DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pros and Prox2

DIOPT Version :9

Sequence 1:	NP_001247045.1	Gene:	pros / 41363	FlyBaseID:	FBgn0004595	Length:	1835	Species:	Drosophila melanogaster
Sequence 2:	NP_001348167.1	Gene:	Prox2 / 73422	MGIID:	1920672	Length:	593	Species:	Mus musculus

Alignment Length:	754	Identity:	206/754 - (27%)
Similarity:	288/754 - (38%)	Gaps:	257/754 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1167 LFSKQADSVTAAAEQLNKDLLLASQILDRKSPRTKVADRPQ--NGPTPATQSGNNGSLLLAN--- 1226
            |...|:.:.|..||:...|        ..:||.|..|.|..  :|..|::      ||..|:
Mouse     8 LLPPQSRTCTHLAEETCMD--------QERSPATAEAGRDSFPSGQLPSS------SLTEADWFW 58

  Fly  1227 ------SQMPSQTTASG------SSAQQQQQQNAQQQHQGSQQQQQQNVVQQQ------------ 1267
                  .:...:|...|      ||...:.:::.:...:|.:::::|::...|
Mouse    59 DEHIQAKRARVETIVRGMCLSPSSSVSGRARESLRCPEKGRERKRKQSLPMHQGPLKSSPAWERG 123

  Fly  1268 ------NVAQQQHMQQQQQQQQSHPLLPPNCQQLISAPRLNGSQLSFASPAAAAAAAMGLQMHHA 1326
                  .|.:|.|:.:||.:.                                      ||.|
Mouse   124 PKKGGTRVKEQLHLLKQQLRH--------------------------------------LQEH-- 148

  Fly  1327 AAAAAMSAQQQQQQSGDPGANTNPNSGP-ANPTNSSLS---TLNIPPPHIRPSPTAAAMFQAPKT 1387
                .:.|.:.:..:..|| .|.|.|.| |.|.||..|   |:...|..........|
Mouse   149 ----VLQATEPRAPAQSPG-GTEPRSSPRARPRNSCSSGAWTVENEPHQSSSKDLCGA------- 201

  Fly  1388 PQGMNPVAAAALYNSMTGPFCLPPDQQQQQQTAQQQQSAQQQQQSSQQTQQQLEQNEALSLVVTP 1452
               :.|.||..|..| ..|...|...:...:|.:::.|
Mouse   202 ---VKPGAAEVLQYS-EEPMLCPSGPRALVETLRKELS--------------------------- 235

  Fly  1453 KKKRHKVTDTRITPRTVSRILAQDGVVPPTGGPPSTPQQQQQQQQQQQQQQQQQQQQASNGGNSN 1517
                          |.||:  |.|.|:......|         |:...||::..|..||.|.|..
Mouse   236 --------------RAVSQ--AVDSVLQQVLFDP---------QRHLTQQERSCQGLASEGRNQP 275

  Fly  1518 ATPAQSPTRSSGGAAYHP---QPP------------PPPPPMMPVS---LPTSVAIPNPSLHESK 1564
            :.|.:|..:.....|..|   ||.            |...||.|||   :|.|...|.|:...:.
Mouse   276 SPPGRSAYKDPLALATLPRKIQPQAGVPLGNSTLARPLDSPMCPVSPRGVPRSYQSPLPNCPLTN 340

  Fly  1565 VFS------------------------PYSPFFNPHAAAGQATAAQLHQHHQQHHPHHQSMQLSS 1605
            |.|                        |....|..|.:...|        .|......|.:.||.
Mouse   341 VPSHTWENQMLRQLLGRGPDGQWSGSPPQDAAFQSHTSPESA--------QQPWGLSQQQLPLSL 397

  Fly  1606 SPPGSLGALMDSRDSPPLPHPPSMLHPALLAAAHHGGSPDYKTCLRAVMDAQDRQSECNSADMQF 1670
            :|     ..::||   |||.|..|                .:..||.|.|:
Mouse   398 TP-----VHLESR---PLPPPVKM----------------EQGVLRGVADS-------------- 424

  Fly  1671 DGMAPTSST-----LTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREF 1730
               .|.||.     |:|.||:|||||||:.|||||::||.||||::||:..|:|::|||||||||
Mouse   425 ---LPFSSIHIQEGLSPGHLKKAKLMFFFTRYPSSSLLKAYFPDVQFNRCITSQMIKWFSNFREF 486

  Fly  1731 YYIQMEKYARQAVTEGIKTPDDLLIAGDSELYRVLNLHYNRNNHIEVPQNFRFVVESTLREFFRA 1795
            ||||||||||||:::||.....|.:..||||:||||.|||:.|..|||..|..:...||:|||||
Mouse   487 YYIQMEKYARQALSDGITNAQALAVLRDSELFRVLNTHYNKGNDFEVPDCFLEIAALTLKEFFRA 551

  Fly  1796 IQGGKDTEQSWKKSIYKIISRMDDPVPEYFKSPNFLEQL 1834
            :..|||::.||||.|||:||::|..|||..|||:||..|
Mouse   552 VLAGKDSDPSWKKPIYKVISKLDSDVPEMLKSPSFLPGL 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pros	NP_001247045.1	HPD	1679..1830	CDD:282848	92/155 (59%)
Prox2	NP_001348167.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..48		7/31 (23%)
		PHA03247	<27..443	CDD:223021	109/578 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..130		5/50 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..199		13/46 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..284		8/23 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..333		9/34 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..388		5/39 (13%)
		Homeo-Prospero. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01162	433..591		95/158 (60%)
		HPD	435..586	CDD:368261	92/150 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847471
Domainoid	1	1.000	208	1.000	Domainoid score	I2858
eggNOG	1	0.900	-	-		E1_KOG3779
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003482
OrthoInspector	1	1.000	-	-		otm42736
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12198
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2572
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.920