Protein Alignment KP78a and brsk2b

DIOPT Version :10

• Sequence 1: NP_650066.1
• Gene: KP78a / 41362
• FlyBaseID: FBgn0026064
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: XP_009301700.1
• Gene: brsk2b / 100149571
• ZFINID: ZDB-GENE-100422-3
• Length: 886
• Species: Danio rerio
• Alignment Length: 629
• Identity: 201/629 - (31%)
• Similarity: 298/629 - (47%)
• Gaps: 132/629 - (20%)

  Fly    78 SSKNTDSKFQSYVNGNGNGVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKL 142
            ||...|:..|.:  .|..|.|::.||||||....|||.||..|.::||||::::.:|:.|...|:
Zfish     2 SSSGKDNSSQQH--ANYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKV 64

  Fly   143 YREVKIMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSA 207
            .||:.|:||:.||::::|..|.|:::.||||:|:.|.|||||:|||.||:..::||..|||::||
Zfish    65 EREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISA 129

  Fly   208 IQYCHSKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYA 272
            :.:|||..:.|||||.||||||:..||:|||||..:....::.|||.||||.||.||:..|.||.
Zfish   130 LDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYD 194

  Fly   273 GPEVDAWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKR 337
            |.:.|.||.||:|:.|:.|:||||...|:.|.|:|..|.:.:|::|..||:||:|..:.::..||
Zfish   195 GRKADVWSCGVILFALLVGALPFDDDNLRNLLEKVKLGVFHMPHFIPPDCQNLLRGMIEVDATKR 259

  Fly   338 TSLSAVMSDKWINLGHDESDRLRPFREKPMELQDAARF---------DLLMSMGHKR---RDVEQ 390
            .:|..:....|...|.:|     |..|:|:..:.|.|.         |:|.|| |..   ||..:
Zfish   260 LTLEQIQKHTWYIGGKNE-----PEPEQPVPRKVAIRTLPSTEDIDPDVLESM-HSLGCFRDKNK 318

  Fly   391 SVKGQLFDD------IYCTYMLLG------------------VAKPR--------SSNRSTKPEA 423
            .:|..|.||      ||  ::||.                  :..||        :.:...:||.
Zfish   319 LMKDLLSDDDNQEKMIY--FLLLDRKERYPSHEDQNLPPRNEIDPPRKRVDSPLLTRHNKRRPER 381

  Fly   424 IPTVDLTTPAVSSPLP--------------NITTPTVTIAHVTLALDKNPPIHSSSASGRPIAPR 474
            .....|:.....||:|              ::.:.::.|:      |.||.:.|.....|.|:..
Zfish   382 KSMEVLSVTEGGSPVPVRRAIDMAQHGQSKSVFSKSLDIS------DANPILQSKEERSRSISGA 440

  Fly   475 LANAPNTPTSTPPTGPPAKPTRR------------TPARTPARKATNHTSGQGRPEPSSLPHTP- 526
            .:....:|.|:|      :|.||            :|..:|........:|.|       ||:|
Zfish   441 SSGLSTSPLSSP------RPMRRFAVPPQSSDLTYSPNHSPTHAPVARLNGTG-------PHSPK 492

  Fly   527 ---------QSKRASANMDVKPTLLSAQRQLAQTQKLANTPPRFQYPVAQT---------PNQAQ 573
                     |....:..:..||.:.....|..::..|.|:.|  ..|||::         |.|..
Zfish   493 IFLPKTAADQLNNKTQTLPAKPKVADKPLQATRSNPLPNSTP--VPPVAKSEPSTPCQPLPPQIP 555

  Fly   574 GSS--RRPTTLYEKAEPAVTP--LLVPKSPAMGARLLERIPGGG 613
            ||.  |||        |...|  |.||.||....||....|..|
Zfish   556 GSPKIRRP--------PLTVPPKLSVPLSPLSPIRLHHLHPLAG 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78a	NP_650066.1	Protein Kinases, catalytic domain	98..349	CDD:473864	116/250 (46%)
		UBA_MARK_Par1	370..408	CDD:270522	16/55 (29%)
brsk2b	XP_009301700.1	STKc_BRSK1_2	18..271	CDD:270983	117/252 (46%)
		UBA_BRSK	298..351	CDD:270525	15/55 (27%)
		PHA03247	<342..630	CDD:223021	56/279 (20%)