Protein Alignment KP78b and NUAK2

DIOPT Version :9

• Sequence 1: NP_001163587.1
• Gene: KP78b / 41361
• FlyBaseID: FBgn0026063
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_112214.3
• Gene: NUAK2 / 81788
• HGNCID: 29558
• Length: 628
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 180/554 - (32%)
• Similarity: 246/554 - (44%)
• Gaps: 145/554 - (26%)

  Fly    63 YKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLY---REVNIMKKLNHPNIVR 124
            |:.::|||||.:.|||.| ...:||.||||.|.|..:..  .|.|.   ||:.||..||||:|:.
Human    53 YEFLETLGKGTYGKVKKA-RESSGRLVAIKSIRKDKIKD--EQDLMHIRREIEIMSSLNHPHIIA 114

  Fly   125 LLQVIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAE 189
            :.:|.|:...:.:||||.|.|:|::|:.:..::.||:||..|||:|||:.|||...:||||||.|
Human   115 IHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLE 179

  Fly   190 NLLLDQQMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLV 254
            |:|||....:||||||.|..:.....|:||||||.||:||:..||.|:|||||||||||:||.||
Human   180 NILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYILV 244

  Fly   255 SGSLPFDGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYE 319
            .|::||||.:.|.|..::..|.||.|...|..| .|||..|::|||:|.:|..|.:..|:|.||.
Human   245 HGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTRRATLEDVASHWWVNWGYA 308

  Fly   320 QGNGLRPFQEKPMD------------LHDVNRLS---LLSN------------------------ 345
            ...|   .||.|.:            :.|..|.|   ||.|
Human   309 TRVG---EQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPGGGSTTPGLER 370

  Fly   346 -----MGHKPRDVEQSLKNQKFDDIYCTYMLLDVAKPRSTACSEKSGSSFRETPTA-MPGSSRIP 404
                 ...|..|:.|||.:...||                              || .||.|.:.
Human   371 QHSLKKSRKENDMAQSLHSDTADD------------------------------TAHRPGKSNLK 405

  Fly   405 VPIAAPNVTISQVTFALDKSTPNRPAATSIRPMAPRLANALTPLPLTPP------PKKYICCSAS 463
            :|.......:|.....:.:..|.                 |:|:|.:|.      |||.|.
Human   406 LPKGILKKKVSASAEGVQEDPPE-----------------LSPIPASPGQAAPLLPKKGIL---- 449

  Fly   464 KAANPRRS------EPSSIPQ---------SAMPKKGVGSPVDVKTTLLSAQRKLAVNQKLTSAS 513
            |....|.|      |||...:         |..||:  ..|......||..:..|.:|.|.:..:
Human   450 KKPRQRESGYYSSPEPSESGELLDAGDVFVSGDPKE--QKPPQASGLLLHRKGILKLNGKFSQTA 512

  Fly   514 HQIRSPITQSPSQASECTRTPPTHFEMLDSTSTP 547
            .::.:|.|                |..||..:.|
Human   513 LELAAPTT----------------FGSLDELAPP 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	122/253 (48%)
		S_TKc	63..314	CDD:214567	122/253 (48%)
NUAK2	NP_112214.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..493		33/190 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..562		180/554 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2321
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860