DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and mark3a

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_021336197.1	Gene:	mark3a / 334300	ZFINID:	ZDB-GENE-030131-6232	Length:	746	Species:	Danio rerio

Alignment Length:	683	Identity:	283/683 - (41%)
Similarity:	379/683 - (55%)	Gaps:	120/683 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 ATAQPATPTTSNATALPATPTVAAGQDLGDGACSSKNTDSKFQSYVNGNG-------NGVYKIIK 102
            :|.:...||.:...|...|..   |.  |....:|::..|..::..:|:|       .|.|:::|
Zfish     2 STTRAPLPTVNERKAENHTTN---GH--GRSEVTSRSVRSSGRNRNSGSGLDDVHPVIGNYRLLK 61

  Fly   103 TLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKLLNHPNIVRLFQVIESE 167
            |:|||||||||||.|:.||.|||||:|||||||.::.|||.|||.|||.|||||||:||:|||:|
Zfish    62 TIGKGNFAKVKLARHILTGSEVAIKMIDKTQLNPTSLQKLSREVTIMKNLNHPNIVKLFEVIETE 126

  Fly   168 RTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFVVHRDLKAENLLLDQHM 232
            :||:|||||||.||:||:||.:|||:|::||..|||:|||:||||.|.:|||||||||||||..|
Zfish   127 KTLFLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDGDM 191

  Fly   233 NIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSLGVVLYTLVSGSLPFDG 297
            |||||||||.|.|...::|:||||||||||||||.|:||.|||||.|||||:|||||||||||||
Zfish   192 NIKIADFGFSNEFMVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG 256

  Fly   298 GTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSDKWINLGHDESDRLRPF 362
            ..||||||||||||||:|:|:|.|||||:::|||||||||.:|..:|.::|||.|. |.|.|:||
Zfish   257 QNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGTLEQIMKERWINSGF-EDDELKPF 320

  Fly   363 REKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLLG-----------------VA 410
            .|...::.|..|.|:::.||..:..:.:|:....:|::...|:|||                 ||
Zfish   321 TEPDADISDQKRIDVIVGMGFSKEKIHESLFKMNYDEVTAIYLLLGRKTHEEVSDSSSNSNLSVA 385

  Fly   411 K--PRSSNRSTKPEAIPTVDLTTPAVSSPLPNITTPTVTIAHVTLALDKN-PPIHSSS---ASGR 469
            |  |.|...|..|..:......:.:.|......:.....:|:..|:..|. .|:.:.|   ..|.
Zfish   386 KTRPSSEMNSQSPSHLKVQRSISSSESRKSRRHSEQVGVVANNALSNSKRVVPVTADSEVKQEGG 450

  Fly   470 PIAPRLANAPNTPTSTPPTGPPAKPTRRTPART--PARK-----ATNHTSGQGRPEPSSLPHTPQ 527
            .||.:|      |..:||:  |.......|.:|  |.||     .:|:.||.|
Zfish   451 VIARKL------PNHSPPS--PLLGNANNPNKTEIPDRKKGNSITSNNISGSG------------ 495

  Fly   528 SKRASANMDVKPTLLSAQRQLAQTQKLANTPPRFQYPVAQTPNQAQGSSRRPTTLYEKAEPAVTP 592
                  :|..:.|.:..:|.  .|.:|:..|...:..|:.:|     |||.|.........:|||
Zfish   496 ------SMSRRNTYVCTERN--NTDRLSVIPNGKENSVSLSP-----SSRDPGASTHSISTSVTP 547

  Fly   593 LLVPKSPAMGARLLERIPGGGAVEKTSDKPFTRQNVARATFHFGQARSGKRGGGSGNGAGGEEDS 657
                                   :||.   |.|.:.:|:||| ||.|..:..            :
Zfish   548 -----------------------DKTR---FPRGSASRSTFH-GQVRDRRTA------------T 573

  Fly   658 YQTPPLSADDTKPASRV---GFFSKLTARFGRR 687
            |..||  |...:|.||.   ...:|||::..||
Zfish   574 YNGPP--ASPAQPRSRANANNLLTKLTSKLTRR 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	182/250 (73%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	182/250 (73%)
mark3a	XP_021336197.1	STKc_MARK	56..308	CDD:270974	182/251 (73%)
		UBA_like_SF	326..368	CDD:328731	11/41 (27%)
		MARK1-3_C	647..744	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910