DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and Mark3

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_006515574.1	Gene:	Mark3 / 17169	MGIID:	1341865	Length:	806	Species:	Mus musculus

Alignment Length:	743	Identity:	299/743 - (40%)
Similarity:	414/743 - (55%)	Gaps:	117/743 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SEKTAMTAANKENDPDSHFTGTIVTTGATAQPATPTTSNATALPATPTVAAGQDLGDGACSSKNT 82
            |.:|.:...| |.|.::|     ::.|...|..|..|..:.| ....::|        :|:.:
Mouse     2 STRTPLPTVN-ERDTENH-----ISHGDGRQEVTSRTGRSGA-RCRNSIA--------SCADE-- 49

  Fly    83 DSKFQSYVNGNGNGVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVK 147
                |.::     |.|:::||:|||||||||||.|:.||||||||:|||||||.::.|||:|||:
Mouse    50 ----QPHI-----GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVR 105

  Fly   148 IMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCH 212
            |||:|||||||:||:|||:|:||||:|||||.||:||:||.:|||:|::||..|||:|||:||||
Mouse   106 IMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 170

  Fly   213 SKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVD 277
            .|.:|||||||||||||..||||||||||.|.|...::|:||||||||||||||.|:||.|||||
Mouse   171 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVD 235

  Fly   278 AWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSA 342
            .|||||:|||||||||||||..||||||||||||||:|:|:|.|||||:::||||||.||.:|..
Mouse   236 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQ 300

  Fly   343 VMSDKWINLGHDESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLL 407
            :|.|:|||.||:| |.|:||.|..:::.|..|.|:::.||:.:.::::|:....:|:|..||:||
Mouse   301 IMKDRWINAGHEE-DELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLL 364

  Fly   408 G-------VAKPRSSNRSTKPEAIPTVDLTTPAVSSP------------------------LPNI 441
            |       .:...||:..:..:..|..||:.....||                        :|::
Mouse   365 GRKSAELDASDSSSSSNLSLAKVRPNSDLSNSTGQSPHHKGQRSVSSSQKQRRYSDHAGPAIPSV 429

  Fly   442 TT----PTVTIAHVTLALDKNPPIHSSSAS--GRPIAPRLANAPNTPTSTPPTGPPAKPTRRTPA 500
            ..    ...:.|...|..|..|...|||::  |:.|||          ::|..|....|.:   |
Mouse   430 VAYPKRSQTSTADSDLKEDGIPSRKSSSSAVGGKGIAP----------ASPMLGNAGNPNK---A 481

  Fly   501 RTPARKATNHTSGQGRPEPSSLPHTPQSKRASANMDVKPTLLSAQR------QLAQTQKLANTPP 559
            ..|.||.:              |..|.|..||..|..:.|.:.::|      .:.|..|..:...
Mouse   482 DIPERKKS--------------PAVPSSNTASGGMTRRNTYVCSERCAADRHSVIQNGKENSLTE 532

  Fly   560 RFQYPVAQTPNQAQGSSR----RPTTLYEKAEP-AVTPLLVPKSPAMGARLL--ERIPGGG---- 613
            .|.|..:.....|..:.|    |..::.....| .|.|.:..:.....|..:  ||.|...
Mouse   533 VFAYAASPASLCATSTCRLRHQRSMSVSASGHPKMVLPPIDSEGDTFKAIAIPDERTPVASTHSI 597

  Fly   614 AVEKTSDK-PFTRQNVARATFHFGQARSGKRGGGSGNGAGGEED-SYQTPPLSADDTKPASRVGF 676
            :...|.|: .|.|...:|:||| ||.|  :|...:.||...... |::..|||  .|:.......
Mouse   598 SSATTPDRIRFPRGTASRSTFH-GQPR--ERRTATYNGPPASPSLSHEATPLS--QTRSRGSTNL 657

  Fly   677 FSKLTARFGRRVIHLN--EKDVTEQRKN 702
            |||||::..||.:...  ::..||..:|
Mouse   658 FSKLTSKLTRRNMSFRFIKRLPTEYERN 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	183/250 (73%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	183/250 (73%)
Mark3	XP_006515574.1	STKc_MARK	55..307	CDD:270974	183/251 (73%)
		UBA_MARK3_4	325..367	CDD:270590	13/41 (32%)
		MARK1-3_C	707..804	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43270
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810