DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and Sik2

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster

Alignment Length:	807	Identity:	255/807 - (31%)
Similarity:	370/807 - (45%)	Gaps:	207/807 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LSSGKESEKTAMTAANKENDPDSHFTGTIVTTGATAQPATPTTSNATALPATPTVAAGQDLGDGA 76
            |.:|..|.......|.|    |:.....:..:|..:.|....||:|              :|.|.
  Fly    77 LDAGAASPSIDAIVACK----DALLAQKLFASGGGSTPGPSPTSSA--------------VGAGG 123

  Fly    77 CSSKNTDSKFQSYVNGNGNGVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQK 141
            .|.|:. .|.:..:.   .|.|.|.:|:||||||.||||.|..|..|||||:|||:||:.:..||
  Fly   124 ISGKDL-LKLKEPMR---VGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQK 184

  Fly   142 LYREVKIMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVS 206
            :||||:|||.|.||:|::|:||:|::..:|:|.||||:||:||::.|.|||.|..||..|.|::|
  Fly   185 VYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIIS 249

  Fly   207 AIQYCHSKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKY 271
            |::|||.|.:|||||||||||||.:||||||||||.|.|.|...|.|:||||||||||:|.|::|
  Fly   250 AVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQY 314

  Fly   272 AGPEVDAWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAK 336
            .|||:|.||||||||.||.|:|||||.||:.||:|||.|::|:|:::|.:||:|:|:.|||.|.:
  Fly   315 TGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTR 379

  Fly   337 RTSLSAVMSDKWI-------------NLGHDESDRLRPFREKPMELQDAARFDLLMSM----GHK 384
            |.::..:...:|:             |||.:....:.|..            |:|..|    |..
  Fly   380 RYTIDQIKRHRWMCPELLEHVLIAKYNLGAERQTSVEPSE------------DILRIMAEYVGIG 432

  Fly   385 RRDVEQSVKGQLFDDIYCTYMLL-----------------GVAKPRSSNR---STKPEAIPTVDL 429
            ......|:|...:|.:...|:||                 .:|...|::|   |::.:..||..
  Fly   433 SDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQ- 496

  Fly   430 TTPAVSSPLPNITTPTVTIAHVTLALDKNPPIHSSSASGRPI--APRLANAPNTPTSTPPTGP-- 490
                 .|...:.|..|.:|    ||.|:   .|...:..:.:  :.|.|:|..||| .|..||
  Fly   497 -----QSQQQSKTISTSSI----LAKDQ---CHKRLSRHQTVLMSERNAHAGATPT-VPDPGPGY 548

  Fly   491 -----PAK-----------------------------PTRRTP---ARTPARKATNHTSGQ-GRP 517
                 |.:                             |.|.||   |.:||....:.||.: ||.
  Fly   549 YAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLPTAASPAPSNCSSTSSRVGRH 613

  Fly   518 EPSSLPHTPQSKR---ASANMDVKPTLLS---------------------AQRQLAQTQKLANTP 558
            ..||  .:|:|.|   .|.::|..|:|.:                     |.:||.||..
  Fly   614 SLSS--SSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGGPVGAVGVPLASKQLHQTIS----- 671

  Fly   559 PRFQYPVAQTPNQAQGSSRRPTTLYE------KAEPAV---------TPLLVPKSPAMGARLLER 608
               ::.:.|:....:...::.|.:.|      |||.:|         ||......|..|:
  Fly   672 ---EFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVPPPASTTPTSSTAGPESGS----- 728

  Fly   609 IPGGGAVEKTSDKPFTRQNVARATFHFGQARSGKRGG--------------------------GS 647
            .|..|.:...:.|..:..:...:..:.||:...|...                          ||
  Fly   729 APCPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASKLFQTLQESPLPVEQRTKRRVHVGS 793

  Fly   648 GNGAGGEEDSYQTPPLSADDTKPASRV 674
            .||:||:.........|..|::...:|
  Fly   794 TNGSGGDSGQETNDAKSNGDSRSEKKV 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	148/250 (59%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	148/250 (59%)
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	148/251 (59%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	148/250 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810