DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and RGD1560303

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_218667.4	Gene:	RGD1560303 / 292948	RGDID:	1560303	Length:	494	Species:	Rattus norvegicus

Alignment Length:	484	Identity:	161/484 - (33%)
Similarity:	245/484 - (50%)	Gaps:	79/484 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 YKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKLLNHPNIVRLFQ 162
            |.|:|.||:|...:|:|:.|..||..||:|.:.|.:.:.::...   ||:|||:|||.|||.|.|
  Rat    29 YTILKPLGQGGTTEVRLSSHRLTGTPVAVKALVKHERHWASTMS---EVEIMKILNHNNIVSLLQ 90

  Fly   163 VIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFVVHRDLKAENLL 227
            |:|:|:.:|::||.|....|.:.:.|.||::|.:||.||.||:||:.|||.|.::|||||.:|::
  Rat    91 VMETEQNIYIIMEVAQGDSLLNRVQKAGRLKEDEARGIFVQLLSALGYCHGKGIIHRDLKPDNII 155

  Fly   228 LDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSLGVVLYTLVSGS 292
            :|:|.|:||.|||.|..|.|..:|:..||:..:..||||:|..|.||:||.|:|||:||.:|:|.
  Rat   156 VDEHGNVKIIDFGLGAKFLPGQKLKRLCGAFQFIPPELFLGLPYDGPKVDIWALGVLLYFMVTGF 220

  Fly   293 LPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSDKWIN------L 351
            .||.|.||.||.:.||:|:|.:||.:|.|..:::...|.:|..:|.:...:.|..|:.      .
  Rat   221 APFSGTTLSELSKNVLQGRYDIPYNLSKDLRSMISLLLTVNARQRPTAQDLSSHPWLQEWGKTLT 285

  Fly   352 GHDESDRLRPFREKPMELQDAARFDLLMSM---GHKRRDVEQSVKGQLFDDIYCTYMLLGVAKPR 413
            .|...|...|.|            |::::|   |...:|:::|:|.:.||:...||:||.|...:
  Rat   286 FHSNRDTSFPNR------------DIMVAMENIGFHVQDIKESLKHKKFDETMATYLLLRVQACQ 338

  Fly   414 SSNRSTKPEAIPTVDLTTPAVSSPLPNITTPTVTIAHVTLALDKNPPIHSSSASGRPIA------ 472
            :.....:.:      |..|.| :|.|:...|.      |..|   ||...:|.....|.
  Rat   339 NGGNYVQTK------LLNPGV-APFPSAADPD------TFPL---PPRRRASEPSLKIVVASSEQ 387

  Fly   473 PRL-----ANAPNTPTSTPPTGPPAKPTRRTPARTPARKATNHTSGQGRPEPSSLPHTPQSKRAS 532
            .||     .|||..|..||..|           |...|..|:                |...|.:
  Rat   388 QRLRQSGGTNAPVQPKKTPVMG-----------RGYKRCVTD----------------PCILRRN 425

  Fly   533 ANMDVKPTLLSAQRQ-LAQTQKLANTPPR 560
            ..|:|.....||..| |:.:::..:..||
  Rat   426 TGMNVDTISFSASSQTLSDSERSRSLQPR 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	109/250 (44%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	109/250 (44%)
RGD1560303	XP_218667.4	STKc_AMPK-like	28..276	CDD:270905	109/249 (44%)
		S_TKc	29..277	CDD:214567	109/250 (44%)
		UBA_MARK_Par1	295..332	CDD:270522	12/48 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810