Protein Alignment KP78b and Mark4

DIOPT Version :10

• Sequence 1: NP_650065.1
• Gene: KP78b / 41361
• FlyBaseID: FBgn0026063
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_001178000.1
• Gene: Mark4 / 680407
• RGDID: 1591792
• Length: 752
• Species: Rattus norvegicus
• Alignment Length: 629
• Identity: 266/629 - (42%)
• Similarity: 361/629 - (57%)
• Gaps: 116/629 - (18%)

  Fly    16 PGPNTSISTTATPPSAAAQNVGGCFGSS--GGR------SSPKFQSYVNGNGYGVYKIIKTLGKG 72
            ||.:.:..|..|..|..:.:.|..:.|.  |.|      |.|:.|.:|     |.|::::|:|||
  Rat     9 PGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHV-----GNYRLLRTIGKG 68

  Fly    73 NFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRLLQVIESERTLYL 137
            ||||||||.|:.||||||||:||||.||..:.|||:|||.|||.|||||||:|.:|||:|:||||
  Rat    69 NFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYL 133

  Fly   138 VMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAENLLLDQQMKLKIA 202
            ||||.|.||:|:|||.:|||:|::||..|||:|||:.|||.|:||||||||||||||.:..:|||
  Rat   134 VMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIA 198

  Fly   203 DFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLPFDGTNLKE 267
            |||||..|...:.|:||||||||||||||:||||.|||||.|||||:|||||||||||||.||||
  Rat   199 DFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKE 263

  Fly   268 LRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYEQGNGLRPFQEKPM 332
            ||:||||||||||:|:|.:|||::|:||||||.:|.:|..:|.|:|||:||| |..|:|:.|...
  Rat   264 LRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYE-GEELKPYTEPEE 327

  Fly   333 DLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDDIYCTYMLLDVAKPRSTACSEKSGSSFRETPTAM 397
            |..|..|:.::..||:...:::::|.|||::::..||:||.    |.|   |:.|.      ...
  Rat   328 DFGDTKRIEVMVGMGYTREEIKEALTNQKYNEVTATYLLLG----RKT---EEGGD------RGA 379

  Fly   398 PG--SSRIPVPIAAPNVTISQVTFALDK------STPNR---------PAATSIRPMAPRLANAL 445
            ||  .:|:..|....|.|.|....:.:|      ||.:|         |:...:.|.....:...
  Rat   380 PGLALARVRAPSDTTNGTSSSKGSSHNKGQRTSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGD 444

  Fly   446 TPLPLTPPPKKYICCSA---------------SKAANPRRSE-----------PSSIPQSAMPKK 484
            |.|.....|.:...|||               |.|.||.::|           |:::|.|.|.:
  Rat   445 TELKEERLPGRKASCSAAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTR- 508

  Fly   485 GVGSPVDVKTTLLSAQRKLAVNQKLTSASHQIRSPITQSPSQASECTRTPPTHFEMLDSTSTPLK 549
                    :.|.:..:|..:..|.|          :......:|..:|.||         ::|
  Rat   509 --------RNTYVCTERPGSERQSL----------LPNGKENSSGTSRVPP---------ASP-- 544

  Fly   550 VLKLVASNSQTPPSTENTNRPTRVGFFSKLS-ARFVRRSLHKGE 592
                 :|:|..|||.|.          |:|: ...:|.:.|.|:
  Rat   545 -----SSHSLAPPSGER----------SRLARGSTIRSTFHGGQ 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_650065.1	Protein Kinases, catalytic domain	63..314	CDD:473864	177/250 (71%)
		UBA_MARK_Par1	335..373	CDD:270522	11/37 (30%)
Mark4	NP_001178000.1	STKc_MARK	58..310	CDD:270974	177/251 (71%)
		UBA_MARK3_4	328..370	CDD:270590	13/45 (29%)
		MARK4_C	654..752	CDD:213382