DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and MARK2

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_011543091.1	Gene:	MARK2 / 2011	HGNCID:	3332	Length:	808	Species:	Homo sapiens

Alignment Length:	715	Identity:	302/715 - (42%)
Similarity:	412/715 - (57%)	Gaps:	120/715 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 LPATPTV------AAGQDLG--DGACSSKN---------TDSKFQSYVNGNGNGVYKIIKTLGKG 107
            :||...:      .||..||  |...|||:         |.:..|.::     |.|:::||:|||
Human    23 IPAVGNILQHRRRGAGPTLGHLDSKPSSKSNMIRGRNSATSADEQPHI-----GNYRLLKTIGKG 82

  Fly   108 NFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKLLNHPNIVRLFQVIESERTLYL 172
            ||||||||.|:.||:|||:|:|||||||:|:.|||:|||:|||:|||||||:||:|||:|:||||
Human    83 NFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYL 147

  Fly   173 VMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFVVHRDLKAENLLLDQHMNIKIA 237
            ||||||.||:||:||.:|||:|::||..|||:|||:||||.||:|||||||||||||..||||||
Human   148 VMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIA 212

  Fly   238 DFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSLGVVLYTLVSGSLPFDGGTLKE 302
            ||||.|.|....:|:||||||||||||||.|:||.|||||.|||||:|||||||||||||..|||
Human   213 DFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE 277

  Fly   303 LRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSDKWINLGHDESDRLRPFREKPM 367
            |||||||||||:|:|:|.|||||::|||:|||:||.:|..:|.|:|:|:|| |.|.|:|:.|...
Human   278 LRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGH-EDDELKPYVEPLP 341

  Fly   368 ELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLLGVAKPRSSNRSTKPEAIPTVDLTTP 432
            :.:|..|.:|::|||:.|.:::.|:.||.::::..||:|||.........:...:..|:.|||..
Human   342 DYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNS 406

  Fly   433 AVSSPLPNITTPTVTIAH-VTLALDKNPPIH--SSSASGRPIAP---------RLANAPN-TPTS 484
            :..||           :| |..::..||...  |..|:| |..|         :..||.| .|..
Human   407 SAPSP-----------SHKVQRSVSANPKQRRFSDQAAG-PAIPTSNSYSKKTQSNNAENKRPEE 459

  Fly   485 TPPTGPPAKPTRRTPARTP----ARKATNHTSGQGRPEPSSLPHT--------PQSKRASANMDV 537
            ...:|..|..|.:.|| :|    .||.|..|     |..:|:..|        |..:|||..
Human   460 DRESGRKASSTAKVPA-SPLPGLERKKTTPT-----PSTNSVLSTSTNRSRNSPLLERASLG--- 515

  Fly   538 KPTLLSAQRQLAQTQKLANT-----------PPRFQYPVAQT--PNQAQGSSRRPT-TLYEKAEP 588
            :.::.:.:..|......|:|           |.:.|..::.:  ||:|.|..  || :..|...|
Human   516 QASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLP--PTESNCEVPRP 578

  Fly   589 AVTPLLVPKSPAMGARLLERIPGGGAVEKTSDKPFTRQNVARATFHFGQARSGKRGGGSGNGAGG 653
            :..|..||.:......:..   .|||.::|:   |.|...:|:|||.||.|..:
Human   579 STAPQRVPVASPSAHNISS---SGGAPDRTN---FPRGVSSRSTFHAGQLRQVR----------- 626

  Fly   654 EEDSYQTPPLSADDTKPA----SRVG----FFSKLTARFGRRVI-------HLNEKDVTEQRKNL 703
               ..|..|.......|:    .|.|    .|||.|::|.||.:       :|||.:..::.:.|
Human   627 ---DQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETL 688

Fly 704 703
Human 689 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	184/250 (74%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	184/250 (74%)
MARK2	XP_011543091.1	STKc_MARK	72..324	CDD:270974	184/251 (73%)
		S_TKc	73..324	CDD:214567	184/250 (74%)
		UBA_MARK2	342..383	CDD:270589	14/40 (35%)
		MARK2_C	709..807	CDD:213386
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910