Protein Alignment KP78a and Gm14147

DIOPT Version :10

• Sequence 1: NP_650066.1
• Gene: KP78a / 41362
• FlyBaseID: FBgn0026064
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: XP_355352.1
• Gene: Gm14147 / 381390
• MGIID: 3651555
• Length: 640
• Species: Mus musculus
• Alignment Length: 642
• Identity: 176/642 - (27%)
• Similarity: 295/642 - (45%)
• Gaps: 133/642 - (20%)

  Fly    98 YKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKLLNHPNIVRLFQ 162
            |:|:.|||:|.|..||||.|:.|..:||||::.:.:.|...:.    |::|||.|:||:|::|..
Mouse    24 YEILTTLGQGTFGDVKLANHLVTQTKVAIKILPQNRKNPLVQP----EIEIMKSLDHPHIIKLLH 84

  Fly   163 VIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFVVHRDLKAENLL 227
            :|::.|.:::|:|:|..|||.:.:.:.|.:.|.:...:|:|||.|:||||.|.:||||||.||:|
Mouse    85 IIDTTRNIFIVLEHAVGGELMNRIEEFGYLAEVECHRLFKQLVYALQYCHEKGIVHRDLKPENIL 149

  Fly   228 LDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSLGVVLYTLVSGS 292
            ||...|:|:.|||.|.......:|.||||:.||.|||||..|.|.|...|.||||||||.:.:|.
Mouse   150 LDHRGNVKLTDFGLGTKIIMGQKLVTFCGTLPYCAPELFEDRGYDGRATDVWSLGVVLYFMATGC 214

  Fly   293 LPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSDKWINLGHDESD 357
            |||:|.:.:.::::::.|||...:.:|.:...::.|.|.:||.:|.::..:...||
Mouse   215 LPFNGYSYEAIKQKIIAGKYPRSFSLSPELWEVIAKLLTVNPGERPTVHDIARFKW--------- 270

  Fly   358 RLRPFRE-KPMEL-------QDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLLGVAKPRS 414
             |:|..| .|..|       .|.:...|:..||:...::.:|::.:.||.:..||::|   |.:|
Mouse   271 -LKPDNEASPASLGENIESHPDPSIMVLMGVMGYNPGEIRESLREKKFDQVMATYLML---KQQS 331

  Fly   415 S--NRST-KPEAIPTVDLTTPAVSSPLPNITTPTVTIAHVTLALDKNPPIHSSSASGRPIAPRLA 476
            :  |::| ||:         |.:...:...|.||:. ....:....:.|.||:           .
Mouse   332 AWENKTTKKPD---------PRLCDRMLRSTEPTIK-NQTAVRRASSVPTHST-----------F 375

  Fly   477 NAPNTPTSTPPTGPPAKPTRRTPARTPARKATNHTSGQGRPEPSSLPHTPQSKRASANMDVKPTL 541
            :.||...|.    ...|.|..:.:..|.|...|.   :..|..|..|...|......:
Mouse   376 SLPNESESL----EKGKRTTMSHSMPPTRNCFNE---ETTPLHSICPQLVQKAHYRRS------- 426

  Fly   542 LSAQRQLAQTQKLANTPPRFQYP---------------VAQTPNQAQGSSRRPTTLYEKAEP--- 588
            :..:.:::.|.:.::|....::|               ...|.::::|||:..::.:...|.
Mouse   427 IWGETEISDTSEESSTGESLEHPSLKIHTLQTSMGVSKAGSTYSKSKGSSQCVSSHHTSVEEDQC 491

  Fly   589 -------AVTPLLVPKSP---AMGARLLERIPGGGAVE----KTSDKPFTRQNVARATFHFGQAR 639
                   .:.|.|.|.||   .||.  |..:...|:::    :.:..||:|
Mouse   492 EGTNISREINPPLSPVSPQENLMGQ--LHIVTTAGSMDIMNTQVTSPPFSR-------------- 540

  Fly   640 SGKRGGGSGNGAGGEEDSYQTPPLSADDTKPASRVGFFSKLTAR--------FGRRV 688
              |...|.|            |.:...:::|:|.......|..|        |.|||
Mouse   541 --KEAKGEG------------PAIQQRESRPSSPNTLQGHLHGRHQTAPQAPFQRRV 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	Protein Kinases, catalytic domain	98..349	CDD:473864	103/250 (41%)
		UBA_MARK_Par1	370..408	CDD:270522	9/37 (24%)
Gm14147	XP_355352.1	STKc_AMPK-like	23..270	CDD:270905	102/249 (41%)
		UBA_MARK_Par1	290..328	CDD:270522	10/40 (25%)