DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KP78a and sik3

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_004916140.2	Gene:	sik3 / 100492939	XenbaseID:	XB-GENE-6042192	Length:	1284	Species:	Xenopus tropicalis

Alignment Length:	609	Identity:	224/609 - (36%)
Similarity:	316/609 - (51%)	Gaps:	126/609 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 GVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKLLNHPNIVRL 160
            |.|:|.:|:||||||.||||.|:.|..:||||:||||:|:....:|::|||:|||:|.||:|:||
Frog    24 GYYEIDRTIGKGNFAVVKLATHIVTRAKVAIKIIDKTKLDEENLKKIFREVQIMKMLCHPHIIRL 88

  Fly   161 FQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFVVHRDLKAEN 225
            :||:|:||.:|||.||||.||:|||||.:|||.|::||..|:|:|:|:.:||.:.:|||||||||
Frog    89 YQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARKKFKQIVAAVHFCHCRNIVHRDLKAEN 153

  Fly   226 LLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSLGVVLYTLVS 290
            ||||.::|||||||||.|.|.|...|:|:||||||||||||.|::|.||:||.||||||||.||.
Frog   154 LLLDANLNIKIADFGFSNRFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVC 218

  Fly   291 GSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSDKWINLGHDE 355
            |:|||||.||:.||.|||.||:|:|:::|.:||:|:|..|||.|:||.|:..:...||:..|..:
Frog   219 GALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLEPSKRLSMEQICKHKWMCQGEQD 283

  Fly   356 SDRLRPFRE----KPMELQDAARFDLLMS---MGHKRRDVEQSVKGQLFDDIYCTYMLL--GVAK 411
            .:..|...|    |....:|.....:|::   ||..|....||::...:|.....|.||  .:.:
Frog   284 LEFERLIAECQHVKLERQRDPLNEQVLLTMVEMGLDRERTLQSLRTDAYDHYSAIYSLLCDRLKR 348

  Fly   412 PRSSNRSTKPEAIPTVDLTTPAV----SSPLPNITTPTVTI---------AHVTLALDKN----- 458
            .::....|:|.|..||..:||:|    :|...:|..|.|.:         .:.|:.||.:
Frog   349 HKTLRLPTQPSAPRTVSYSTPSVQADAASNTVSINVPQVQLINPENQIVETNGTMTLDSDEAEEP 413

  Fly   459 ------------------PPIHSSSASGR-----PIAPRL------------ANAPNTPTSTPPT 488
                              |..|:.|.:..     |..||:            .|..:|....||:
Frog   414 SPEALARYLSMRRHTVGVPDTHNESGTDELQKIFPGFPRVTQQIPFLPVTQNTNVLHTLLPMPPS 478

  Fly   489 G-----------PPA------------------------------KPTRRTPARTPARKAT---- 508
            .           ||.                              :|...:|..|.|...|
Frog   479 AHLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQMHAQLLLKRPRGPSPLVTMATTVTAVTP 543

  Fly   509 -NHTSGQGRPEPSSLPH--TPQSKR-----ASANMDVKPTLLSAQRQLAQTQKLANT--PPRFQY 563
             :..|..|.|:..::..  ..::||     .|...::.|.|   ||||.|.|...|.  ||..
Frog   544 VDEESSDGEPDQEAVQRYLANRTKRHTLAMTSPTAEIPPEL---QRQLGQQQAFRNRAWPPHL-- 603

  Fly   564 PVAQTPNQAQGSSRRPTTLYEKAE 587
                .|:..:...:...||:..||
Frog   604 ----APDLHRSMYKDSNTLHLPAE 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	153/250 (61%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	153/250 (61%)
sik3	XP_004916140.2	STKc_SIK	25..277	CDD:270973	153/251 (61%)
sik3	XP_004916140.2	UBA_SIK3	306..350	CDD:270593	10/43 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910