DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and mark3b

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_009293196.1	Gene:	mark3b / 767634	ZFINID:	ZDB-GENE-060929-80	Length:	834	Species:	Danio rerio

Alignment Length:	663	Identity:	285/663 - (42%)
Similarity:	369/663 - (55%)	Gaps:	111/663 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 GVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKLLNHPNIVRL 160
            |.|:::||:|||||||||||.|:.||||||||:|||||||.::.|||:|||:|||:|||||||:|
Zfish    74 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKL 138

  Fly   161 FQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFVVHRDLKAEN 225
            |:|||:::||||||||||.||:||:||.:|||:|::||..|||:|||:||||.|.:|||||||||
Zfish   139 FEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAEN 203

  Fly   226 LLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSLGVVLYTLVS 290
            ||||..||||||||||.|.|....:|:||||||||||||||.|:||.|||||.|||||:||||||
Zfish   204 LLLDADMNIKIADFGFSNEFTIGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVS 268

  Fly   291 GSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSDKWINLGHDE 355
            |||||||..||||||||||||||:|:|:|.|||||:::||||||.||.:|..:|.|:|||.|.:|
Zfish   269 GSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGCEE 333

  Fly   356 SDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLLG------------ 408
             :.|:||.|..:::.|..|.|:::.||:.|.::.:|:....:|:|..||:|||
Zfish   334 -EELKPFVEPELDISDQKRIDIMVGMGYSREEIHESLTRMKYDEITATYLLLGRKSTELEVSDSS 397

  Fly   409 --------VAKPRS--------------SNRST-------KPEAIPTVDLTTPAVSSPLPNITTP 444
                    .|:|.|              .|.||       ..:|.||:    |:|..|..:.||.
Zfish   398 SSSNLSLAKARPNSEHNNGQSPSHLKVQKNASTNQKQRRYSDQAGPTI----PSVGYPKRSQTTS 458

  Fly   445 TVTIAHVTLALDKNPPIHSSSASG----RPIAPRLANAPNTPTSTPPTGPPAK---PTRRTPART 502
                |......:.:.....||:||    .|.:|.|.||.|          |.|   |.|:..|..
Zfish   459 ----AESEHKEEGSAQARKSSSSGSRGMAPASPMLGNANN----------PNKADIPDRKKSAGA 509

  Fly   503 PARKATNHTSGQGRPEPSSLPHTPQSKRASANMDVKPTLLSAQRQLAQTQKLANTPPRFQYPVAQ 567
            |...:.  :||..|...........:.|.|...:.|...||.......|...|       |.||.
Zfish   510 PGNNSV--SSGMTRRNTYVCSERNATDRHSVIQNGKENSLSEMSGCVSTSPTA-------YAVAL 565

  Fly   568 TPNQAQGSSRRPTTLYEKAEPAVTPLLVPKSPAMG---------ARLLERIPGGGAVEKTSDKP- 622
            ..:.|....|........|........:|.|.|..         |:..:|.||......:|..|
Zfish   566 ASSSASVRLRHQKAASLSASGHTCRATLPTSDASADLFRPNTSTAQTSQRNPGSSTHSISSATPP 630

  Fly   623 ----FTRQNVARATFHFGQARSGKRGGGSGNGAGGEEDSYQTPPLS---ADDTKPASR------V 674
                |.|..::|:|||.||.|..:..            :|..||.|   :.|..|.|:      .
Zfish   631 DRLRFPRGTLSRSTFHGGQLRERRTA------------TYNGPPASPTLSHDATPLSQSRSRGST 683

  Fly   675 GFFSKLTARFGRR 687
            ..|:|||::..||
Zfish   684 NLFTKLTSKLTRR 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	183/250 (73%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	183/250 (73%)
mark3b	XP_009293196.1	STKc_MARK	75..327	CDD:270974	183/251 (73%)
		S_TKc	76..327	CDD:214567	183/250 (73%)
		UBA_MARK3_4	345..387	CDD:270590	14/41 (34%)
		MARK1-3_C	735..832	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26532
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810