Protein Alignment KP78a and Mark4

DIOPT Version :10

• Sequence 1: NP_650066.1
• Gene: KP78a / 41362
• FlyBaseID: FBgn0026064
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_001178000.1
• Gene: Mark4 / 680407
• RGDID: 1591792
• Length: 752
• Species: Rattus norvegicus
• Alignment Length: 699
• Identity: 294/699 - (42%)
• Similarity: 399/699 - (57%)
• Gaps: 101/699 - (14%)

  Fly    18 SEKTAMTAANKENDPDSHFTGTIVTTGATAQPATPTTSNATALPATPTVAAGQDLGDGACSSKNT 82
            |.:||:...|..|. |:|  ||: .:|.::......:|.:.......::|        :|..:
  Rat     2 SSRTALAPGNDRNS-DTH--GTL-GSGRSSDKGPSWSSRSLGARCRNSIA--------SCPEE-- 52

  Fly    83 DSKFQSYVNGNGNGVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVK 147
                |.:|     |.|::::|:|||||||||||.|:.||||||||:|||||||.|:.|||:|||:
  Rat    53 ----QPHV-----GNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVR 108

  Fly   148 IMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCH 212
            |||.|||||||:||:|||:|:||||||||||.||:||:||.:|||:|::||..|||:|||:.|||
  Rat   109 IMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCH 173

  Fly   213 SKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVD 277
            .|.:|||||||||||||...|||||||||.|.|...::|:||||||||||||||.|:||.|||||
  Rat   174 QKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVD 238

  Fly   278 AWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSA 342
            .|||||:|||||||||||||..||||||||||||||||:|:|.|||:::|:|||||||||.:|..
  Rat   239 IWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQ 303

  Fly   343 VMSDKWINLGHDESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLL 407
            :|.|||||:|: |.:.|:|:.|...:..|..|.::::.||:.|.::::::..|.::::..||:||
  Rat   304 IMKDKWINIGY-EGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKEALTNQKYNEVTATYLLL 367

  Fly   408 GVAKPRSSNRSTKPEAIPTVDLTTPAVSSPLPNITTPTVTIAHVTLALDKNPPIHSSS------- 465
            |.......:|..     |.:.|......|...|.|:.:...:|     :|.....||:
  Rat   368 GRKTEEGGDRGA-----PGLALARVRAPSDTTNGTSSSKGSSH-----NKGQRTSSSTYHRQRRH 422

  Fly   466 -----ASGRPIAPRLANAPNTPTSTPPTGPPAKPTRRTPARTPARKATNHTSGQG-RPEPSSLP- 523
                 .|..|:.|:     .:||||       ..|.....|.|.|||:...:|.| |..|.|.|
  Rat   423 SDFCGPSPAPLHPK-----RSPTST-------GDTELKEERLPGRKASCSAAGSGSRGLPPSSPM 475

  Fly   524 ----HTPQSKRASANMDVKPTLLSAQRQLAQTQKLANTPP-----RFQYPVAQTPNQAQGSSRRP 579
                |.|.....            .:|:...|....|.||     |..|...:.|    ||.|:.
  Rat   476 VSSAHNPNKAEI------------PERRKDSTSTPNNLPPSMMTRRNTYVCTERP----GSERQS 524

  Fly   580 TTLYEKAEPAVTPLLVPKSPAMGARLLERIPGGGAVEKTSDKPFTRQNVARATFHFGQARSGKRG 644
            .....|...:.|..:.|.||:..:    ..|..|...:     ..|.:..|:|||.||.|..:.|
  Rat   525 LLPNGKENSSGTSRVPPASPSSHS----LAPPSGERSR-----LARGSTIRSTFHGGQVRDRRAG 580

  Fly   645 GGSGNGA-GGEEDS----YQTPPLSADDTKPASRVGFFSKLTARFGRRV 688
            ||||.|. .|...|    ::..||.:...:|.:.:  |:|||::..|||
  Rat   581 GGSGGGVQNGPPASPTLAHEAAPLPSGRPRPTTNL--FTKLTSKLTRRV 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	Protein Kinases, catalytic domain	98..349	CDD:473864	184/250 (74%)
		UBA_MARK_Par1	370..408	CDD:270522	9/37 (24%)
Mark4	NP_001178000.1	STKc_MARK	58..310	CDD:270974	184/251 (73%)
		UBA_MARK3_4	328..370	CDD:270590	11/41 (27%)
		MARK4_C	654..752	CDD:213382