Protein Alignment KP78b and Smok3b

DIOPT Version :10

• Sequence 1: NP_650065.1
• Gene: KP78b / 41361
• FlyBaseID: FBgn0026063
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_001034978.1
• Gene: Smok3b / 622474
• MGIID: 3615348
• Length: 504
• Species: Mus musculus
• Alignment Length: 565
• Identity: 167/565 - (29%)
• Similarity: 260/565 - (46%)
• Gaps: 120/565 - (21%)

  Fly    63 YKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQ----KLYREVNIMKKLNHPNIV 123
            |.:::|:|.|..|.||||.|..||..||:|.|.|       |:    ::..||.::...:||||:
Mouse    28 YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIRK-------REYWCNRVISEVELLMMADHPNII 85

  Fly   124 RLLQVIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKA 188
            .||||||:::.:||:||...|..|:.::.|.|.::|.:||.||:||:||:.|||::.|||||||.
Mouse    86 SLLQVIETKKKVYLIMELCKGKSLYQHIRKAGYLQEHEARALFKQLLSAMNYCHNQGIVHRDLKP 150

  Fly   189 ENLLLDQQMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTL 253
            :|:::::..|:||.|||..|..:|...|..|||:.|::|||:.....|.||::|.|:||||||.:
Mouse   151 DNIMVEKDGKVKIIDFGLGTKVKPGQKLNLFCGTYPFSAPEVLLSTPYDGPKIDVWTLGVVLYFM 215

  Fly   254 VSGSLPFDGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGY 318
            |:|.:|||..::|:|..|:|.|||.:|..:|.|.:.|:...:..||..|.:::.||...|:.
Mouse   216 VTGKIPFDACSIKKLVKRILAGKYSIPSRLSAELQDLLSLLMTANPKLRPTVAEVMVHPWVT--- 277

  Fly   319 EQGNGL--RPFQEKPMDLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDDIYCTYMLLDVAKPRSTA 381
             :|:|:  .|.:|:.....|...:..:.::|.:.:|:|.||:.:||:....:|.||.
Mouse   278 -EGSGVFPDPCEEQTPLKPDPAIVKAMGHIGFQAQDIEDSLRQRKFNQTMASYCLLK-------- 333

  Fly   382 CSEKSGSSFRETPTAMPGSSRIPVPIAAPNVTISQVTFALDKSTPNRPAATSIRPMAPRLANALT 446
                                             .|:....|:.|..||...|:.|....:..|.|
Mouse   334 ---------------------------------KQILKECDRPTRARPVNPSVTPFPSLVDTATT 365

  Fly   447 PLPLTPPPKKYICCSASKAANPRRSEPSSIPQSAMPKKGVGSPVDVKTTLLSAQRKLAVNQKLTS 511
            .|.|.                 ||....:.|.|                  ||.|:::|..|.||
Mouse   366 RLGLR-----------------RRENEPTCPWS------------------SANRQVSVCGKSTS 395

  Fly   512 ASHQIRSPITQSPSQASECTRTPPTHFEMLDSTSTPLKVLKLVAS---NSQTPPSTENTNRPTRV 573
            .....|   ...||.......|.||    :|.|.|..:.:..:.|   ..|...|.|:|...||.
Mouse   396 KKRDRR---VSWPSVLGRPRHTAPT----MDHTRTRTRSVPCICSMFCTVQPNSSEESTQGHTRA 453

  Fly   574 GFFSKLS------------ARFVRRSLHK-----GEKDISEQGRN 601
            ....|..            .|.:..::.|     ..|:.|..|:|
Mouse   454 SAADKPVHSRGWPRGIKGWTRMIGNAMRKLCCCIPSKETSHLGQN 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KP78b	NP_650065.1	Protein Kinases, catalytic domain	63..314	CDD:473864	106/254 (42%)
		UBA_MARK_Par1	335..373	CDD:270522	10/37 (27%)
Smok3b	NP_001034978.1	STKc_AMPK-like	27..275	CDD:270905	106/253 (42%)
		UBA_MARK_Par1	295..334	CDD:270522	11/79 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..421		11/38 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..468		6/26 (23%)