Protein Alignment KP78a and Brsk1

DIOPT Version :10

• Sequence 1: NP_650066.1
• Gene: KP78a / 41362
• FlyBaseID: FBgn0026064
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: XP_017177814.1
• Gene: Brsk1 / 381979
• MGIID: 2685946
• Length: 806
• Species: Mus musculus
• Alignment Length: 765
• Identity: 225/765 - (29%)
• Similarity: 326/765 - (42%)
• Gaps: 219/765 - (28%)

  Fly    96 GVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKLLNHPNIVRL 160
            |.|::.||||||....|||.:|..||::||:|::::.:|:.|...|:.||:.|:||:.||::::|
Mouse    32 GPYRLEKTLGKGQTGLVKLGVHCITGQKVAVKIVNREKLSESVLMKVEREIAILKLIEHPHVLKL 96

  Fly   161 FQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFVVHRDLKAEN 225
            ..|.|:::.||||:|:.|.|||||:|||.||:..::||..|||:|||:.:|||..:.|||||.||
Mouse    97 HDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPEN 161

  Fly   226 LLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSLGVVLYTLVS 290
            ||||:..||:|||||..:....::.|||.||||.||.||:..|.||.|...|.||.||:|:.|:.
Mouse   162 LLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLV 226

  Fly   291 GSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSDKWINLGHDE 355
            |:||||...|::|.|:|.||.:.:|::|..||::|:|..:.:.|.||.||..:....|...|..|
Mouse   227 GALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHE 291

  Fly   356 SDR-LRP-------FREKPM--ELQDAARFDLLMSMG-----------HKR-RDVEQSVKGQLFD 398
            .|. |.|       .|..|.  ||..    |:|.||.           |:. |..|::.:..::
Mouse   292 PDPCLEPAPGRRVAMRSLPSNGELDP----DVLESMASLGCFRDRERLHRELRSEEENQEKMIY- 351

  Fly   399 DIYCTYMLL------------------GVAKPR--------SSNRSTKPE--------------- 422
                 |:||                  .|..||        |.:...:||
Mouse   352 -----YLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGSG 411

  Fly   423 --AIPT----------------VDLTTPAVSSPLPNITTPTVTIAHVTLALD------------- 456
              .:||                ...:|...||||.:..:|..:.:....|.|
Mouse   412 GSPVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQ 476

  Fly   457 -------------KNPP---IHSSSASGRPIAPRLANAPNTPTSTPPTGPPAKPTRRTPARTP-- 503
                         :.||   ..|:...|.|.:||  ::..||..:|...|.|.|| .||..||
Mouse   477 TLPSRGPRGGGAGEQPPPPSARSTPLPGPPGSPR--SSGGTPLHSPLHTPRASPT-GTPGTTPPP 538

  Fly   504 ------------ARKATNHTSGQGRP-------------EPSSLPHTPQS-----KR-------- 530
                        :|..:...|..|.|             |.|||  ||:|     ||
Mouse   539 SPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSL--TPESSPELAKRSWFGNFIS 601

  Fly   531 ----------------ASANMDVKPTLLS----AQRQLAQTQ-----KLANTPPRFQYPV----- 565
                            :|...|:....||    :...|:||.     |.:..|..||.||
Mouse   602 LDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKPVRFQVD 666

  Fly   566 AQTPNQAQGSSRRPTT----LYEKAEPAVTPLLVPKSPAMGARLLERIPGGGAVEKTSDKPFTRQ 626
            ..:....:.|.||..:    :|     :||..|:........|::|.|.  ..:..|.|:|..
Mouse   667 ISSSEGPEPSPRRDGSSGGGIY-----SVTFTLISGPSRRFKRVVETIQ--AQLLSTHDQPSV-- 722

  Fly   627 NVARATFHFGQARSGKRGGGSGNGAGGEEDSYQTPPLSAD-DTKPASRVG 675
                      ||.:.::.|.....||....|.|.||..:| |...:.|.|
Mouse   723 ----------QALADEKNGAQTRPAGTPPRSLQPPPGRSDPDLSSSPRRG 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	Protein Kinases, catalytic domain	98..349	CDD:473864	118/250 (47%)
		UBA_MARK_Par1	370..408	CDD:270522	10/67 (15%)
Brsk1	XP_017177814.1	STKc_BRSK1_2	32..285	CDD:270983	119/252 (47%)
		UBA_BRSK	314..367	CDD:270525	12/62 (19%)