Protein Alignment KP78a and YPL150W

DIOPT Version :10

• Sequence 1: NP_650066.1
• Gene: KP78a / 41362
• FlyBaseID: FBgn0026064
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_015175.1
• Gene: YPL150W / 855953
• SGDID: S000006071
• Length: 901
• Species: Saccharomyces cerevisiae
• Alignment Length: 579
• Identity: 160/579 - (27%)
• Similarity: 267/579 - (46%)
• Gaps: 101/579 - (17%)

  Fly    78 SSKNTDSKFQSYVNGNGN--------------GVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKV 128
            |||...:..:|.:..:.|              |.|||:|.:|:|:|.||.||:|.||.|:|.:|.
Yeast     7 SSKLEQNNIKSIIGSSYNRLYSQFTSDELTEVGNYKILKQIGEGSFGKVYLALHRPTHRKVCLKT 71

  Fly   129 IDKTQLNTSARQKLYREVKIMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMR 193
            .||...|      :.|||...:..:.|.|.:|::||.:|..:::.:||....||:|||:...|:.
Yeast    72 SDKNDPN------IVREVFYHRQFDFPYITKLYEVIVTESKVWMALEYCPGKELYDHLLSLRRIS 130

  Fly   194 ERDARVIFRQLVSAIQYCHSKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSP 258
            ..:...:|.|:..|:.|.||...||||||.||:|||::.|.|:.||||.........|||.||:.
Yeast   131 LLECGELFAQISGAVYYAHSMHCVHRDLKLENILLDKNGNAKLTDFGFTRECMTKTTLETVCGTT 195

  Fly   259 PYAAPELFMGRKYAGPEVDAWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYY----IS 319
            .|.||||...|.|.|.::|.|||||:||||::|.||||.....:.:.:::..:   |.|    |.
Yeast   196 VYMAPELIERRTYDGFKIDIWSLGVILYTLITGYLPFDDDDEAKTKWKIVNEE---PKYDAKVIP 257

  Fly   320 MDCENLMRKFLVLNPAKRTSLSAVMSDKWI----NLGHDESDRL--------RPFREKPMELQDA 372
            .|..:|:.:.|..||.:|.|||.|:...::    ::..|::.::        ..|:.| :|.:..
Yeast   258 DDARDLISRLLAKNPGERPSLSQVLRHPFLQPYGSVVLDQTQKILCRQRSGGTQFKSK-LERRLL 321

  Fly   373 ARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLLGVAKPRSSNRSTKPEAIPTVDLTTPAVSSP 437
            .|   |...|...:.::||:..:..|.:...::|| :|:.:.......|:...:|......:.|.
Yeast   322 KR---LKQSGVDTQAIKQSILKKKCDSLSGLWLLL-LAQGKKQENCKYPKRSRSVLSVKKVIESA 382

  Fly   438 LPNITT--------PTVTI---AHVTLALDKNPPIHSSSASGRPIAPRLANAPNTPTSTPPTGPP 491
            ..|.|.        |::.:   |.::..|:|.....:|.               ||.|...:...
Yeast   383 THNDTNGISEDVLKPSLELSRAASLSKMLNKGSDFVTSM---------------TPVSRKKSKDS 432

  Fly   492 AKPTRRTPARTPARKATNHT-SGQGR------PEPSSLPHTPQSKRASAN----MDVKPTLLSAQ 545
            ||....|.::..:::|.:|: :|..|      .:.||...:.:|..:::|    .:|..:|:::.
Yeast   433 AKVLNPTLSKISSQRAYSHSIAGSPRKSNNFLQKVSSFFKSKKSSNSNSNNSIHTNVSESLIASN 497

  Fly   546 R----------------QLAQTQKLANTPPRFQYPVAQTPNQAQG---SSRRPTTLYEK 585
            |                |.::|..:|| |.|.:...:...|.|..   .|...|||..|
Yeast   498 RGAPSSGSFLKKNSGSIQKSRTDTVAN-PSRTESIGSLNENVAGAIVPRSANNTTLENK 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	Protein Kinases, catalytic domain	98..349	CDD:473864	101/254 (40%)
		UBA_MARK_Par1	370..408	CDD:270522	7/37 (19%)
YPL150W	NP_015175.1	STKc_AMPK-like	40..286	CDD:270905	101/254 (40%)