Protein Alignment KP78a and Snrk

DIOPT Version :10

• Sequence 1: NP_650066.1
• Gene: KP78a / 41362
• FlyBaseID: FBgn0026064
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_598502.2
• Gene: Snrk / 20623
• MGIID: 108104
• Length: 748
• Species: Mus musculus
• Alignment Length: 669
• Identity: 196/669 - (29%)
• Similarity: 286/669 - (42%)
• Gaps: 160/669 - (23%)

  Fly    86 FQSYVNGNGNGVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMK 150
            |:...:|...|:|.:.||||:|:||.||||.||.||.:||:||||||:|:|.|...|::||:.||
Mouse     4 FKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMK 68

  Fly   151 LLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGR-MRERDARVIFRQLVSAIQYCHSK 214
            |:.|||||||::||:::..|||::|....|::||:::|:.. :.|..|:..|.|:|.||.|||..
Mouse    69 LVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133

  Fly   215 FVVHRDLKAENLLLDQHMN-IKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDA 278
            .|||||||.||::..:... :|:.||||.|.|.|..:|.|.|||..|:|||:.:|.:|..|.||.
Mouse   134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDI 198

  Fly   279 WSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAV 343
            |||||:|:.||.|..||......|....::..||.||..:|..|.:|:.:.|..:|.:|.||..:
Mouse   199 WSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPPRVSAGCRDLITRMLQRDPKRRASLEEI 263

  Fly   344 MSDKWI-------------------NLGHDESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVE 389
            .|..|:                   ||..:|.:.:    .:.|.|.|.|..|.::
Mouse   264 ESHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSI----IQRMVLGDIADRDAIV---------- 314

  Fly   390 QSVKGQLFDDIYCTYMLLGVAKPRS------SNRSTKPEAI--------PT-----VDLTTPAVS 435
            ::::...::.|..||.||.....|.      ..||..|..|        ||     .||.....:
Mouse   315 EALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDDLTA 379

  Fly   436 SPLPNITTP--------TVTIAHVTLALDKNPPIHSSSASGRPIAPRLANAPNTPTSTPPTGPPA 492
            :||.:.|.|        .|...|.:..|        ...:.:...|.|| .|...|..|.:..||
Mouse   380 TPLSHATVPQSPARAGDNVLNGHRSKGL--------CDPAKKDELPELA-GPALSTVPPASMKPA 435

  Fly   493 KPTRRTPARTPARKATNHTSGQGRPEPSSLPHTPQSKRASANMDVKPTLLSAQ----RQLAQTQK 553
            ...|:...|.                        :........|.||..||.|    |:.:.|.:
Mouse   436 ASGRKCLFRV------------------------EEDEEEDEEDKKPVSLSTQVVLRRKPSVTNR 476

  Fly   554 LANTPPRFQYPVAQTPNQ--AQGSSRRPTTLYEKAEPAVTPLLVPKSPAMGARLLERIPGGGAVE 616
            |.:   |...||.   ||  .:|.|.....:.|...|.:            :||...|...|.|.
Mouse   477 LTS---RKSAPVL---NQIFEEGESDDEFDMDENLPPKL------------SRLKMNIASPGTVH 523

  Fly   617 KTSDKPFTRQNVARATFHFGQARSGKRGGGSGNGAGGEE---------------------DSYQT 660
            |                .:.:.:|..||....:....::                     ||.:.
Mouse   524 K----------------RYHRRKSQGRGSSCSSSETSDDDSESRRRLDKDSGFAYSWHRRDSSEG 572

  Fly   661 PPLSADD----TKPASRVG 675
            ||.|..|    :||:|..|
Mouse   573 PPGSEGDGGGQSKPSSGGG 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	Protein Kinases, catalytic domain	98..349	CDD:473864	116/252 (46%)
		UBA_MARK_Par1	370..408	CDD:270522	7/37 (19%)
Snrk	NP_598502.2	STKc_SNRK	12..269	CDD:270976	117/256 (46%)
		UBA_SNRK	288..335	CDD:270524	13/60 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..415		5/39 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	491..640		23/129 (18%)