DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pros and Prox1

DIOPT Version :9

Sequence 1:	NP_001247045.1	Gene:	pros / 41363	FlyBaseID:	FBgn0004595	Length:	1835	Species:	Drosophila melanogaster
Sequence 2:	NP_001100671.1	Gene:	Prox1 / 305066	RGDID:	1306890	Length:	583	Species:	Rattus norvegicus

Alignment Length:	593	Identity:	120/593 - (20%)
Similarity:	207/593 - (34%)	Gaps:	176/593 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   651 SLDSHGAQDDAQDEEDAAPTGQRS--------ESRAPEEPQLPTKKESVDDML------------ 695
            :::..|::.|.:........|::|        .:.:.|:..:|....::...|
  Rat    44 AMNPQGSEQDVEYSVVQHADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTE 108

  Fly   696 DEVELLGLHSRGSDM--DSLASPSHSD-------------MMLLDKDDVLDEDDDDDCVEQKTSG 745
            ...:..||.|.||::  :.:.|.|..|             |...|.|.:.||.
  Rat   109 PSFQASGLSSTGSEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDVDRLCDEH------------ 161

  Fly   746 SGCLKKPGMDLKRARVENIVSGMRCSPSSGLAQAGQLQVNGCKKRKLYQPQQHAMERYVAAAAGL 810
                    :..||||||||:.||..|||..|        .|.:..:...||        :.:...
  Rat   162 --------LRAKRARVENIIRGMSHSPSVAL--------RGNENEREMAPQ--------SVSPRE 202

  Fly   811 NFGLNLQSMMLDQEDSES-NELESPQIQQKRVEKNALKSQLRSMQEQLAEMQQKYVQLCSRMEQE 874
            ::..|.:...|.|:..:| .:|.|.:.:|||.|:..||.||..||:||.::|:|:.|:....:.|
  Rat   203 SYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQVYDSTDSE 267

  Fly   875 SECQELDQDQDVEQEQ----------EPDNGSSDH--IELSP------SPTLTGDGDVSPNHKEE 921
            :     |:|.|:.::.          :...|.||:  .||.|      :..|..:.:::.|..:.
  Rat   268 N-----DEDGDLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKR 327

  Fly   922 TGQERPGSSSPSPSPLKPK-----TSLGESSDSGANMLSQMMSKMMSGKLHNPLVGVGHPA--LP 979
            .|..:  .....|:.|:|:     .:|.:..::..:.:...:.|:.|.|          |:  :|
  Rat   328 EGSNK--ERDHGPNSLQPEGKHLAETLKQELNTAMSQVVDTVVKVFSAK----------PSRQVP 380

  Fly   980 QGFPPLLQHMGDMSHAAAMYQQFFFEQEARMAKEAAEQQQQQQQQQQQQQQ-------------- 1030
            |.||||                     :...|:.|...:........|:.|
  Rat   381 QVFPPL---------------------QIPQARFAVNGENHNFHTANQRLQCFGDVIIPNPLDTF 424

  Fly  1031 --QQQQEQQRRFEQEQQEQQRRKEEQQQQIQRQQQHLQQLQQQQMEQQHVATAA-PRPQMHHPAP 1092
              .|......:.|......::...||.........|.|.|.|..:.    |||. ..|...||.|
  Rat   425 GNVQMPSSTDQTEALPLVVRKNSSEQSASGPATGGHHQPLHQSPLS----ATAGFTTPSFRHPFP 485

  Fly  1093 ARL-----PTRMGGAAGHTALKSELSEKFQMLRANNNSSMMRMSGTDL--------------EGL 1138
            ..|     .:.:|..:|..:.|...|.:...|..:..|...:||...|              |||
  Rat   486 LPLMAYPFQSPLGAPSGSFSGKDRASPESLDLTRDTTSLRTKMSSHHLSHHPCSPAHPPSTAEGL 550

  Fly  1139 A-DVLKSE 1145
            : .::|||
  Rat   551 SLSLIKSE 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
pros	NP_001247045.1	HPD	1679..1830	CDD:282848
Prox1	NP_001100671.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351022
Domainoid	1	1.000	208	1.000	Domainoid score	I2761
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003482
OrthoInspector	1	1.000	-	-		otm44800
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12198
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.030