DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and Sik2

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_848825.2	Gene:	Sik2 / 235344	MGIID:	2445031	Length:	931	Species:	Mus musculus

Alignment Length:	605	Identity:	215/605 - (35%)
Similarity:	315/605 - (52%)	Gaps:	95/605 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 GVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKLLNHPNIVRL 160
            |.|.|..||||||||.|||..|..|..|||||:|||:||:....:|:||||:|||:|:||:|::|
Mouse    18 GFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKL 82

  Fly   161 FQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFVVHRDLKAEN 225
            :||:|::..||||.|||..||:||:|..:||:.|.:||..|.|::||:.|||.:.||||||||||
Mouse    83 YQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKVVHRDLKAEN 147

  Fly   226 LLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSLGVVLYTLVS 290
            ||||.:||||||||||||.|.....|.|:||||||||||:|.|::|.||::|.||:|||||.||.
Mouse   148 LLLDNNMNIKIADFGFGNFFKTGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVC 212

  Fly   291 GSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSDKWINLGHDE 355
            |:|||||.||..||:|||.|::|:||::|.|||:|:|:.|||:|:||.|::.:...||:.:   |
Mouse   213 GALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLSIAQIKEHKWMLI---E 274

  Fly   356 SDRLRPFREKPMELQD---AARFD-----LLMSMGHKRRDVEQSVKGQLFDDIYCTYMLLGVAKP 412
            ....||.. .|.|.::   ...|:     |:.|:|..::...:|::.:.::.....|.||  .:.
Mouse   275 VPVQRPIL-YPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTVESLQNKSYNHFAAIYFLL--VER 336

  Fly   413 RSSNRSTKPEAIPTVDLTTPAVSSPLPNITTPTVTIAHVTLALDKNPPIHSSSASGRPIA----- 472
            ..|:||:.|            |...|........|||..|:|        .:...|.|:.
Mouse   337 LKSHRSSFP------------VEQRLDGRQRRPSTIAEQTVA--------KAQTVGLPVTLHPPN 381

  Fly   473 ---------PRLAN--APNTPTS---------------TPPTG-------PPAKPTRRTPARTPA 504
                     |:.:|  |.:.|||               ||...       ||....:...:...:
Mouse   382 VRLMRSTLLPQASNVEAFSFPTSSCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSS 446

  Fly   505 RKATN-----HTSGQGRPEPSSLPHTPQSKRASANMDVKPTLLSAQRQLAQTQKLANTPPRFQYP 564
            ...|:     .|.|:...:||......|:.|:...   :.||.....||........     .:.
Mouse   447 MMETSIDEGLETEGEAEEDPSQAFEAFQATRSGQR---RHTLSEVTNQLVVMPGAGK-----MFS 503

  Fly   565 VAQTPN-------QAQGSSRRPTTLYEKAEPAVTPLLVPK--SPAMGARLLERIPGGGAVEKTSD 620
            ::..|:       ...||::|.....|.: |::..:::..  ||.|.:..:...|...|::..|.
Mouse   504 MSDNPSLESVDSEYDMGSAQRDLNFLEDS-PSLKDIMLANQPSPRMTSPFISLRPANPAMQALSS 567

  Fly   621 KPFTRQNVARATFHFGQARS 640
            :.....|.:..:|..|:..|
Mouse   568 QKREAHNRSPVSFREGRRAS 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	150/250 (60%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	150/250 (60%)
Sik2	NP_848825.2	STKc_SIK	19..271	CDD:270973	150/251 (60%)
		S_TKc	20..271	CDD:214567	150/250 (60%)
		UBA_SIK2	297..341	CDD:270592	8/45 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..586		4/20 (20%)
		RK-rich region, required for cAMP responsiveness. /evidence=ECO:0000269\|PubMed:29211348	595..624
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..662
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..768
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..842
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.770