DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and mark4b

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_005157655.1	Gene:	mark4b / 571279	ZFINID:	ZDB-GENE-100330-2	Length:	796	Species:	Danio rerio

Alignment Length:	719	Identity:	285/719 - (39%)
Similarity:	394/719 - (54%)	Gaps:	137/719 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SEKTAMTAANKENDPDSHFTGTIVTTGATAQPATPTTSNATALPATPTVAAGQDLGDGACSSKNT 82
            |.:.|:...|..| .|.|.|    .:.:.::..:..:|.:.......::|        :||.:
Zfish     2 SSRAALQPGNDRN-ADHHAT----LSASRSEKGSGWSSRSLGARCRNSIA--------SCSDE-- 51

  Fly    83 DSKFQSYVNGNGNGVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVK 147
                |.::     |.|:::||:|||||||||||.|:.||||||||:|||||||.::.|||:|||:
Zfish    52 ----QPHI-----GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVR 107

  Fly   148 IMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCH 212
            |||.|||||||:||:|||:|:||||||||||.||:||:||.:|||:|::||..|||:|||:.|||
Zfish   108 IMKGLNHPNIVQLFEVIETEKTLYLVMEYASGGEVFDYLVSHGRMKEKEARGKFRQIVSAVHYCH 172

  Fly   213 SKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVD 277
            .|.:|||||||||||||...|||||||||.|.|...::|:||||||||||||||.|:||.|||||
Zfish   173 LKNIVHRDLKAENLLLDADSNIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVD 237

  Fly   278 AWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSA 342
            .|||||:|||||||||||||..||||||||||||||||:|:|.|||.::|:||||||.||.:|..
Zfish   238 IWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRVPFYMSTDCEGILRRFLVLNPTKRCTLEQ 302

  Fly   343 VMSDKWINLGHDESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLL 407
            :|.|||:|:|: |:|.|:|:.|...:..|.:|.|:::.||:.|.:::.::..|.:::|:.||:||
Zfish   303 IMKDKWMNVGY-ENDELKPYIEPVEDYNDTSRVDVMVGMGYSRDEIKDALTTQKYNEIFATYLLL 366

  Fly   408 GVAKPRSSNRSTKPEAIPTVDLTTPAVSSPLPNITTPTVTIAHVTLALDKNPPIHSSSASGRPIA 472
            |    |.:....:..:..::.|.....|:              :|....|    |||::|....:
Zfish   367 G----RKNEDGMESRSSSSLSLARVRPSA--------------ITNGTSK----HSSTSSSSSTS 409

  Fly   473 PRLANAPNTPTST-----------PPTGPPAKPTRRTPARTPARKATNHTSGQGRPEPSSLPHTP 526
            ......|....||           .|:.|.|.| :|:|..|          |:|..:...||...
Zfish   410 ASSHTKPQRSASTYHRQRRHSDFCGPSVPVAHP-KRSPTST----------GEGDLKEERLPSRK 463

  Fly   527 QSKRASANMDVKPTLLSAQRQLAQTQKLANTPPRFQYP-----VAQTPNQ--AQGSSRRPT---- 580
            .|.....:..:.|:        :.....||.|.:.:.|     :..|.|.  |...:||.|
Zfish   464 TSSSVVGSRSIPPS--------SPMVSTANNPNKSEIPDRRKDINATTNNIPASAMTRRNTYVCT 520

  Fly   581 --------TLYE--KAEPAVTPLLVPKSPAMGARLLERIPGGGAVEKTSDK--PFTRQNVARATF 633
                    :|.:  |...:::..|.|.||:     ...|.|.||...||.:  ..||.:..|:||
Zfish   521 DRTGTDRHSLLQNGKENSSLSHRLPPASPS-----THSISGAGASSSTSSERSRLTRGSTIRSTF 580

  Fly   634 HFGQARSGKRGGGSGNGAGGEEDSYQTPPLSADDTKPA--------------SRVGFFSKLTARF 684
            |.||.|..:                  ||..|..|.|.              :....|:|||::.
Zfish   581 HGGQLREHR------------------PPTHAPPTSPTLSHEASPLPHSRSRATTNLFTKLTSKL 627

  Fly   685 GRRV 688
            .|||
Zfish   628 TRRV 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	183/250 (73%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	183/250 (73%)
mark4b	XP_005157655.1	STKc_MARK	57..309	CDD:270974	183/251 (73%)
		S_TKc	58..309	CDD:214567	183/250 (73%)
		UBA_like_SF	327..369	CDD:304366	13/45 (29%)
		MARK4_C	699..796	CDD:213382
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910