DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KP78b and mark3b

DIOPT Version :9

Sequence 1:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_009293196.1	Gene:	mark3b / 767634	ZFINID:	ZDB-GENE-060929-80	Length:	834	Species:	Danio rerio

Alignment Length:	570	Identity:	258/570 - (45%)
Similarity:	341/570 - (59%)	Gaps:	66/570 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GSSGGRSSPKFQSYVNGNGY-GVYKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIAR 104
            |.||.|......|..:...: |.|:::||:|||||||||||.|:.||||||||:||||.||..:.
Zfish    53 GRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL 117

  Fly   105 QKLYREVNIMKKLNHPNIVRLLQVIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQL 169
            |||:|||.|||.|||||||:|.:|||:::||||||||.||||:|:|||.:|||:|::||..|||:
Zfish   118 QKLFREVRIMKILNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 182

  Fly   170 VSAIEYCHSKSIVHRDLKAENLLLDQQMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGK 234
            |||::|||.|.||||||||||||||..|.:||||||||..|.....|:||||||||||||||:||
Zfish   183 VSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTIGNKLDTFCGSPPYAAPELFQGK 247

  Fly   235 KYSGPEVDSWSLGVVLYTLVSGSLPFDGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNP 299
            ||.|||||.|||||:|||||||||||||.||||||:||||||||:|:|:|.:||:|:::||||||
Zfish   248 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 312

  Fly   300 TQRTSLSAVMADRWINMGYEQGNGLRPFQEKPMDLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDD 364
            .:|.:|..:|.|||||.|.|: ..|:||.|..:|:.|..|:.::..||:...::.:||...|:|:
Zfish   313 VKRGTLEQIMKDRWINAGCEE-EELKPFVEPELDISDQKRIDIMVGMGYSREEIHESLTRMKYDE 376

  Fly   365 IYCTYMLLDVAKPRSTACSEKSGSSFRETPTAMPGS--------SRIPVPIAA------------ 409
            |..||:||. .|......|:.|.||......|.|.|        |.:.|...|
Zfish   377 ITATYLLLG-RKSTELEVSDSSSSSNLSLAKARPNSEHNNGQSPSHLKVQKNASTNQKQRRYSDQ 440

  Fly   410 -----PNVTI---SQVTFALDK-----STPNRPAATS----IRPMAPRLANALTPLPLTPPPKKY 457
                 |:|..   ||.|.|..:     |...|.:::|    :.|.:|.|.||..|
Zfish   441 AGPTIPSVGYPKRSQTTSAESEHKEEGSAQARKSSSSGSRGMAPASPMLGNANNP---------- 495

  Fly   458 ICCSASKAANPRRSEPSSIPQSAMPKKGVGSPVDVKTTLLSAQRKLAVNQKLTSASHQIRSPITQ 522
                 :||..|.|.:.:..|.:    ..|.|.:..:.|.:.::|      ..|.....|::....
Zfish   496 -----NKADIPDRKKSAGAPGN----NSVSSGMTRRNTYVCSER------NATDRHSVIQNGKEN 545

  Fly   523 SPSQASECTRTPPTHFEM-LDSTSTPLKVLKLVASNSQTPPSTENTNRPT 571
            |.|:.|.|..|.||.:.: |.|:|..:::....|::......|.....||
Zfish   546 SLSEMSGCVSTSPTAYAVALASSSASVRLRHQKAASLSASGHTCRATLPT 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	178/250 (71%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	178/250 (71%)
mark3b	XP_009293196.1	STKc_MARK	75..327	CDD:270974	178/251 (71%)
		S_TKc	76..327	CDD:214567	178/250 (71%)
		UBA_MARK3_4	345..387	CDD:270590	14/42 (33%)
		MARK1-3_C	735..832	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810