DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and Gm4922

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_808374.1	Gene:	Gm4922 / 237300	MGIID:	3644318	Length:	497	Species:	Mus musculus

Alignment Length:	523	Identity:	160/523 - (30%)
Similarity:	241/523 - (46%)	Gaps:	110/523 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 YKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYR-------EVKIMKLLNHP 155
            |.::|||.:....:|:|..|..||..||:|.:           |..|       ||:|||:|:||
Mouse    28 YTVLKTLSQHGTTEVRLCSHHLTGVTVAVKAL-----------KYQRWWEPKVSEVEIMKMLSHP 81

  Fly   156 NIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFVVHRD 220
            |||.|.||||:|:.:||:||.|...:|.:.:.:...::|.:||.||.||:|||.|||.:.|||||
Mouse    82 NIVSLLQVIETEQNIYLIMEVAQGTQLHNRVQEARCLKEDEARSIFVQLLSAIGYCHGEGVVHRD 146

  Fly   221 LKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSLGVVL 285
            ||.:|:::|:|.|:||.|||.|..|.|..:||..||:..:..||:|:|..|.||:||.|:|||:|
Mouse   147 LKPDNVIVDEHGNVKIVDFGLGARFMPGQKLERLCGAFQFIPPEIFLGLPYDGPKVDIWALGVLL 211

  Fly   286 YTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSDKWIN 350
            |.:|:|..||.|.||.|:.:.||:|:|.:||.:|.|..:::...|..|..:|.:...::|..|:.
Mouse   212 YYMVTGIFPFVGSTLSEISKEVLQGRYEIPYNLSKDLRSMIGLLLATNARQRPTAQDLLSHPWLQ 276

  Fly   351 LG------HDESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLLGV 409
            .|      |...|...|         |......:.::|...:|:.:|:|.:.||:...||.||..
Mouse   277 EGEKTITFHSNGDTSFP---------DPDIMAAMKNIGFHVQDIRESLKHRKFDETMATYNLLRA 332

  Fly   410 AKPRSSNRSTKPEAIPTVDLTTPAVSSPLPNITTPTVTIAHVTLALDKNPPIHSSSASGRPIAPR 474
            ...:......:.:      |..|.:                        ||..|.:.||
Mouse   333 EACQDDGNYVQTK------LMNPGM------------------------PPFPSVTDSG------ 361

  Fly   475 LANAPNTPTSTPPTGPPAKPTRRTPARTPARKATNHTSGQGRPEPSSLPHTPQSKRASANMDVKP 539
                   ..|.||....::|:.:....:........|.|...|.|..  .||...|
Mouse   362 -------AFSLPPRRRASEPSFKVLVSSTEEHQLRQTGGTNAPFPPK--KTPTMGR--------- 408

  Fly   540 TLLSAQRQLAQTQKLANTPP-----RFQYPVAQ-----TPNQAQGSSRRPTTLYEKAEPAVTPLL 594
                     :|.||.|.|.|     |..|...:     |.:||:.:|..|    ||:|.:.:..|
Mouse   409 ---------SQKQKRAMTAPCICLLRNTYIDTEDSSFCTSSQAEKTSSDP----EKSETSTSCPL 460

  Fly   595 VPK 597
            .|:
Mouse   461 TPR 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	108/257 (42%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	108/257 (42%)
Gm4922	NP_808374.1	STKc_AMPK-like	27..274	CDD:270905	108/256 (42%)
		UBA_MARK_Par1	293..330	CDD:270522	10/45 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..410		7/46 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..460		7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810