DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and SIK2

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_056006.1	Gene:	SIK2 / 23235	HGNCID:	21680	Length:	926	Species:	Homo sapiens

Alignment Length:	644	Identity:	215/644 - (33%)
Similarity:	312/644 - (48%)	Gaps:	160/644 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 GVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKLLNHPNIVRL 160
            |.|.|..||||||||.|||..|..|..|||||:|||:||:....:|:||||:|||:|:||:|::|
Human    18 GFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKL 82

  Fly   161 FQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFVVHRDLKAEN 225
            :||:|::..||||.|||..||:||:|..:||:.|.:||..|.|::||:.|||.:.:|||||||||
Human    83 YQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAEN 147

  Fly   226 LLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSLGVVLYTLVS 290
            ||||.:||||||||||||.|.....|.|:||||||||||:|.|::|.||::|.||:|||||.||.
Human   148 LLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVC 212

  Fly   291 GSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSDKWINL---- 351
            |:|||||.||..||:|||.|::|:||::|.|||:|:|:.|||:|:||.:::.:...||:.:
Human   213 GALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPV 277

  Fly   352 --------GHDESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLLG 408
                    ..:....:..|.|:.:.        |:.|:|..::...:|::.:.::.....|.||
Human   278 QRPVLYPQEQENEPSIGEFNEQVLR--------LMHSLGIDQQKTIESLQNKSYNHFAAIYFLL- 333

  Fly   409 VAKPRSSNRSTKPEAIPTVDLTTPAVSSPLPNITTPTVTIAHVTLALDKNP--PIHSSSASGR-- 469
             .:...|:||:.|            |...|........|||..|:|..:..  |:...|.:.|
Human   334 -VERLKSHRSSFP------------VEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLL 385

  Fly   470 --PIAPRLAN--APNTPTS---------------TPPTG-------PPA---KPTRRTPARTPAR 505
              .:.|:.:|  |.:.|.|               ||...       ||.   |..:..|:.....
Human   386 RSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMET 450

  Fly   506 KATN--HTSGQGRPEPSSLPHTPQSKRASA----------------------NMDVKPTL--LSA 544
            ....  .|.|:...:|:......||.|:..                      :|:..|:|  :.:
Human   451 SIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDS 515

  Fly   545 QRQLAQTQK---------------LANTP-PRFQYP-VAQTPN----QAQGSSRR------PTT- 581
            :..:...|:               |||.| ||...| ::..|.    ||..|.:|      |.:
Human   516 EYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSF 580

  Fly   582 ---------------------------------------LYEKAEPAVTPLLVPKSPAM 601
                                                   |||:..|...|.|.|.:|.:
Human   581 REGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQL 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	148/250 (59%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	148/250 (59%)
SIK2	NP_056006.1	STKc_SIK	19..271	CDD:270973	148/251 (59%)
		UBA_SIK2	297..341	CDD:270592	9/53 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..666
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..776
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..896
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770