Protein Alignment KP78a and Gm7356

DIOPT Version :10

• Sequence 1: NP_650066.1
• Gene: KP78a / 41362
• FlyBaseID: FBgn0026064
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_001365198.1
• Gene: Gm7356 / 664821
• MGIID: 3646178
• Length: 549
• Species: Mus musculus
• Alignment Length: 610
• Identity: 173/610 - (28%)
• Similarity: 287/610 - (47%)
• Gaps: 102/610 - (16%)

  Fly    18 SEKTAMTAANKENDPDS-HFTGTIVTTGATAQPATPTTSNATALPATPTVAAGQDLGDGACSSKN 81
            ||:|:..:.:..:..|: :::|     |.|:....|........|.:|.            .|..
Mouse    13 SERTSSGSRSSCSIQDTWNYSG-----GTTSSDKMPAHIEEELPPPSPQ------------PSNP 60

  Fly    82 TDSKFQSYVNGNGNGVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREV 146
            .|.:..|.        ||:::|||.|.:|||.||.|..||..||:||:.|   |....|...:|.
Mouse    61 EDRELYSQ--------YKVVRTLGHGTYAKVLLAQHRLTGTPVAVKVLLK---NKPCFQPAMKEA 114

  Fly   147 KIMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYC 211
            .|||.:.|||||.|.||||::...||:||.....||::::..:|.:.|.:||.||.|::||:.||
Mouse   115 NIMKKIKHPNIVSLLQVIETKTRGYLIMELVEGQELYEYIKNSGHIEEDEARQIFLQILSAVGYC 179

  Fly   212 HSKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEV 276
            |...:||||||.:|:::|...:|||.|||......|...|...||:..:.|||||:.:.|.|.:.
Mouse   180 HGSGIVHRDLKPDNIMIDSKGSIKIIDFGLSTQVKPGQLLHEHCGAYAFGAPELFLWKSYDGTKS 244

  Fly   277 DAWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLS 341
            |.|:|||:||.:|.|::|||...:.||:.::|.|.|..|..:|.:.::|:...:.:||..|.:::
Mouse   245 DLWALGVILYYMVVGNVPFDSFIIPELQMQILAGVYPAPCGVSNELKDLLSLLMTVNPKYRPTVT 309

  Fly   342 AVMSDKWI--------NLGHDESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFD 398
            .||...|:        |: |:|...:||         |....|.:..:|.:.:|:.:|:..:.|:
Mouse   310 EVMKHPWLKGYCKGLTNI-HEEPVPVRP---------DPDIVDAMQYIGFQAKDIRESLSKEKFN 364

  Fly   399 DIYCTYMLLGVAKPRSSNRSTKPEAIPTVDLTTPAVSSPLPNITTPTVTIAHVTLALDKNPPIHS 463
            ::...|.||   :.::..|..:....|||.    .|.:|.|::.....:...:.         .|
Mouse   365 EMSAAYYLL---EEQALQREVRSTQAPTVS----QVKAPFPSMDAGATSCLKIK---------RS 413

  Fly   464 SSASGRPIAPRLANAPNTPTSTPPTGPPAKPTRRTPARTPARKATNHTSGQG---RPEPSSLPHT 525
            .||   ||..| :..|::....|..|...:           ::|...::|.|   ||...    |
Mouse   414 GSA---PILGR-SVWPSSIGQVPAYGQKVR-----------QRAGRRSTGHGLVFRPNQM----T 459

  Fly   526 P-QSKRASANMDVKPTLLS----AQRQLAQ--TQKLANTPPRFQYPVAQTPNQAQGSSRRPTTLY 583
            | |.:.....|.| |.:||    ::..:::  .:.|:|:.|....|:     :::|..|......
Mouse   460 PTQDQHHIRAMSV-PCMLSTSSISEESVSEKREENLSNSAPAEDKPI-----RSRGWRRGIMRWT 518

  Fly   584 EKAEPAVTPL--LVP--KSPAMGAR 604
            .:...|:..|  .:|  |:|.:|.|
Mouse   519 RRVGNAIRTLCCCIPSRKTPRLGQR 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	Protein Kinases, catalytic domain	98..349	CDD:473864	103/250 (41%)
		UBA_MARK_Par1	370..408	CDD:270522	8/37 (22%)
Gm7356	NP_001365198.1	STKc_AMPK-like	68..316	CDD:270905	103/258 (40%)
		UBA_MARK_Par1	336..375	CDD:270522	10/50 (20%)