Protein Alignment KP78a and Sik2

DIOPT Version :10

• Sequence 1: NP_650066.1
• Gene: KP78a / 41362
• FlyBaseID: FBgn0026064
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_001414257.1
• Gene: Sik2 / 315649
• RGDID: 1559698
• Length: 932
• Species: Rattus norvegicus
• Alignment Length: 614
• Identity: 220/614 - (35%)
• Similarity: 310/614 - (50%)
• Gaps: 104/614 - (16%)

  Fly    96 GVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKLLNHPNIVRL 160
            |.|.|..||||||||.|||..|..|..|||||:|||:||:....:|:||||:|||:|:||:|::|
  Rat    18 GFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKL 82

  Fly   161 FQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFVVHRDLKAEN 225
            :||:|::..||||.|||..||:||:|..:||:.|.:||..|.|::||:.||||:.||||||||||
  Rat    83 YQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHSRKVVHRDLKAEN 147

  Fly   226 LLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSLGVVLYTLVS 290
            ||||..||||||||||||.|.....|.|:||||||||||:|.|::|.||::|.||:|||||.||.
  Rat   148 LLLDNSMNIKIADFGFGNFFKTGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVC 212

  Fly   291 GSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSDKWINL---- 351
            |:|||||.||..||:|||.|::|:||::|.|||:|:|:.|||:|:||.|::.:...||:.:
  Rat   213 GALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLSIAQIKEHKWMLIEVPV 277

  Fly   352 --------GHDESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLL- 407
                    ..:....:..|.|:.:.        |:.|:|..::...:|::.:.::.....|.||
  Rat   278 QRPILYPQEQENEPSIGEFNEQVLR--------LMHSLGIDQQKTIESLQNKSYNHFAAIYFLLV 334

  Fly   408 -GVAKPRSS--------NRSTKPEAI--------PTVDLTTPAVSSPLPNITTPTVTIAHVTLAL 455
             .:...|||        .|..:|..|        .||.|  |....| ||:.....|:    |..
  Rat   335 ERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGL--PVTLHP-PNLRLMRSTL----LPQ 392

  Fly   456 DKNPPIHSSSASGRPIAPRLANAPNTPTSTPPTG-------PPAKPTRRTPARTPARKATN---- 509
            ..|....|..||..|  ...|........||...       ||....:...:...:...|:
  Rat   393 ASNVEAFSFPASSCP--AEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSSMMETSIDEG 455

  Fly   510 -HTSGQGRPEPSSLPHTPQSKRASANMDVKPTLLSAQRQLAQTQKLANTPPRFQYPVAQTPN--- 570
             .|.|:...:||......|:.|:...   :.||.....||....:....     :.::.:|:
  Rat   456 LETEGEAEEDPSQAFEAFQATRSGQR---RHTLSEVTNQLVVLPRAGKV-----FSMSDSPSLDS 512

  Fly   571 ----QAQGSSRRPTT------------LYEKAEPAVTPL--LVPKSPAMGARLLERIPGGGAV-- 615
                ...||::|...            |..:..|.:||.  |.|.:|||.|...:|.......
  Rat   513 VDSEYDMGSAQRDLNFPEDSPSLKDIMLANQPSPRMTPFISLRPANPAMQALSSQRREAHNRSPV 577

  Fly   616 -----EKTSDKPFTR---------QNVAR 630
                 .:.||...|:         ||:||
  Rat   578 SFREGRRASDTSLTQGIVAFRQHLQNLAR 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	Protein Kinases, catalytic domain	98..349	CDD:473864	151/250 (60%)
		UBA_MARK_Par1	370..408	CDD:270522	7/39 (18%)
Sik2	NP_001414257.1	None