:::::|::...|
Mouse    59 DEHIQAKRARVETIVRGMCLSPSSSVSGRARESLRCPEKGRERKRKQSLPMHQGPLKSSPAWERG 123

  Fly  1268 ------NVAQQQHMQQQQQQQQSHPLLPPNCQQLISAPRLNGSQLSFASPAAAAAAAMGLQMHHA 1326
                  .|.:|.|:.:||.:.                                      ||.|
Mouse   124 PKKGGTRVKEQLHLLKQQLRH--------------------------------------LQEH-- 148

  Fly  1327 AAAAAMSAQQQQQQSGDPGANTNPNSGP-ANPTNSSLS---TLNIPPPHIRPSPTAAAMFQAPKT 1387
                .:.|.:.:..:..|| .|.|.|.| |.|.||..|   |:...|..........|
Mouse   149 ----VLQATEPRAPAQSPG-GTEPRSSPRARPRNSCSSGAWTVENEPHQSSSKDLCGA------- 201

  Fly  1388 PQGMNPVAAAALYNSMTGPFCLPPDQQQQQQTAQQQQSAQQQQQSSQQTQQQLEQNEALSLVVTP 1452
               :.|.||..|..| ..|...|...:...:|.:::.|
Mouse   202 ---VKPGAAEVLQYS-EEPMLCPSGPRALVETLRKELS--------------------------- 235

  Fly  1453 KKKRHKVTDTRITPRTVSRILAQDGVVPPTGGPPSTPQQQQQQQQQQQQQQQQQQQQASNGGNSN 1517
                          |.||:  |.|.|:......|         |:...||::..|..||.|.|..
Mouse   236 --------------RAVSQ--AVDSVLQQVLFDP---------QRHLTQQERSCQGLASEGRNQP 275

  Fly  1518 ATPAQSPTRSSGGAAYHP---QPP------------PPPPPMMPVS---LPTSVAIPNPSLHESK 1564
            :.|.:|..:.....|..|   ||.            |...||.|||   :|.|...|.|:...:.
Mouse   276 SPPGRSAYKDPLALATLPRKIQPQAGVPLGNSTLARPLDSPMCPVSPRGVPRSYQSPLPNCPLTN 340

  Fly  1565 VFS------------------------PYSPFFNPHAAAGQATAAQLHQHHQQHHPHHQSMQLSS 1605
            |.|                        |....|..|.:...|        .|......|.:.||.
Mouse   341 VPSHTWENQMLRQLLGRGPDGQWSGSPPQDAAFQSHTSPESA--------QQPWGLSQQQLPLSL 397

  Fly  1606 SPPGSLGALMDSRDSPPLPHPPSMLHPALLAAAHHGGSPDYKTCLRAVMDAQDRQSECNSADMQF 1670
            :|     ..::||   |||.|..|                .:..||.|.|:
Mouse   398 TP-----VHLESR---PLPPPVKM----------------EQGVLRGVADS-------------- 424

  Fly  1671 DGMAPTSST-----LTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREF 1730
               .|.||.     |:|.||:|||||||:.|||||::||.||||::||:..|:|::|||||||||
Mouse   425 ---LPFSSIHIQEGLSPGHLKKAKLMFFFTRYPSSSLLKAYFPDVQFNRCITSQMIKWFSNFREF 486

  Fly  1731 YYIQMEKYARQAVTEGIKTPDDLLIAGDSELYRVLNLHYNRNNHIEVPQNFRFVVESTLREFFRA 1795
            ||||||||||||:::||.....|.:..||||:||||.|||:.|..|||..|..:...||:|||||
Mouse   487 YYIQMEKYARQALSDGITNAQALAVLRDSELFRVLNTHYNKGNDFEVPDCFLEIAALTLKEFFRA 551

  Fly  1796 IQGGKDTEQSWKKSIYKIISRMDDPVPEYFKSPNFLEQL 1834
            :..|||::.||||.|||:||::|..|||..|||:||..|
Mouse   552 VLAGKDSDPSWKKPIYKVISKLDSDVPEMLKSPSFLPGL 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pros	NP_001247045.1	COG4372	821..>891	CDD:443500
		HPD	1679..1832	CDD:461534	93/157 (59%)
Prox2	NP_780407.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..48		7/31 (23%)
		PHA03247	<27..443	CDD:223021	109/578 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	79..130		5/50 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..199		13/46 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..284		8/23 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..333		9/34 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..388		5/39 (13%)
		Homeo-Prospero. /evidence=ECO:0000255|PROSITE-ProRule:PRU01162	433..591		95/158 (60%)
		HPD	435..587	CDD:461534	92/151 (61%)