DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and Mark1

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_038946210.1	Gene:	Mark1 / 117016	RGDID:	619882	Length:	794	Species:	Rattus norvegicus

Alignment Length:	724	Identity:	287/724 - (39%)
Similarity:	398/724 - (54%)	Gaps:	115/724 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SEKTAMTAANKENDPDSHFTGTIVTTGATAQPATPTTSNATA-LPATPTVAAGQDLGDGACSSKN 81
            |.:|.:...| |.|.::|.:    ..|.|.....||.|::.. :|              .|.:..
  Rat     2 SARTPLPTVN-ERDTENHTS----VDGYTETHIPPTKSSSRQNIP--------------RCRNSI 47

  Fly    82 TDSKFQSYVNGNGNGVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREV 146
            |.:..:....||    |::.||:|||||||||||.||.||||||:|:|||||||.::.|||:|||
  Rat    48 TSATDEQPHIGN----YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREV 108

  Fly   147 KIMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYC 211
            :|||:|||||||:||:|||:|:||||||||||.||:||:||.:|||:|::||..|||:|||:|||
  Rat   109 RIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 173

  Fly   212 HSKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEV 276
            |.|.:|||||||||||||..||||||||||.|.|....:|:||||||||||||||.|:||.||||
  Rat   174 HQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEV 238

  Fly   277 DAWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLS 341
            |.|||||:|||||||||||||..||||||||||||||||:|:|.|||||::|.|||||.||.||.
  Rat   239 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRVPFYMSTDCENLLKKLLVLNPIKRGSLE 303

  Fly   342 AVMSDKWINLGHDESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYML 406
            .:|.|:|:|:||:| :.|:|:.|..::|.||.|.|::::||..|.::..::..|.:|::..||:|
  Rat   304 QIMKDRWMNVGHEE-EELKPYSEPELDLNDAKRIDIMVTMGFARDEINDALVSQKYDEVMATYIL 367

  Fly   407 LGVAKPR--------SSNRSTKPEAIPTVDLTTPAVSSPL----------------------PNI 441
            ||...|.        |.|...:..  |:.||....:.||.                      |:|
  Rat   368 LGRKPPEFEGGESLSSGNLCQRSR--PSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGPSI 430

  Fly   442 TTPTVTIAHVTLALDKNPPIHSSSA---------SGRPIAPRLANAPNTPTSTPPTGPPAKPTRR 497
             .|.|:..       |.|..:|..:         :.|.:......:.:..|::|..||..|.:..
  Rat   431 -PPAVSYT-------KRPQANSVESEQKEEWDKDTARRLGSTTVGSKSEVTASPLVGPDRKKSSA 487

  Fly   498 TPART-------------PARKATNHTSGQGRPEPSSLPHTPQSKRASANMDVKPTLLSAQRQLA 549
            .|:..             ...::|:..:.......|||.....|..:|....|.....||:.:..
  Rat   488 GPSNNVYSGGSMTRRNTYVCERSTDRYAALQNGRDSSLTEMSASSMSSTGSTVASAGPSARPRHQ 552

  Fly   550 QTQKLANTPPRFQYPVAQTPNQAQGSSRRPTTLYEKAEPAVTPLLVPKSPAMGARLLERIPGGGA 614
            ::...:..|.:...|..:..::|.    ||.:..::     .|...|.:.::.|
  Rat   553 KSMSTSGHPIKVTLPTIKDGSEAY----RPGSTAQR-----VPAASPSAHSISA----------- 597

  Fly   615 VEKTSDKP-FTRQNVARATFHFGQARSGKRGGGSGNGAGGEEDSYQTPPLSADDTKPASRVGFFS 678
              .|.|:. |.|.:.:|:|||..|.|..:....||..|   ..|:.|..|:  ..:..:..|..|
  Rat   598 --STPDRTRFPRGSSSRSTFHGEQLRERRSAAYSGPPA---SPSHDTAALA--HARRGTSTGIIS 655

  Fly   679 KLTARFGRR 687
            |:|::|.||
  Rat   656 KITSKFVRR 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	186/250 (74%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	186/250 (74%)
Mark1	XP_038946210.1	STKc_MARK	59..311	CDD:270974	187/255 (73%)
		UBA_MARK1	331..371	CDD:270588	14/39 (36%)
		MARK1-3_C	695..792	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45341
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24346
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910