DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pros and prox1

DIOPT Version :9

Sequence 1:	NP_001247045.1	Gene:	pros / 41363	FlyBaseID:	FBgn0004595	Length:	1835	Species:	Drosophila melanogaster
Sequence 2:	XP_012819403.1	Gene:	prox1 / 100134995	XenbaseID:	XB-GENE-485327	Length:	740	Species:	Xenopus tropicalis

Alignment Length:	1388	Identity:	282/1388 - (20%)
Similarity:	411/1388 - (29%)	Gaps:	696/1388 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   476 RRVSACSDRSLEAAAADVAGGSPPRAASVSSLNGGASSGEQHQSQLQH-DLVAHHMLRNILQ--- 536
            |||.....|::..|:|..|   ..||...|::|...|..:...|.:|| |....::||.:|:
Frog    17 RRVDIGVKRTVGTASAFFA---KARATFFSAMNPQGSEHDVEYSVVQHTDGEKSNVLRKLLKRAN 78

  Fly   537 ----------GKKELMQLDQELRTAMQQQQQQLQEKEQLHSKLNNNNNNNIAATANNNNNTTMES 591
                      |...:.||                        |.||.|.|..
Frog    79 SYEDAMMPFPGATIISQL------------------------LKNNMNKNCG------------- 106

  Fly   592 INLIDDSEMADIKIKSEPQTAPQPQQSPHGSSHSSRSGSGSGSHSSMASDGSLRRKSSDSLDSHG 656
                               |.|..|.       |..|.:||..|
Frog   107 -------------------TEPSFQA-------SGLSSAGSEIH--------------------- 124

  Fly   657 AQDDAQDEEDAAPTGQRSESRAPEEPQLPTKKESVDDMLDEVELLGLHSRGSDMDSLASPSHSDM 721
                   :|||.....|.   :|:|...|..:.:::..              |||.|
Frog   125 -------QEDACSNSSRD---SPQECLSPFGRPTMNQY--------------DMDRL-------- 157

  Fly   722 MLLDKDDVLDEDDDDDCVEQKTSGSGCLKKPGMDLKRARVENIVSGMRCSPSSGLAQAGQLQVNG 786
                            |.|.            :..||||||||:.||..||:..| :..:...:|
Frog   158 ----------------CDEH------------LRAKRARVENIIRGMSHSPNVAL-RGNENDRDG 193

  Fly   787 CKKRKLYQPQQHAMERYVAAAAGLNFGLNLQSMMLDQEDSES-NELESPQIQQKRVEKNALKSQL 850
            ..:.  ..|::...|             |.:...|.|:..:| .:|.|.:.:|||.|:..||.||
Frog   194 APRS--VSPRESYRE-------------NKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQL 243

  Fly   851 RSMQEQLAEMQQKYVQLCSRMEQESECQELDQDQDVEQEQEPDNGSSDHIELSPSPTLTGDGDVS 915
            ..||:||.::|:|:.|:....:.|:     ::|.::.:    |:..|:.||
Frog   244 EDMQKQLRQLQEKFYQIYDSTDSEN-----NEDGNLSE----DSMHSEIIE-------------- 285

  Fly   916 PNHKEETGQERPGSSSPSPSPLKPKTSLGESSDSGANMLSQMMSKMMSGKLHNPLVGVGHPALPQ 980
                                 .:.:.|:|.|.
Frog   286 ---------------------ARARDSMGRSD--------------------------------- 296

  Fly   981 GFPPLLQHMGDMSHAAAMYQQFFFEQEARMAKEAAEQQQQQQQQQQQQQQQQQQEQQRRFEQEQQ 1045
                  ..|.|:..|     ||.....|
Frog   297 ------HEMFDLDPA-----QFIDRARA------------------------------------- 313

  Fly  1046 EQQRRKEEQQQQIQRQQQHLQQLQQQQMEQQHVATAAPRPQMHHPAPARLPTRMGGAAGHTALKS 1110
                                       :.::|...:...|:...|..                |.
Frog   314 ---------------------------LIREHEIASDNHPKKDGPKD----------------KD 335

  Fly  1111 ELSEKFQMLRANNNSSMMRMSGTDLEGLADVLKSEITTSLSALVDTIVTRFVHQRRLFSKQADSV 1175
            .|...||               .:.:.||:.||.|:.|::|.:|||:|       ::||.:
Frog   336 NLHHNFQ---------------PESKHLAEALKQELNTAMSQVVDTVV-------KVFSAK---- 374

