DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78a and mark3

DIOPT Version :9

Sequence 1:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_031747282.1	Gene:	mark3 / 100329119	XenbaseID:	XB-GENE-867495	Length:	794	Species:	Xenopus tropicalis

Alignment Length:	757	Identity:	304/757 - (40%)
Similarity:	413/757 - (54%)	Gaps:	157/757 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SEKTAMTAANKENDPDSHFTGTIVTTGATAQPATPTTSNATALPATPTVAAGQDLGDGACSSKNT 82
            |.:|.:...| |.|.::|      |:....:....:.|......:..::|        :|:.:
Frog     2 STRTPLPTVN-ERDTENH------TSHGDGRQDVLSRSGRQGARSRNSIA--------SCADE-- 49

  Fly    83 DSKFQSYVNGNGNGVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVK 147
                |.::     |.|:::||:|||||||||||.|:.||||||||:|||||||.::.|||:|||:
Frog    50 ----QPHI-----GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVR 105

  Fly   148 IMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCH 212
            |||:|||||||:||:|||:|:||||||||||.||:||:||.:|||:|::||..|||:|||:||||
Frog   106 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 170

  Fly   213 SKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVD 277
            .|.:|||||||||||||..||||||||||.|.|....:|:||||||||||||||.|:||.|||||
Frog   171 QKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD 235

  Fly   278 AWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSA 342
            .|||||:|||||||||||||..||||||||||||||:|:|:|.|||||:::||||||:||.:|..
Frog   236 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPSKRGTLEQ 300

  Fly   343 VMSDKWINLGHDESDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLL 407
            :|.|:|||.||:| |.|:||.|..:::.|..|.|:::.||:.|.::::|:....:|:|..||:||
Frog   301 IMKDRWINAGHEE-DELKPFVEPELDISDQKRIDIMVGMGYSREEIQESLSKMKYDEITATYLLL 364

  Fly   408 G-------VAKPRSSNRSTKPEAIPTVDLTTPAVSSP-----------------------LPNIT 442
            |       .:...||:..:..:..|..||...:..||                       :|::|
Frog   365 GRKSSELDASDSSSSSNLSLAKVRPNSDLNNSSGQSPHHKGRSISSSQKQRRYSDHAGPAVPSVT 429

  Fly   443 TPTVTIAHVTLALDKNPPI---HSSSASGR---PIAPRLANAPNTPTSTPPTGPPAKPTRRTPAR 501
            .........|...|....:   ..||::||   |.:|.|.||.|          |.|      |.
Frog   430 AYPKRSQTSTTDNDLKDEVGQSRKSSSTGRGVTPPSPMLGNASN----------PNK------AD 478

  Fly   502 TPARKATNHTSGQGRPEPSSLPHTPQSKRASANMDVKPTLLSAQRQLAQTQKLANTPPRFQYPVA 566
            .|.||            .||:  .|.|...|:.|..:.|.:.::|           .|..::.|.
Frog   479 IPERK------------KSSV--VPTSNSTSSGMTRRNTYVCSER-----------APTDRHSVI 518

  Fly   567 QTPNQAQGSSRRPTTLYEKA-EPA--------VTPLLVPKSPAMGA-RLLERIP---------GG 612
            |     .|.....|.::..| .||        ...|..|||.:|.| |..|.:|         |.
Frog   519 Q-----NGKENSLTGIFTYATSPASVCAISSIFARLRHPKSMSMSASRHSEMLPPIASEGDNFGP 578

  Fly   613 GAV--EKTS-------------DK-PFTRQNVARATFHFGQARSGKRGGGSGNGAGGEED-SYQT 660
            ..:  ::||             |: .|.|...:|:||| ||.|  :|...:.||...... |::.
Frog   579 ATIPDQRTSVASTHSITSTTTPDRMRFPRGTASRSTFH-GQLR--ERRTATYNGPPASPSLSHEA 640

  Fly   661 PPLSADDTKPASRVGFFSKLTARFGRRVIHLNEKDVTEQRKN 702
            .|||  .|:.......|||||::..||:       .||..:|
Frog   641 TPLS--QTRSRGSTNLFSKLTSKLTRRL-------PTESERN 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	184/250 (74%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	184/250 (74%)
mark3	XP_031747282.1	STKc_MARK	55..307	CDD:270974	184/251 (73%)
		UBA_MARK3_4	325..367	CDD:270590	14/41 (34%)
		MARK1-3_C	695..792	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48420
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000