DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and Mark1

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001365805.1	Gene:	Mark1 / 226778	MGIID:	2664902	Length:	796	Species:	Mus musculus

Alignment Length:	729	Identity:	290/729 - (39%)
Similarity:	403/729 - (55%)	Gaps:	125/729 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SEKTAMTAANKENDPDSHFTGTIVTTGATAQPATPTTSNATA-LPATPTVAAGQDLGDGACSSKN 81
            |.:|.:...| |.|.::|.:    ..|.|.....|..|::.. ||              .|.:..
Mouse     2 SARTPLPTVN-ERDTENHTS----VDGYTETHIPPAKSSSRQNLP--------------RCRNSI 47

  Fly    82 TDSKFQSYVNGNGNGVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREV 146
            |.:..:....||    |::.||:|||||||||||.||.||||||:|:|||||||.::.|||:|||
Mouse    48 TSATDEQPHIGN----YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREV 108

  Fly   147 KIMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYC 211
            :|||:|||||||:||:|||:|:||||||||||.||:||:||.:|||:|::||..|||:|||:|||
Mouse   109 RIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 173

  Fly   212 HSKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEV 276
            |.|.:|||||||||||||..||||||||||.|.|....:|:||||||||||||||.|:||.||||
Mouse   174 HQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEV 238

  Fly   277 DAWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLS 341
            |.|||||:|||||||||||||..||||||||||||||:|:|:|.|||||::|.|||||.||.||.
Mouse   239 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLE 303

  Fly   342 AVMSDKWINLGHDESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYML 406
            .:|.|:|:|:||:| :.|:|:.|..::|.||.|.|::::||..|.::..::..|.:|::..||:|
Mouse   304 QIMKDRWMNVGHEE-EELKPYSEPELDLSDAKRIDIMVTMGFARDEINDALVSQKYDEVMATYIL 367

  Fly   407 LGVAKPR------SSNRSTKPEAIPTVDLTTPAVSSPL----------------------PNITT 443
            ||...|.      .|:.|....:.|:.||....:.||.                      |:| .
Mouse   368 LGRKPPEFEGGESLSSGSLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGPSI-P 431

  Fly   444 PTVTIAHVTLALDKNPPIHSSSAS-----GRPIAPRLAN----APNTPTSTPPTGPPAKPTRRTP 499
            |.|:..       |.|..:|..:.     |:..|.||.:    :.:..|::|..||..|.:..:|
Mouse   432 PAVSYT-------KRPQANSVESEQKEEWGKDTARRLGSTTVGSKSEVTASPLVGPDRKKSTASP 489

  Fly   500 AR------TPAR-------KATNHTSGQGRPEPSSLPHTPQSKRASANMDVKPTLLSAQRQLAQT 551
            :.      :.||       ::|:..:.......|||.....|..:||...|.....||:.:..::
Mouse   490 SNNVYSGGSMARRNTYVCERSTDRYAALQNGRDSSLTEMSASSMSSAGSTVASAGPSARPRHQKS 554

  Fly   552 QKLANTPPRFQYPVAQTPNQAQGSSRRPTTLYEKAEPAVTPLLVPKSPAMGARLLERIPGGGAVE 616
            ...:..|.:...|..:..::|.    ||.:..::     .|...|.:.::.|
Mouse   555 MSTSGHPIKVTLPTIKDGSEAY----RPGSAAQR-----VPAASPSAHSISA------------- 597

  Fly   617 KTSDKP-FTRQNVARATFHFGQARSGKRGGGSGNGAGGEEDSYQTPPLSAD-------DTKPASR 673
            .|.|:. |.|.:.:|:|||..|.|..:..            :|..||.|..       ..:..:.
Mouse   598 STPDRTRFPRGSSSRSTFHGEQLRERRSA------------AYNGPPASPSHETGAFAHARRGTS 650

  Fly   674 VGFFSKLTARFGRR 687
            .|..||:|::|.||
Mouse   651 TGIISKITSKFVRR 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	185/250 (74%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	185/250 (74%)
Mark1	NP_001365805.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		10/43 (23%)
		STKc_MARK	59..311	CDD:270974	186/255 (73%)
		UBA_like_SF	331..371	CDD:419673	14/39 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..498		24/128 (19%)
		MARK1-3_C	697..794	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43270
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910