DRSC/TRiP Functional Genomics Resources

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Protein Alignment KP78a and Sik1

DIOPT Version :9

Sequence 1:NP_650066.1 Gene:KP78a / 41362 FlyBaseID:FBgn0026064 Length:705 Species:Drosophila melanogaster
Sequence 2:NP_034961.2 Gene:Sik1 / 17691 MGIID:104754 Length:779 Species:Mus musculus


Alignment Length:664 Identity:225/664 - (33%)
Similarity:328/664 - (49%) Gaps:115/664 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 SKFQSYVNGNGN--------GVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQ 140
            |:|.:..:|.|.        |.|.:.:||||||||.||||.|..|..:||||:||||:|::|..:
Mouse     5 SEFSAVPSGTGQGQQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLE 69

  Fly   141 KLYREVKIMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLV 205
            |:||||::|||||||||::|:||:|::..||:|.|:|..||:||:|..||.:.|.:||..|.|::
Mouse    70 KIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARQKFWQIL 134

  Fly   206 SAIQYCHSKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRK 270
            ||::|||:..:||||||.||||||.:|:||:|||||||.:.|...|.|:||||||||||:|.|::
Mouse   135 SAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKE 199

  Fly   271 YAGPEVDAWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPA 335
            |.||::|.||||||||.||.|||||||..|..||:|||.|::|:|:::|.|||.|:|:.||::||
Mouse   200 YEGPQLDVWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPA 264

  Fly   336 KRTSLSAVMSDKWIN-----LGHDE--------SDRLRPFREKPMELQDAARFDLLMSMGHKRRD 387
            ||.:::.:...:|:.     |..|:        :..|..:.|:.:.:..|...|       ::|.
Mouse   265 KRITIAQIRQHRWMQADPTLLQQDDPAFDMQGYTSNLGDYNEQVLGIMQALGID-------RQRT 322

  Fly   388 VE--QSVKGQLFDDIYCTYMLLGVAKP-RSSNRSTKPEAIPT-------VDLTT----------- 431
            :|  |:.....|..||  |:||...|. ||:..|::|...||       .||::           
Mouse   323 IESLQNSSYNHFAAIY--YLLLERLKEHRSAQPSSRPTPAPTRQPQLRSSDLSSLEVPQEILPCD 385

  Fly   432 ---PAVSSPLPNITTPTVTIAHVTLALDKNPPIHSS----------SASG----RPIAPRLANAP 479
               |::..|.|.....:|..|.:...|      |||          :.||    |.|:|  ::..
Mouse   386 PFRPSLLCPQPQALAQSVLQAEIDCDL------HSSLQPLLFPLDTNCSGVFRHRSISP--SSLL 442

  Fly   480 NTPTSTPP-TGPPAKPTRRTPARTPARKATNHT-------------------------SGQGRPE 518
            :|..|... .||..:..:......|......||                         ..:|...
Mouse   443 DTAISEEARQGPSLEEEQEVQEPLPGSTGRRHTLAEVSTHFSPLNPPCIIVSSSATASPSEGTSS 507

  Fly   519 PSSLPHTPQSKRASANMDV-KPTLLSAQRQLAQTQKLANTPPRFQYPVAQTPNQAQGSSRRPTTL 582
            .|.||.:.....|.....: .|.||.....:........:  :...||.|| ....|::..|...
Mouse   508 DSCLPFSASEGPAGLGSGLATPGLLGTSSPVRLASPFLGS--QSATPVLQT-QAGLGTAVLPPVS 569

  Fly   583 YEKAEPAVTPLLVPKSPAMGARLLERIPGGGAVEKTSDKPFTRQ---------NVARATFHFGQA 638
            :::...|....|.....|...:|.:.....|.:.....|...||         ....:|||....
Mouse   570 FQEGRRASDTSLTQGLKAFRQQLRKNARTKGFLGLNKIKGLARQVCQSSVRTPRGGMSTFHTPAP 634

  Fly   639 RSGKRGGGSGNGAG 652
            .||.:|..:.|..|
Mouse   635 SSGLQGCTTSNREG 648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KP78aNP_650066.1 PKc_like 98..349 CDD:304357 144/250 (58%)
S_TKc 98..349 CDD:214567 144/250 (58%)
Sik1NP_034961.2 STKc_SIK 26..278 CDD:270973 144/251 (57%)
S_TKc 27..278 CDD:214567 144/250 (58%)
UBA_SIK1 300..349 CDD:270591 14/57 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..375 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..472 3/22 (14%)
RK-rich region 586..612 4/25 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 621..641 5/19 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0586
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
32.770

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