DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and Mark2

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_006230941.1	Gene:	Mark2 / 60328	RGDID:	708483	Length:	841	Species:	Rattus norvegicus

Alignment Length:	695	Identity:	297/695 - (42%)
Similarity:	398/695 - (57%)	Gaps:	115/695 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 TSNATALPA-------TPTVAAGQDLG--DGACSSKN---------TDSKFQSYVNGNGNGVYKI 100
            :|..|.||.       .||      ||  |...|||:         |.:..|.::     |.|::
  Rat     2 SSARTPLPTLNERDTEQPT------LGHLDSKPSSKSNMLRGRNSATSADEQPHI-----GNYRL 55

  Fly   101 IKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKLLNHPNIVRLFQVIE 165
            :||:|||||||||||.|:.||:|||:|:|||||||:|:.|||:|||:|||:|||||||:||:|||
  Rat    56 LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120

  Fly   166 SERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFVVHRDLKAENLLLDQ 230
            :|:||||||||||.||:||:||.:|||:|::||..|||:|||:||||.||:|||||||||||||.
  Rat   121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDA 185

  Fly   231 HMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSLGVVLYTLVSGSLPF 295
            .||||||||||.|.|....:|:||||||||||||||.|:||.|||||.|||||:|||||||||||
  Rat   186 DMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 250

  Fly   296 DGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSDKWINLGHDESDRLR 360
            ||..||||||||||||||:|:|:|.|||||::|||:|||:||.:|..:|.|:|:|:|| |.|.|:
  Rat   251 DGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGH-EDDELK 314

  Fly   361 PFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLLGVAKPRSSNRSTKPEAIP 425
            |:.|...:.:|..|.:|::|||:.|.:::.|:.||.::::..||:|||.........:...:..|
  Rat   315 PYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRP 379

  Fly   426 TVDLTTPAVSSPLPNITTPTVTIAH-VTLALDKNPPIHSSSASGRPIAP------RLANAPNTPT 483
            :.|||..:..||           :| |..::..||....||....|..|      :...:.|...
  Rat   380 SADLTNSSAPSP-----------SHKVQRSVSANPKQRRSSDQAVPAIPTSNSYSKKTQSNNAEN 433

  Fly   484 STP--PTGPPAKPTRRTPARTPA----RKATNHTSGQGRPEPSSLPHT--------PQSKRASAN 534
            ..|  .||..|..|.:.|| :|.    ||.|..|     |..:|:..|        |...|||..
  Rat   434 KRPEEETGRKASSTAKVPA-SPLPGLDRKKTTPT-----PSTNSVLSTSTNRSRNSPLLDRASLG 492

  Fly   535 MDVKPTLLSAQRQLAQTQKLANT-----------PPRFQYPVAQT--PNQAQGSSRRPT-TLYEK 585
               :.::.:.:..|......|:|           |.:.|..::.:  ||:|.|..  || :..|.
  Rat   493 ---QASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLP--PTESNCEV 552

  Fly   586 AEPAVTPLLVPKSPAMGARLLERIPGGGAVEKTSDKPFTRQNVARATFHFGQARSGKRGGGSGNG 650
            ..|:..|..||.:......:..   ..||.::|:   |.|...:|:|||.||.|..:
  Rat   553 PRPSTAPQRVPVASPSAHNISS---SSGAPDRTN---FPRGVSSRSTFHAGQLRQVR-------- 603

  Fly   651 AGGEEDSYQTPPLSADDTKPA----SRVG----FFSKLTARFGRR 687
                  ..|..|.......|:    .|.|    .|||.|::|.||
  Rat   604 ------DQQNLPFGVTPASPSGHSQGRRGASGSIFSKFTSKFVRR 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	184/250 (74%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	184/250 (74%)
Mark2	XP_006230941.1	STKc_MARK	52..304	CDD:270974	184/251 (73%)
		S_TKc	53..304	CDD:214567	184/250 (74%)
		UBA_MARK2	322..363	CDD:270589	14/40 (35%)
		MARK2_C	742..840	CDD:213386
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45341
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24346
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910