DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and mark4a

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_005165424.1	Gene:	mark4a / 569346	ZFINID:	ZDB-GENE-060531-156	Length:	762	Species:	Danio rerio

Alignment Length:	732	Identity:	297/732 - (40%)
Similarity:	398/732 - (54%)	Gaps:	149/732 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SEKTAMTAANKENDPDSHFTGTIVTTGATAQPATPTTSNATALPATPTVAAGQDLGDGACSSKNT 82
            |.::|:|:|| :...|.|.:    ...:.::..|..:|              :.|| ..|  :|:
Zfish     2 SSRSALTSAN-DRSTDHHAS----LVASRSEKGTNVSS--------------RSLG-ARC--RNS 44

  Fly    83 DSKFQSYVNGNGNGVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVK 147
            .:.:...:...||  |:::||:|||||||||||.|:.||:|||||:|||||||.::.|||:|||:
Zfish    45 MASYSDELPHIGN--YRLLKTIGKGNFAKVKLARHILTGKEVAIKIIDKTQLNPTSLQKLFREVR 107

  Fly   148 IMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCH 212
            |||.|:|||||:||:|||:|:||||||||||.||:||:||.:|||:|.:||..|||:|||:.|||
Zfish   108 IMKTLHHPNIVQLFEVIETEKTLYLVMEYASGGEVFDYLVSHGRMKEIEARAKFRQIVSAVHYCH 172

  Fly   213 SKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVD 277
            .|.:|||||||||||||...|||||||||.|.|....:|:||||||||||||||.|:||.|||||
Zfish   173 QKNIVHRDLKAENLLLDADSNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVD 237

  Fly   278 AWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSA 342
            .|||||:|||||||||||||..||||||||||||||||:|:|.|||.::|:||||||:||.:|..
Zfish   238 IWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRVPFYMSTDCEGILRRFLVLNPSKRCTLEQ 302

  Fly   343 VMSDKWINLGHDESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLL 407
            ||.|||:|.||| .|.|:|..|...:..||.|.::::.||....:::.|:..|.::::..||:||
Zfish   303 VMKDKWMNAGHD-GDELKPHIEPTEDYSDANRIEIMVGMGFTTEEIKDSLLNQKYNEVTATYLLL 366

  Fly   408 GV-----AKPRSSNRSTKPEAIPTVDLTTPAVSSPLPNITTPTVTIAHVTLALDKNPPIHSSSAS 467
            |:     |:.|.|...|.|...|          ||:.|.|             :|:....|||:|
Zfish   367 GLKTEDGAESRVSGSMTLPRVRP----------SPITNGT-------------NKHSSSSSSSSS 408

  Fly   468 GRPIAPRLAN----------------APNTPTSTPPTGPPAKPTRR-TPARTPARKATNHTSGQG 515
            ......|.|:                .|:.|...|...|.:...|. ..:|.|.|||:....|.
Zfish   409 SHSKTQRSASTYHRQRRHSDFFCSAGGPSMPVMHPKRSPTSGGDRELRESRMPPRKASCSVMGS- 472

  Fly   516 RPEPSSLPHTPQSKRASANMDVKPTLLSAQRQLAQTQKLANTPPRFQYP-----VAQTPNQAQGS 575
                .:||  |.|...|.                     ||.|.:.:.|     :..|.|...||
Zfish   473 ----RTLP--PSSPMVST---------------------ANNPNKAEIPDRRKEMTATTNNIPGS 510

  Fly   576 --SRRPT------------TLYE--KAEPAVTPLLVPKSPAMGARLLERIPGGGAVEKTSDKP-- 622
              :||.|            :|.:  |...:::..|.|.||:..:     |.|.||...:|...
Zfish   511 TMTRRNTYVCTDRSSTDRHSLLQNGKDNSSLSHRLPPTSPSTLS-----IVGAGASSSSSSGERC 570

  Fly   623 -FTRQNVARATFHFGQARSGKRGGGSGNGAGGEEDSYQTPP----LSAD------DTKPASRVGF 676
             .||.:..|:|||.||.|.            ....:|..||    ||.|      :.:..:....
Zfish   571 RLTRGSTIRSTFHGGQLRD------------RVPPTYGPPPTSPTLSHDAGALPANARSRATSNL 623

  Fly   677 FSKLTARFGRRVIHLNE 693
            |||||::..|||.:.:|
Zfish   624 FSKLTSKLTRRVSNESE 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	182/250 (73%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	182/250 (73%)
mark4a	XP_005165424.1	STKc_MARK	57..309	CDD:270974	183/253 (72%)
		UBA_MARK3_4	327..369	CDD:270590	12/41 (29%)
		MARK4_C	662..762	CDD:213382
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910