DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KP78a and SIK1B

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001307572.1	Gene:	SIK1B / 102724428	-ID:	-	Length:	783	Species:	Homo sapiens

Alignment Length:	657	Identity:	231/657 - (35%)
Similarity:	337/657 - (51%)	Gaps:	102/657 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 SKFQSYVNGNGN--------GVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQ 140
            |:|.:...|.|.        |.|.|.:||||||||.||||.|..|..:||||:||||:|::|..:
Human     5 SEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLE 69

  Fly   141 KLYREVKIMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLV 205
            |:||||::|||||||:|::|:||:|::..||:|.|:|..||:||:|..||.:.|.:||..|.|::
Human    70 KIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQIL 134

  Fly   206 SAIQYCHSKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRK 270
            ||::|||...:||||||.||||||.:|:||:|||||||.:.....|.|:||||||||||:|.|::
Human   135 SAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKE 199

  Fly   271 YAGPEVDAWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPA 335
            |.||::|.||||||||.||.|||||||..|..||:|||.|::|:|:::|.|||:|:|:.||::||
Human   200 YEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPA 264

  Fly   336 KRTSLSAVMSDKWINL-------------GHDESDRLRPFREKPMELQDAARFDLLMSMGHKRRD 387
            :|.:::.:...:|:..             .|..:..|..:.|:.:        .::.::|..|:.
Human   265 RRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQAL--------GIMQTLGVDRQR 321

  Fly   388 VEQSVKGQLFDDIYCTYMLL---------------GVA---KPRSSNRSTKPEAIPTVDLTT--- 431
            ..:|::...::.....|.||               |.|   :||||:.|..  .:|...|:|
Human   322 TVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGL--EVPQEGLSTDPF 384

  Fly   432 -PAVSSPLPNITTPTVTIAHVTLALDKN---P---PIHSSSASG----RPIAPRLANAPNTPTST 485
             ||:..|.|.....:|..|.:...|..:   |   |: .:|.||    ||::|  ::..:|..|.
Human   385 RPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPV-DASCSGVFRPRPVSP--SSLLDTAISE 446

  Fly   486 PP-TGPPAKPTRRTPARTPARKATNHTSGQGRPEPSSL--------PHTPQSKRASANMDVKPTL 541
            .. .||..:..:.|....|:.....||..:.....|.|        |.|..|.....:.|...|
Human   447 EARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLT- 510

  Fly   542 LSAQRQLA------QTQKL--ANTPPRFQYPV----AQTP-NQAQGSSRRPTTL---YEKAEPAV 590
            .||.:..|      .||.|  |.:|.|...|.    :.|| .||||.......|   :::...|.
Human   511 FSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRAS 575

  Fly   591 TPLLVPKSPAMGARLLERIPGGGAVEKTSDKPFTRQ----NVARAT------FHFGQARSGKRGG 645
            ...|.....|...:|.:.....|.:.....|...||    ..:||:      ||......|..||
Human   576 DTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQVPASRASRGGLSPFHAPAQSPGLHGG 640

  Fly   646 GSGNGAG 652
            .:|:..|
Human   641 AAGSREG 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	142/250 (57%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	142/250 (57%)
SIK1B	NP_001307572.1	STKc_SIK	26..278	CDD:270973	142/251 (57%)
		UBA_SIK1	300..349	CDD:270591	8/56 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..377		8/25 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..477		6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810