DRSC/TRiP Functional Genomics Resources

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Protein Alignment KP78a and MARK1

DIOPT Version :9

Sequence 1:NP_650066.1 Gene:KP78a / 41362 FlyBaseID:FBgn0026064 Length:705 Species:Drosophila melanogaster
Sequence 2:NP_001273053.1 Gene:MARK1 / 4139 HGNCID:6896 Length:796 Species:Homo sapiens


Alignment Length:731 Identity:287/731 - (39%)
Similarity:396/731 - (54%) Gaps:129/731 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 SEKTAMTAANKENDPDSHFTGTIVTTGATAQPATPTTSNATA-LPATPTVAAGQDLGDGACSSKN 81
            |.:|.:...| |.|.::|.:    ..|.|.....||.|::.. :|              .|.:..
Human     2 SARTPLPTVN-ERDTENHTS----VDGYTEPHIQPTKSSSRQNIP--------------RCRNSI 47

  Fly    82 TDSKFQSYVNGNGNGVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREV 146
            |.:..:....||    |::.||:|||||||||||.||.||||||:|:|||||||.::.|||:|||
Human    48 TSATDEQPHIGN----YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREV 108

  Fly   147 KIMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYC 211
            :|||:|||||||:||:|||:|:||||||||||.||:||:||.:|||:|::||..|||:|||:|||
Human   109 RIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 173

  Fly   212 HSKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEV 276
            |.|::|||||||||||||..||||||||||.|.|....:|:||||||||||||||.|:||.||||
Human   174 HQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEV 238

  Fly   277 DAWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLS 341
            |.|||||:|||||||||||||..||||||||||||||:|:|:|.|||||::|.|||||.||.||.
Human   239 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLE 303

  Fly   342 AVMSDKWINLGHDESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYML 406
            .:|.|:|:|:||:| :.|:|:.|...:..|..|.|::::||..|.::..::..|.:|::..||:|
Human   304 QIMKDRWMNVGHEE-EELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMATYIL 367

  Fly   407 LGVAKPR--------SSNRSTKPEAIPTVDLTTPAVSSPL----------------------PNI 441
            ||...|.        |.|...:..  |:.||....:.||.                      |:|
Human   368 LGRKPPEFEGGESLSSGNLCQRSR--PSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGPSI 430

  Fly   442 TTPTVTIAHVTLALDKNPPIHSSSAS---------GRPIAPRLANAPNTPTSTPPTGPPAKPTRR 497
             .|.|:..       |.|..:|..:.         .|.:......:.:..|::|..||..|.:..
Human   431 -PPAVSYT-------KRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGPERKKSST 487

  Fly   498 TPAR------TPAR-------KATNHTSGQGRPEPSSLPHTPQSKRASANMDVKPTLLSAQRQLA 549
            .|:.      :.||       :.|:........:.|||.....|..:||...|...:.||:.:..
Human   488 IPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSVASAVPSARPRHQ 552

  Fly   550 QTQKLANTPPRFQYPVAQTPNQAQGSSRRPTTLYEKAEPAVTPLLVPKSPAMGARLLERIPGGGA 614
            ::...:..|.:...|..:..::|.    ||.:..::. ||.:|.....|.|              
Human   553 KSMSTSGHPIKVTLPTIKDGSEAY----RPGSTTQRV-PAASPSAHSISTA-------------- 598

  Fly   615 VEKTSDKP-FTRQNVARATFHFGQARSGKRGGGSGNGAGGEEDSYQTPPLSAD-------DTKPA 671
               |.|:. |.|.:.:|:|||..|.|..:            ..:|..||.|..       ..:..
Human   599 ---TPDRTRFPRGSSSRSTFHGEQLRERR------------SVAYNGPPASPSHETGAFAHARRG 648

  Fly   672 SRVGFFSKLTARFGRR 687
            :..|..||:|::|.||
Human   649 TSTGIISKITSKFVRR 664

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KP78aNP_650066.1 PKc_like 98..349 CDD:304357 185/250 (74%)
S_TKc 98..349 CDD:214567 185/250 (74%)
MARK1NP_001273053.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 11/42 (26%)
STKc_MARK 59..311 CDD:270974 186/255 (73%)
S_TKc 60..311 CDD:214567 185/250 (74%)
UBA_MARK1 331..371 CDD:270588 13/39 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 377..495 21/127 (17%)
MARK1-3_C 697..794 CDD:213381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0586
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24346
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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