DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pros and PROX1

DIOPT Version :9

Sequence 1:	NP_001247045.1	Gene:	pros / 41363	FlyBaseID:	FBgn0004595	Length:	1835	Species:	Drosophila melanogaster
Sequence 2:	XP_005273251.1	Gene:	PROX1 / 5629	HGNCID:	9459	Length:	738	Species:	Homo sapiens

Alignment Length:	1066	Identity:	252/1066 - (23%)
Similarity:	373/1066 - (34%)	Gaps:	389/1066 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   825 DSESNELESPQIQQKRVEKNALKSQLRSMQEQLAEMQQKYVQLCSRMEQESECQELDQDQDVEQE 889
            |.:|..|.|.|.:::||: ..:|..:.:.....|:.:..:.   |.|..:.      .:||||..
Human     3 DHDSTALLSRQTKRRRVD-IGVKRTVGTASAFFAKARATFF---SAMNPQG------SEQDVEYS 57

  Fly   890 --QEPDNGSSDHIE------------LSPSPTLTGDGDVSPNHKEETGQERP-----GSSSPSPS 935
              |..|...|:.:.            :.|.|..|....:..|:..:.|...|     |.||....
Human    58 VVQHADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTGSE 122

  Fly   936 PLKPKTSLGESSDSGANMLSQMMSKMMS----------------GKLHNPLVGVGHPALPQGFPP 984
            ..:.......|.||....||......||                .::.|.:.|:.|       .|
Human   123 VHQEDICSNSSRDSPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSH-------SP 180

  Fly   985 LLQHMGDMSHAAAMYQQFFFEQEARMA------KEAAEQQQQQQQQQQQQQQQQQQEQQRRFEQE 1043
            .:...|:             |.|..||      :|:..:.:::|:..|||||..||....|.||:
Human   181 SVALRGN-------------ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQK 232

  Fly  1044 QQEQQRRKEEQQQQIQRQQQHLQQLQQQQMEQQHVATAAPRPQMHHPAPARLPTRMGGAAGHTAL 1108
            ::|:::.|    ||::..|:.|:|||
Human   233 REERRQLK----QQLEDMQKQLRQLQ--------------------------------------- 254

  Fly  1109 KSELSEKFQMLRANNNSSMMRMSGTDLEG--LADVLKSEITTSLSALVDTIVTRFVHQRRLFSKQ 1171
                 |||..:..:.:|.      .|.:|  ..|.::|||                    |.::.
Human   255 -----EKFYQIYDSTDSE------NDEDGNLSEDSMRSEI--------------------LDARA 288

  Fly  1172 ADSVTAAAEQLNKDLLLASQILDRKSPRTKVADRPQNGPTPATQSGNNGSLLLANSQMPSQTTAS 1236
            .|||..:..::.:  |...|.:||.....:..:..:|.|   .:.|||..    ....|:.....
Human   289 QDSVGRSDNEMCE--LDPGQFIDRARALIREQEMAENKP---KREGNNKE----RDHGPNSLQPE 344

  Fly  1237 GSSAQQQQQQNAQQQHQGSQQQQQQNVVQQQNVAQQQHMQQQQQQQQSHPLLPPNCQQLISAPR- 1300
            |             :|.....:|:.|....|.|.....:...:..:|...:.||     :..|:
Human   345 G-------------KHLAETLKQELNTAMSQVVDTVVKVFSAKPSRQVPQVFPP-----LQIPQA 391

  Fly  1301 ---LNGSQLSFASPAAAAAAAMGLQMHHAAAAAAMSAQQQQQQSGDPGANTNPNSGPANPTNSSL 1362
               :||...:|                |       :|.|:.|..||
Human   392 RFAVNGENHNF----------------H-------TANQRLQCFGD------------------- 414

  Fly  1363 STLNIPPPHIRPSPTAAAMFQAPKTPQGMNPVAAAALYNSMTGPFCLPPDQQQQQQTAQQQQSAQ 1427
              :.||                       ||:
Human   415 --VIIP-----------------------NPL--------------------------------- 421

  Fly  1428 QQQQSSQQTQQQLEQNEALSLVVTPKKKRHKVTDTRITPRTVSRILAQDGVVPPTGGPPSTPQQQ 1492
             ....:.|.....:|.|||.|||
Human   422 -DTFGNVQMASSTDQTEALPLVV------------------------------------------ 443

  Fly  1493 QQQQQQQQQQQQQQQQQASN--GGNSNATPAQSPTRSSGGAAYHPQPPPPPPPMMPVSLPTSVAI 1555
                     ::....|.||.  .|..:....|||..::.|........|.|.|:|.....:.:..
Human   444 ---------RKNSSDQSASGPAAGGHHQPLHQSPLSATTGFTTSTFRHPFPLPLMAYPFQSPLGA 499

  Fly  1556 PNPSLHESKVFSPYSPFFNPHAAAGQATAAQLHQHHQQHHPHHQSMQLSSSPPGSLGALMDSRDS 1620
            |:.|.......||.|........   :...::..||..|||        .||
Human   500 PSGSFSGKDRASPESLDLTRDTT---SLRTKMSSHHLSHHP--------CSP------------- 540

  Fly  1621 PPLPHPPSMLHPALLAAAHHGGSPDYKTCLRAVMDAQDRQSECNSADMQ-FDGMAPTSST----- 1679
               .||||......|:..                     :|||  .|:| ...::|.|.:
Human   541 ---AHPPSTAEGLSLSLI---------------------KSEC--GDLQDMSEISPYSGSAMQEG 579

  Fly  1680 LTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREFYYIQMEKYARQAVT 1744
            |:|.||:|||||||:.|||||.:||.||.|:|||:..|:||:|||||||||||||||||||||:.
Human   580 LSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAIN 644

  Fly  1745 EGIKTPDDLLIAGDSELYRVLNLHYNRNNHIE-VPQNFRFVVESTLREFFRAIQGGKDTEQSWKK 1808
            :|:.:.::|.|..|.||||.||:|||:.|..| ||:.|..|.:.||||||.||..|||.:.||||
Human   645 DGVTSTEELSITRDCELYRALNMHYNKANDFEQVPERFLEVAQITLREFFNAIIAGKDVDPSWKK 709

  Fly  1809 SIYKIISRMDDPVPEYFKSPNFLEQL 1834
            :|||:|.::|..|||.|||||.|::|
Human   710 AIYKVICKLDSEVPEIFKSPNCLQEL 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pros	NP_001247045.1	HPD	1679..1830	CDD:282848	94/156 (60%)
PROX1	XP_005273251.1	HPD	579..731	CDD:398635	94/151 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157064
Domainoid	1	1.000	208	1.000	Domainoid score	I2866
eggNOG	1	0.900	-	-		E1_KOG3779
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5769
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003482
OrthoInspector	1	1.000	-	-		otm40662
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12198
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2572
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.910