DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KP78b and FRK1

DIOPT Version :9

Sequence 1:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_015184.1	Gene:	FRK1 / 855962	SGDID:	S000006062	Length:	865	Species:	Saccharomyces cerevisiae

Alignment Length:	578	Identity:	162/578 - (28%)
Similarity:	261/578 - (45%)	Gaps:	125/578 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 YGVYKIIKTLGKGNFAKVKL------------AIHLPTGREVAIKLIDKTALNTIARQ--KLYRE 110
            :|.|.:..|||:|.|.||||            ....|  ::||||||.:.:::...|:  |:|||
Yeast    38 FGPYILGSTLGEGEFGKVKLGWPKNFSNSSNSTFDFP--KQVAIKLIKRDSISNDYRKEVKIYRE 100

  Fly   111 VNIMKKLNHPNIVRLLQVIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEY 175
            :|.:|.|:|||||:|.:|:::.|.:.:|:||..|||.:.|:.|..|::|.:|..||.||:|.:.|
Yeast   101 INALKHLSHPNIVKLEEVLQNSRYIGIVLEYACGGEFYKYIQKKRRLKEMNACRLFSQLISGVHY 165

  Fly   176 CHSKSIVHRDLKAENLLLDQQMKLKIADFGFSTTFEPKAPL-ETFCGSPPYAAPEL-FRGKKYSG 238
            .|||.:||||||.||||||:...|.|.||||...|..:..| :|.||||.|||||| ...:.|..
Yeast   166 IHSKGLVHRDLKLENLLLDKNENLVITDFGFVNEFCSRNELMKTSCGSPCYAAPELVISAEPYEA 230

  Fly   239 PEVDSWSLGVVLYTLVSGSLPFD-------GTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLV 296
            .:.|.||.||:||.:::|.||:|       |:::..|.:.:.....:.|.|:......|:|:.||
Yeast   231 RKADIWSCGVILYAILAGYLPWDDDPNNPEGSDIGRLYNYINSTPLKFPDYILPIPRDLLRRMLV 295

  Fly   297 LNPTQRTSLSAVMADRWINMGYEQGNGLRPFQEKPMDLHDVNRLSLLSNMGHKPRDVEQSLKNQK 361
            .:|.:|.:|..:....|:                                  ||.....|:...:
Yeast   296 SDPKKRINLKQIKKHEWL----------------------------------KPHSSFLSITPDE 326

  Fly   362 FDDIYCTYMLLDVAKPR-------STACSEKS-GSSFRETPTAMPGSSRIPVPIAAP-----NVT 413
            :|.:..|..:..:||||       .::||..| ||...:..:.:..|:.|..| |.|     ::.
Yeast   327 WDKLNNTQSVFRLAKPRRRYGSRPQSSCSTSSLGSRSDKRDSLVIDSTLITFP-APPQESQNHII 390

  Fly   414 ISQVTFALDK--------STPNRP-AATSIRPMAPRLANA-----------LTPL---------- 448
            ....:.|.|:        :..||. :|.|:...|  :.||           |:|:
Yeast   391 TRPASIASDQRLSPIRRSNRHNRSNSAASVALQA--VVNADREYVLSHEQSLSPVQNIRQTTGNM 453

  Fly   449 --PLTPPPKKYICCSASKAANPRR--SEPSSIPQSAMPKKGVGSPVDVKTTLLSAQRKLAVNQKL 509
              .|:|||          |.:|..  .|.:.|.::.:....:...::.:::......|:..|...
Yeast   454 TASLSPPP----------AISPGDIIIETTPIKRNTISGSSIVPSLEEESSTTMQTSKIQPNNMA 508

  Fly   510 TSASHQIRSPITQSPSQASECTRTPPTHFEMLDSTSTPLKVLKLVASNSQTPPSTENT 567
            :|.:||.....||:..|:::      ..:....|:.|..:.......:..|||...||
Yeast   509 SSQNHQYNKNKTQNSLQSAK------NFYRTSSSSHTKPRPTSYHPGSYTTPPYNSNT 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	107/273 (39%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	107/273 (39%)
FRK1	NP_015184.1	PKc_like	39..313	CDD:419665	108/275 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910