DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and Gm7168

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_006524826.1	Gene:	Gm7168 / 635895	MGIID:	3643198	Length:	549	Species:	Mus musculus

Alignment Length:	531	Identity:	157/531 - (29%)
Similarity:	256/531 - (48%)	Gaps:	71/531 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SEKTAMTAANKENDPDS-HFTGTIVTTGATAQPATPTTSNATALPATPTVAAGQDLGDGACSSKN 81
            ||:|:..:.:..:..|: :::|     |.|:....|........|.:|..:..:|
Mouse    13 SERTSSGSRSSCSIQDTWNYSG-----GTTSSDKMPAHIEEELPPPSPQPSNPED---------- 62

  Fly    82 TDSKFQSYVNGNGNGVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREV 146
                      |.....||:::|||.|.:|||.||.|..||..||:||:.|   |....|...:|.
Mouse    63 ----------GELYSQYKVVRTLGHGTYAKVLLAKHWLTGTPVAVKVLLK---NKPCFQPAMKEA 114

  Fly   147 KIMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYC 211
            .|||.:.|||||.|.||.|::...||:||.....||::::..:|.:.|.:||.||.|::||:.||
Mouse   115 NIMKKIKHPNIVSLLQVFETKTRGYLIMELVEGQELYEYIKSSGHIEEDEARQIFLQILSAVSYC 179

  Fly   212 HSKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEV 276
            |...:||||||.:|:::|...:|||.|||......|...|:..||:..:.|||||:.:.|.|.:.
Mouse   180 HGLGIVHRDLKPDNIMIDDKGSIKIIDFGLSTQVKPGDLLDEHCGAYAFGAPELFLWKSYDGTKS 244

  Fly   277 DAWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLS 341
            |.|:|||:||.:|.|.:|||...:.||:.::|.|.|..|..:|.:.::|:...:.:||..|.:::
Mouse   245 DLWALGVILYYMVVGKVPFDSYIIPELQRQILAGVYPAPCGVSNELKDLLSLLMTVNPKYRPTVT 309

  Fly   342 AVMSDKWINLGHDESDRLRPFREKPMELQ-DAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYM 405
            .||...|:. ||.:.  |....|:|:.:: |....|.:..:|.:.:|:.:|:..:.|:::...|.
Mouse   310 EVMKHPWLR-GHCKG--LTNIHEEPVPVRPDPDIVDAMQYIGFQAKDIRESLTKEKFNEMSAAYY 371

  Fly   406 LLGVAKPRSSNRSTKPEAIPTVDLTTPAVSSPLPNITTPTVTIAHVTLALDKNPPIHSSSAS--G 468
            ||   :.::..|..:....|||.    .|.:|.|::.....:...:.         .|.|||  |
Mouse   372 LL---EEQALQREVRSTQAPTVS----QVKAPFPSMDAGEASCLKIK---------RSGSASILG 420

  Fly   469 RPIAPRLANAPNTPTSTPPTGPPAKPTRRTPARTPARKATNHTSGQGRP-EPSSLPHTPQSKRAS 532
            |.:                 .||:........:...::|...:||.|.. ||:.:..|.......
Mouse   421 RSV-----------------WPPSIDQEPAYVQKVRQRAGRRSSGHGLLFEPNQMTPTQDQHHIR 468

  Fly   533 ANMDVKPTLLS 543
            | |.| |.:||
Mouse   469 A-MSV-PCMLS 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	102/250 (41%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	102/250 (41%)
Gm7168	XP_006524826.1	STKc_AMPK-like	68..316	CDD:270905	102/250 (41%)
Gm7168	XP_006524826.1	UBA_MARK_Par1	336..375	CDD:270522	9/41 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810