DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pros and prox3

DIOPT Version :9

Sequence 1:	NP_001247045.1	Gene:	pros / 41363	FlyBaseID:	FBgn0004595	Length:	1835	Species:	Drosophila melanogaster
Sequence 2:	NP_001165058.1	Gene:	prox3 / 564431	ZFINID:	ZDB-GENE-050107-3	Length:	659	Species:	Danio rerio

Alignment Length:	803	Identity:	205/803 - (25%)
Similarity:	310/803 - (38%)	Gaps:	212/803 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1082 APRPQMHHPAPARLPTRM------GGAAGHTALKSELSEK--FQMLRANNNSSMMRMSGTDLEGL 1138
            :|..:.|.......|..:      ...:||......||..  |..|...|:.|....|....:||
Zfish     3 SPSDRFHQQPSQMCPFELYRSLPDSNPSGHRFPPGSLSSHPLFSPLMHPNSMSQKWGSFRQRQGL 67

  Fly  1139 ADVLKSEITTSLSALVDTIVTRFVHQRRLFSKQADSVTAAAEQLNKDLLLASQILDRKSPRTKV- 1202
            ...|          |||..|:    :..:|.|:....|:::::.:.:...|.:..|......:|
Zfish    68 FPGL----------LVDDDVS----EEDVFGKREFGATSSSQRGSGERGQAPEPSDWGQDFARVK 118

  Fly  1203 ---ADRPQNGPTPATQSGNNGSLLLANSQMPSQTTASGSSAQQQQQQNAQQQHQGSQQQQQQNVV 1264
               .|........:.:.|..|....::.:|..:        :..:|.|.::..:|.::|:|:..:
Zfish   119 RLRMDSAARSEDESIREGKRGRKSRSSFRMDEK--------KGMEQGNRRESREGRKRQRQELKL 175

  Fly  1265 Q-----------QQNVAQQQHMQQQQQQQQSHPLLPPNCQQLISAPRLNGSQLSFASPAAAAAAA 1318
            |           |:.|.:....|...::.|.                 ||
Zfish   176 QLEETRGKLLELQRKVWRVYGGQADDEKDQE-----------------NG--------------- 208

  Fly  1319 MGLQMHHAAAAAAMSAQQQQQQSGDP--GANTNP---NSGPANPTNSSLSTLNIPPPHIRPSPTA 1378
             |:.:...|        .....|.||  |...:|   :|...|.||.:.:
Zfish   209 -GINLDEVA--------DMFSDSDDPLVGNGFSPQRCSSKKNNETNGNGN--------------- 249

  Fly  1379 AAMFQAPKTPQGMNPVAAAALYNSMTGPFCLPPDQQQQQQTAQQQQSAQQQQQSSQQTQQQL--- 1440
            |.:|  |:|...::    ..|..|.....|        .....:.:||:..|:.:|..:|:|
Zfish   250 AGIF--PETSVDLD----LELNGSQVWLGC--------SLIRGEWESAEGGQKFAQALKQELANV 300

  Fly  1441 --------------EQNEALSLVVTPKKKRHKVTDTRITPRTVSRILAQDGVVPPTGGPPSTPQQ 1491
                          ...||:|....|.......:|.|..|:.|.::.|    :|.....|
Zfish   301 VAQVIDRVVRLYAESDPEAVSSAQEPSMTMDLNSDRRPRPQAVEQVEA----LPLVTKSP----- 356

  Fly  1492 QQQQQQQQQQQQQQQQQQASNGGNSNATPAQSPTRSSGGAAYHPQPPPPPPPMMPVSLPTSVAIP 1556
                       |.::...|.:|......|..:|:.:       |...||.|.::|         |
Zfish   357 -----------QDKRAPVAQSGHKDLLLPQANPSLA-------PLAQPPLPALLP---------P 394

  Fly  1557 NPSLHESKVFSPYSPFFNP-HAAAGQATAAQLHQHHQQHHPHHQSMQLSSSPPGSLGALMDSRDS 1620
            ....|    |.|..|..|| |......|...|........|.|:.. ||.|       .||.|..
Zfish   395 RGKEH----FLPSYPPDNPVHLPLLHYTMQNLFARSLSSLPLHKDC-LSES-------FMDFRSH 447

  Fly  1621 ----PPLP----HPPSMLHPALLAAAHHGGSPDYKTCLRAVMDAQDRQSECNSADMQFDGMAPTS 1677
                ||||    ..||....|.......||:        .::|..|......:...| :|
Zfish   448 NSAFPPLPLLGQLDPSPSDRAREVGMRAGGA--------GMVDGADAALYLAAGSSQ-EG----- 498

  Fly  1678 STLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREFYYIQMEKYARQA 1742
              |:|.||:|||||||:.|||||:.||.||||:|||:..|:||:|||||||||:|||||::||||
Zfish   499 --LSPCHLKKAKLMFFYTRYPSSSTLKTYFPDVKFNRCVTSQLIKWFSNFREFFYIQMERFARQA 561

  Fly  1743 VTEGIKTPDD--LLIAGDSELYRVLNLHYNRNNHIEVPQNFRFVVESTLREFFRAIQGGKDTEQS 1805
            ..|.:.:..:  |.:..|:||||:||:|||::|..:||:.|..:.|..|||||.|||.|:|.:..
Zfish   562 AREVLTSARERALRLGRDTELYRILNMHYNKSNDYQVPERFVEISEVALREFFTAIQSGRDADPC 626

  Fly  1806 WKKSIYKIISRMDDPVPEYFKSP 1828
            |||||||||.::|.|||:.|:.|
Zfish   627 WKKSIYKIICKLDSPVPDSFRLP 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pros	NP_001247045.1	HPD	1679..1830	CDD:282848	88/152 (58%)
prox3	NP_001165058.1	HPD	498..651	CDD:282848	89/159 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592751
Domainoid	1	1.000	205	1.000	Domainoid score	I2882
eggNOG	1	0.900	-	-		E1_KOG3779
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003482
OrthoInspector	1	1.000	-	-		otm26310
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12198
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.890