  Fly  1176 TAAAEQLNKDLLLASQILDRKSPRTKVADRPQNGPTPATQSGNNGSLLLANSQMPSQTTASGSSA 1240
                                     .:...||..|.               .|||
Frog   375 -------------------------PIRQLPQVFPP---------------IQMP---------- 389

  Fly  1241 QQQQQQNAQQQHQGSQQQQQQNVVQQQNVAQQQHMQQQQQQQQSHPLLPPNCQQLISAPRLNGSQ 1305
                              |.:..:..:|  ...|...|:.|.....::|.......:.|..:.:.
Frog   390 ------------------QARFAISGEN--HNFHTTNQRLQCFGDVIIPNPLDTFSNVPLPSSTD 434

  Fly  1306 LSFASPAAAAAAAMGLQMHHAAAAAAMSAQQQQQQSGDPGANTNPNSGPANPTNSSLSTLNIPP- 1369
            .:.|.|...                       ::.|.|..|     |||             ||
Frog   435 QTEALPLVV-----------------------RKNSNDQSA-----SGP-------------PPG 458

  Fly  1370 ---PHIRPSP-TAAAMFQAPKTPQGMNPVAAAALYNSMTGPFCLPPDQQQQQQTAQQQQSAQQQQ 1430
               |.:..|| :|||.|.:                :|...||.||
Frog   459 SHHPVLHQSPLSAAASFSS----------------SSFRHPFPLP-------------------- 487

  Fly  1431 QSSQQTQQQLEQNEALSLVVTPKKKRHKVTDTRITPRTVSRILAQDGVVPPTGGPPSTPQQQQQQ 1495
                             |:..|.:.                         |.|.|.|.
Frog   488 -----------------LMAYPFQN-------------------------PLGAPSSA------- 503

  Fly  1496 QQQQQQQQQQQQQQASNGGNSNATPAQSPTRSSGGAAYHPQPPPPPPPMMPVSLPTSVAIPNPSL 1560
                                     .|...|||             |..:.::..|:
Frog   504 -------------------------FQGKDRSS-------------PESLDLTRETT-------- 522

  Fly  1561 HESKVFSPYSPFFNPHAAAGQATAAQLHQHHQQHHPHHQSMQLSSSPPGSLGALMDSRDSPPLPH 1625
                                 :...::..||..|||        .||                .|
Frog   523 ---------------------SLRTKMSSHHMNHHP--------CSP----------------AH 542

  Fly  1626 PPSMLHPALLAAAHHGGSPDYKTCLRAVMDAQDRQSECNSADMQ-FDGMAPTSST-------LTP 1682
            |||......|:..                     :|||  .||| ...::|.|.:       |:|
Frog   543 PPSSTEGLSLSFI---------------------KSEC--GDMQDMSDISPYSGSALYMQEGLSP 584

  Fly  1683 MHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREFYYIQMEKYARQAVTEGI 1747
            .||:|||||||:.|||||.:||.:|.|:|||:..|:||:|||||||||||||||||||||:.:||
Frog   585 NHLKKAKLMFFYTRYPSSNMLKTFFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGI 649

  Fly  1748 KTPDDLLIAGDSELYRVLNLHYNRNNHIE-VPQNFRFVVESTLREFFRAIQGGKDTEQSWKKSIY 1811
            .:.::|.|..|.||||.||:|||:.|..| ||:.|..|.:.||||||.||..|||.:.||||:||
Frog   650 TSTEELCITRDCELYRALNMHYNKANDFEQVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIY 714

  Fly  1812 KIISRMDDPVPEYFKSPNFLEQL 1834
            |:|.::|..||:.|:|||.|::|
Frog   715 KVICKLDSEVPDIFRSPNCLQEL 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pros	NP_001247045.1	HPD	1679..1830	CDD:282848	92/158 (58%)
prox1	XP_012819403.1	HPD	581..733	CDD:282848	92/151 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	205	1.000	Domainoid score	I2873
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003482
OrthoInspector	1	1.000	-	-		oto102807
Panther	1	1.100	-	-	LDO	PTHR12198
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2572
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.130