Protein Alignment KP78a and mark4

DIOPT Version :10

• Sequence 1: NP_650066.1
• Gene: KP78a / 41362
• FlyBaseID: FBgn0026064
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: XP_012824414.1
• Gene: mark4 / 100491038
• XenbaseID: XB-GENE-6042140
• Length: 681
• Species: Xenopus tropicalis
• Alignment Length: 704
• Identity: 283/704 - (40%)
• Similarity: 395/704 - (56%)
• Gaps: 132/704 - (18%)

  Fly    23 MTAANKE-NDPDSHFTGTIVTTGATAQPATPTTSNATALPATPTVAAGQDLGDGACSSKNTDSKF 86
            :||.|:. ||..........:|..:..|..|...:.:::|..|.|
 Frog     4 VTAGNERINDTSGSTRSEKASTPLSWPPRPPGARSRSSVPEEPHV-------------------- 48

  Fly    87 QSYVNGNGNGVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKL 151
                     |.|::::|:|||||||||||.||.||||||||:|||||||.|:.|||:|||:|||.
 Frog    49 ---------GNYRLLRTIGKGNFAKVKLARHVLTGREVAIKIIDKTQLNPSSLQKLFREVRIMKG 104

  Fly   152 LNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFV 216
            |||||||:||:|||:|:||||:|||||.||:||:||.:|||:|::||..|||:|||:.|||.|.:
 Frog   105 LNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNI 169

  Fly   217 VHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSL 281
            |||||||||||||...|||||||||.|.|.|..:|:||||||||||||||.|::|.|||||.|||
 Frog   170 VHRDLKAENLLLDSESNIKIADFGFSNEFTPGGKLDTFCGSPPYAAPELFQGKRYNGPEVDVWSL 234

  Fly   282 GVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSD 346
            ||:|||||||||||||..||||||||||||||:|:|:|.|||.::|:||||||:||.:|..:|:|
 Frog   235 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEGVLRRFLVLNPSKRCTLDQIMND 299

  Fly   347 KWINLGHDESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLLGVAK 411
            ||:|:|.| ||.|:|::|...:..|..|.::::.||:.|.:::.::....::::..||:||| .|
 Frog   300 KWMNIGFD-SDDLKPYKEPEEDNADPKRIEIMLEMGYSREEIKDALSSNKYNEVMATYLLLG-RK 362

  Fly   412 PRSSNRSTKPEAIPTVDLTTPAVSSPLPNITTPTVTIAHVTLALDKNPPIHSSSASGRPIAPRLA 476
            |.|....::.::  |:.|:...|:|.:.|..|             |:..:||.:..|.....|.:
 Frog   363 PESEGGESRSDS--TLSLSRSRVASDVTNGAT-------------KSSSVHSKNQRGYQRQRRHS 412

  Fly   477 NAPNTPTSTPPTGPPAKPT--RRTP----------ARTPARKATNHTSGQGRPEPSSLP-----H 524
            :.         .||...|:  :|:|          .|...|:.:....|..||.|.|.|     |
 Frog   413 DF---------CGPAPAPSQAKRSPPGVGDDGAVGERLAPRRGSGSVGGGSRPPPPSSPMVSHAH 468

  Fly   525 TP-QSKRASANMDVKPTLLSAQRQLAQTQKLANTPP-----RFQYPVAQTPNQAQGSSRRPTTLY 583
            .| :::......:..||.:             ||||     |..|....     :.||.|.:.|:
 Frog   469 NPNKAEIPEPRKEAPPTTI-------------NTPPGVMGRRNTYVCTD-----RHSSERHSLLH 515

  Fly   584 EKAEPAVTPLLVPKSPAMGARLLERIPGGGAVEKTSDKPFTRQNVARATFHFGQARSGKRGGGSG 648
            ...|.:.||   .:.||:.       |...::.:.|.  .:|.:..|:|||.|..|. :||
 Frog   516 NDKENSSTP---SRPPALS-------PSTQSIAERSS--LSRGSNVRSTFHGGHVRD-RRG---- 563

  Fly   649 NGAGGEEDSYQTPPLSA--------DDTKPASRVGFFSKLTARFGRRVIHLNEK 694
                      |.||.|:        :.::..:....|||||::..|||...:|:
 Frog   564 ----------QNPPPSSPTHPHEGLNQSRTRATSNLFSKLTSKLTRRVTDESER 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	Protein Kinases, catalytic domain	98..349	CDD:473864	182/250 (73%)
		UBA_MARK_Par1	370..408	CDD:270522	8/37 (22%)
mark4	XP_012824414.1	STKc_MARK	50..302	CDD:270974	182/251 (73%)
		UBA_MARK_Par1	323..361	CDD:270522	10/38 (26%)