DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and Mapk7

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001178476.1	Gene:	Mapk7 / 114509	RGDID:	621505	Length:	812	Species:	Rattus norvegicus

Alignment Length:	747	Identity:	168/747 - (22%)
Similarity:	265/747 - (35%)	Gaps:	241/747 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 YKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKT-QLNTSARQKLYREVKIMKLLNHPNIVRLF 161
            |:||:|:|.|.:..|..|....||::||||.|... .:.|:|::.| ||:||:|...|.||:.:.
  Rat    55 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTL-RELKILKHFKHDNIIAIK 118

  Fly   162 QVIESE------RTLYLVME----------YASRGELFDHLVKNGRMRERDARVIFRQLVSAIQY 210
            .::...      |::|:|::          ::|:....:|:           |....||:..::|
  Rat   119 DILRPTVPYGEFRSVYVVLDLMESDLHQIIHSSQPLTLEHV-----------RYFLYQLLRGLKY 172

  Fly   211 CHSKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPP--------------YA 261
            .||..|:|||||..|||::::..:||.|||..         ...|.||.              |.
  Rat   173 MHSAQVIHRDLKPSNLLVNENCELKIGDFGMA---------RGLCTSPAEHQYFMTEYVATRWYR 228

  Fly   262 APELFMGRKYAGPEVDAWSLGVVLYTLVSGSLPFDG--------------GTLKEL------RER 306
            ||||.:........:|.||:|.:...:::....|.|              ||....      .||
  Rat   229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAER 293

  Fly   307 V------LRGKYRVPY---YISMDCE--NLMRKFLVLNPAKRTSLSAVMSDKWINLGH---DESD 357
            |      |..:..||:   |...|.:  :|:.:.|...|:.|.|.:|.:...::...|   ||.|
  Rat   294 VRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPD 358

  Fly   358 RLRPF----------REKPMELQDAARFDLLMSMGHKRRD-VEQSVKGQLFDDIYCTYMLLGVAK 411
            ...||          ||:..|...|...|.     |.||: :.|.::.|
  Rat   359 CAPPFDFAFDREALTRERIKEAIVAEIEDF-----HARREGIRQQIRFQ---------------- 402

  Fly   412 PRSSNRSTKPEAIPTVDLTTP-------AVSSP---LPNITTPTVTIAHVTL-----ALDKNPPI 461
            |.....:::| ..|.|::.:|       |:.||   ||..:.|......:||     |.:..||.
  Rat   403 PSLQPVASEP-VCPDVEMPSPWAPSGDCAMESPPPALPPCSGPAPDTVDLTLQPAPPASELAPPK 466

  Fly   462 HSSSASG-----------RPIAPRLANAPNTPTSTPPTGPPAKPTRRTPARTPARKATNHTSGQ- 514
            ...:.|.           :.:..||.:.|:.|...|....|.....|...|...|:.....:.:
  Rat   467 REGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKER 531

  Fly   515 -----------------GRPEPSSL---------------------PHTPQSKRASANMDVKPTL 541
                             |.|....|                     |..|....|.|... |||.
  Rat   532 EKRRQERERKERGAGTLGGPSTDPLAGLVLSDNDRSLLERWTRMARPPVPAPAPAPAPTP-KPTP 595

  Fly   542 LSAQRQLAQTQKLANTPPRFQYPVAQT--PNQAQGSSRRPTT---------LYEKAEPAVTPL-L 594
            ...|.....|     :||  ..||:|:  |.|..||...|.:         :.:.|.|...|| .
  Rat   596 TPTQSSAQPT-----SPP--NGPVSQSTAPLQPAGSIPGPASQPVCPPPGPVPQPAGPVPAPLQT 653

  Fly   595 VPKSPAMGARLL---ERIPGGGAVE--------------------KTSDKPFTRQNVARATFHFG 636
            .|.:..:.::.|   ..:||.||.|                    .||:.|    :|...|....
  Rat   654 APSTSLLASQSLVPPSGLPGSGAPEVLPYFPSGPPPPDPGLTPQPSTSESP----DVNLVTQQLS 714

  Fly   637 QAR---------SG-KRGGGSGNGAGGEEDSY 658
            :::         || .:|.|:|.|.|.:.:.:
  Rat   715 KSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEF 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	81/312 (26%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	81/312 (26%)
Mapk7	NP_001178476.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for cytoplasmic targeting. /evidence=ECO:0000250	2..77		8/21 (38%)
		STKc_ERK5	49..384	CDD:270842	90/349 (26%)
		Required for binding to MAP2K5. /evidence=ECO:0000250	78..139		20/61 (33%)
		Necessary for oligomerization. /evidence=ECO:0000250	140..406		69/306 (23%)
		TXY. /evidence=ECO:0000250	219..221		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..475		12/50 (24%)
		Nuclear localization signal. /evidence=ECO:0000250	505..539		4/33 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000