DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and par-1

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001122967.2	Gene:	par-1 / 179912	WormBaseID:	WBGene00003916	Length:	1216	Species:	Caenorhabditis elegans

Alignment Length:	741	Identity:	295/741 - (39%)
Similarity:	396/741 - (53%)	Gaps:	144/741 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 IVTTGATAQPATPTTSNATALPATPTVAAGQDLGDGACSSKNTDSKFQSYVNGNGN--------- 95
            :|||.    |..||   .|:.....||....| ||....::...|   |:....|.
Worm    41 VVTTA----PMAPT---LTSSGKRRTVKVSPD-GDHVTHNRKNSS---SHARSTGQSGMSSRSAA 94

  Fly    96 ---------GVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKL 151
                     |.||::||:|||||||||||.||.||.|||||:||||.||.|:.|||:|||||||.
Worm    95 RRNDQDVHVGKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQ 159

  Fly   152 LNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFV 216
            |:|||||:|:||:|:|:|||||:||||.||:||:||.:|||:|::||..|||:|||:||.|||.:
Worm   160 LDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNI 224

  Fly   217 VHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSL 281
            :|||||||||||||.||||||||||.|||....:|:||||||||||||||.|:||.|||||.|||
Worm   225 IHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSL 289

  Fly   282 GVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSD 346
            ||:|||||||||||||..||||||||||||||:|:|:|.|||||::||||:||.:|:||..:|.|
Worm   290 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKD 354

  Fly   347 KWINLGHDESDRLRPFREKPMELQDAARFDLLM---SMGHKRRDVEQSVKGQLFDDIYCTYMLLG 408
            :|:|:|: |.|.|:||.|.|.:..|..|.:.|:   .:|..:..:.:||:.:.|:||:.||:|||
Worm   355 RWMNVGY-EDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATYLLLG 418

  Fly   409 VAK-PRSSNRSTKPEAIPTVDLTTPAVSSPLPNITTPTVTIAHVTLALDKNPPIHSSSASGRPIA 472
            ..| ...::..|..:::  :..::..|||.|.......:|..|||          ||||||...:
Worm   419 ERKSDMDASEITMAQSL--LSHSSINVSSSLGQHPAGVITREHVT----------SSSASGSSAS 471

  Fly   473 P-------------------RLANAPNT-----PTSTPPTGPPAKPTRRTPARTPARKA------ 507
            |                   .||:|.|.     .::.|.:|  :..:||:.....|..|
Worm   472 PSRYSRSSATATGASITAGSALASAANAQKHQQSSAAPSSG--SSSSRRSSQNDAAATAAGGTVV 534

  Fly   508 ---TNHTSGQGRPEPSSLPHT-----PQSKRASANMDVKPTLLSAQRQLAQTQKLANTPPRFQYP 564
               |.|...|.|.:|:|...|     |.|.:.|:|                |.::|..||.|...
Worm   535 MSGTRHGGVQMRAQPTSRQATISLLQPPSYKPSSN----------------TTQIAQIPPLFNRN 583

  Fly   565 VAQTPNQAQGSSRRPTTLYEKAEPAVTPLLVPKSPAMGARLLE----RIP-----------GGGA 614
            ...|.:.||                      |.:...|.|.:.    |||           ..||
Worm   584 STATSSAAQ----------------------PSTGITGTRKIADPKGRIPLNSTAVQGHRTATGA 626

  Fly   615 VEKTSDKPFTRQNVARATFHFGQARSGKRGGGSGN---GAGGEEDSYQTPPLSADDTKPASRVGF 676
            |...:....:.::.|:...:..|..|........|   .|||...:..:...||..|.|..:.|
Worm   627 VAANNGGIPSHRDHAQQQQYMNQLTSSTMMSKLINKTPAAGGTAATSSSSSSSATSTAPLQKSG- 690

  Fly   677 FSKLTARFGRRVIHLNEKDVTEQRKN 702
             |:::......||..::.:...:.:|
Worm   691 -SQISHAPTEPVIREDDDENNSENQN 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	184/250 (74%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	184/250 (74%)
par-1	NP_001122967.2	STKc_MARK	105..357	CDD:270974	184/251 (73%)
		S_TKc	106..357	CDD:214567	184/250 (74%)
		MARK1-3_C	1117..1214	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010