Protein Alignment KP78a and Prkaa1

DIOPT Version :10

• Sequence 1: NP_650066.1
• Gene: KP78a / 41362
• FlyBaseID: FBgn0026064
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: XP_036014946.1
• Gene: Prkaa1 / 105787
• MGIID: 2145955
• Length: 589
• Species: Mus musculus
• Alignment Length: 555
• Identity: 162/555 - (29%)
• Similarity: 245/555 - (44%)
• Gaps: 123/555 - (22%)

  Fly    96 GVYKIIKTLGKGNFAKVKLA----------------------IHVP--------TGREVAIKVID 130
            |.|.:..|||.|.|.|||:.                      :|:.        ||.:||:|:::
Mouse    25 GHYILGDTLGVGTFGKVKVPEKGYTDARLLGTLPQQQYLNSYVHIDCLVGKHELTGHKVAVKILN 89

  Fly   131 KTQLNT-SARQKLYREVKIMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRE 194
            :.::.: ....|:.||::.:||..||:|::|:|||.:...:::||||.|.|||||::.||||:.|
Mouse    90 RQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDE 154

  Fly   195 RDARVIFRQLVSAIQYCHSKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPP 259
            :::|.:|:|::|.:.|||...|||||||.||:|||.|||.||||||..|.......|.|.||||.
Mouse   155 KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN 219

  Fly   260 YAAPELFMGRKYAGPEVDAWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCEN 324
            |||||:..||.|||||||.||.||:||.|:.|:||||...:..|.:::..|.:..|.|::....:
Mouse   220 YAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVIS 284

  Fly   325 LMRKFLVLNPAKRTSLSAVMSDKWINLGHDESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVE 389
            |::..|.::|.||.::..:...:|..  .|....|  |.|.|.........:.|..:..|....|
Mouse   285 LLKHMLQVDPMKRAAIKDIREHEWFK--QDLPKYL--FPEDPSYSSTMIDDEALKEVCEKFECSE 345

  Fly   390 QSVKGQLF-----DDIYCTYML---------------LGVAKPRS---SNRSTK--PEAIPTVDL 429
            :.|...|:     |.:...|.|               |..:.|.|   .:..|:  ||.:|.:..
Mouse   346 EEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVA 410

  Fly   430 TTPAVSSPLPNI----------------------TTPTVTIAHVTLALD---------------- 456
            .||.....|..:                      :.|...:|.|..|:.
Mouse   411 ETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRV 475

  Fly   457 --KNPPIHSSSASG---------------RPIAPRLANAPNTPTSTPPTGPPAKPTRRTPARTPA 504
              |||...:.|...               |.|...:..| .:.|:||.........|      ..
Mouse   476 RRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEA-KSGTATPQRSGSISNYR------SC 533

  Fly   505 RKATNHTSGQGRPEPSSLPHTPQSKRASANMDVKP 539
            :::.:....||:|...||..:..|..:|. :||.|
Mouse   534 QRSDSDAEAQGKPSDVSLTSSVTSLDSSP-VDVAP 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	Protein Kinases, catalytic domain	98..349	CDD:473864	112/281 (40%)
		UBA_MARK_Par1	370..408	CDD:270522	8/57 (14%)
Prkaa1	XP_036014946.1	STKc_AMPK_alpha	24..309	CDD:270981	113/283 (40%)
		UBA_AID_AAPK1	326..390	CDD:270586	10/63 (16%)
		AMPKA1_C	434..587	CDD:213384	25/142 (18%)