Protein Alignment KP78a and Prkaa2

DIOPT Version :10

• Sequence 1: NP_650066.1
• Gene: KP78a / 41362
• FlyBaseID: FBgn0026064
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_076481.2
• Gene: Prkaa2 / 78975
• RGDID: 620893
• Length: 552
• Species: Rattus norvegicus
• Alignment Length: 532
• Identity: 165/532 - (31%)
• Similarity: 250/532 - (46%)
• Gaps: 92/532 - (17%)

  Fly    96 GVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNT-SARQKLYREVKIMKLLNHPNIVR 159
            |.|.:..|||.|.|.|||:..|..||.:||:|::::.::.: ....|:.||::.:||..||:|::
  Rat    14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78

  Fly   160 LFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFVVHRDLKAE 224
            |:|||.:....::||||.|.|||||::.|:||:.|.:||.:|:|::||:.|||...|||||||.|
  Rat    79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPE 143

  Fly   225 NLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSLGVVLYTLV 289
            |:|||..||.||||||..|.......|.|.||||.|||||:..||.|||||||.||.||:||.|:
  Rat   144 NVLLDAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALL 208

  Fly   290 SGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSDKWINLGHD 354
            .|:||||...:..|.:::..|.:.:|.|::.....|:...|.::|.||.::..:...:|..  .|
  Rat   209 CGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSIATLLMHMLQVDPLKRATIKDIREHEWFK--QD 271

  Fly   355 ESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLF-----DDIYCTYMLLGVAKPRS 414
            ....|  |.|.|....:....:.:..:..|....|..|...|:     |.:...|.|: :...|.
  Rat   272 LPSYL--FPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLI-IDNRRI 333

  Fly   415 SNRSTK---------------------------PEAIPTVDLTTPAVSSPLP--NITTPTVTIAH 450
            .|::::                           ||.:|.:...:|....||.  |.|.|.
  Rat   334 MNQASEFYLASSPPTGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPK----- 393

  Fly   451 VTLALDK---NPPIHSSSASGRPIAP------------RLANAPN--TPTSTPPTGPPAKPT--- 495
             :||:.|   :..|.|.|.....:|.            ::.||.:  .....|.||...|.:
  Rat   394 -SLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQL 457

  Fly   496 ---------------------RRTPARTPARKATNHTSGQGRPEPSSLPHTPQSKRASANMD--- 536
                                 :|:.:.||.|..:  .:|..||..|....|.::...|.::.
  Rat   458 YLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCS--AAGLHRPRSSVDSSTAENHSLSGSLTGSL 520

  Fly   537 VKPTLLSAQRQL 548
            ...||.||..:|
  Rat   521 TGSTLSSASPRL 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	Protein Kinases, catalytic domain	98..349	CDD:473864	112/251 (45%)
		UBA_MARK_Par1	370..408	CDD:270522	7/42 (17%)
Prkaa2	NP_076481.2	STKc_AMPK_alpha	13..268	CDD:270981	113/253 (45%)
		UBA_AID_AAPK2	285..349	CDD:270587	9/64 (14%)
		AIS. /evidence=ECO:0000250|UniProtKB:Q13131	291..376		12/85 (14%)
		AMPKA2_C	395..550	CDD:213385	28/140 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	478..520		10/43 (23%)